The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals
ITK and Rlk/Txk are the predominant Tec family of tyrosine kinases expressed in T cells, and are involved in T cell antigen receptor mediated activation of T cells. These kinases require prior activation of Lck, Zap-70 and PI3-kinase for efficient activation. They share major substrates with both Lc...
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| Veröffentlicht in: | The international journal of biochemistry & cell biology 2002-10, Vol.34 (10), p.1184-1189 |
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| container_title | The international journal of biochemistry & cell biology |
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| creator | August, Avery Fischer, Angela Hao, Shengli Mueller, Cynthia Ragin, Melanie |
| description | ITK and Rlk/Txk are the predominant Tec family of tyrosine kinases expressed in T cells, and are involved in T cell antigen receptor mediated activation of T cells. These kinases require prior activation of Lck, Zap-70 and PI3-kinase for efficient activation. They share major substrates with both Lck and Zap-70, however the pathways they regulate are unclear. Recent evidence suggests that these kinases may not activate unique pathways, but instead serve as amplifiers for the upstream kinases Lck and Zap-70. This review will discuss the evidence for this view. |
| doi_str_mv | 10.1016/S1357-2725(02)00068-7 |
| format | Article |
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This review will discuss the evidence for this view.</description><subject>B cell activation</subject><subject>BTK</subject><subject>Enzyme Activation</subject><subject>Humans</subject><subject>ITK</subject><subject>Protein Conformation</subject><subject>Protein-Tyrosine Kinases - chemistry</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>Receptors, Antigen, T-Cell - metabolism</subject><subject>Rlk</subject><subject>Signal Transduction</subject><subject>T cell activation</subject><subject>T-Lymphocytes - enzymology</subject><subject>Txk</subject><issn>1357-2725</issn><issn>1878-5875</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMojo4-gpKVKFjNpWnSlcjgDQZcWNehTU812ptJR5i3N52OuHSTE8J3cs7_IXRCyRUlNLl-oVzIiEkmzgm7IIQkKpI76IAqqSKhpNgN919khg69_wgQFYzvoxlllEmRpAcoy94BZ2BwlTe2XuOuwsPadd62gD9tm3vw2LY4wwbq2l_ivOlrW1lwfkSnZ-zAQD90Dnv71ua1P0J7VShwvK1z9Hp_ly0eo-Xzw9PidhkZntAhAi6lAcpYLqkyJCUljwVJhYoFFKwMR1IoWRSFAp7wWPIqDolSYDwmCkKSOTqb_u1d97UCP-jG-nGjvIVu5bWkaUyYEgEUE2hCNO-g0r2zTe7WmhI96tQbnXp0pQnTG51ahr7T7YBV0UD517X1F4CbCYAQ8zto0d5YaA2UNkgZdNnZf0b8ANvEgvE</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>August, Avery</creator><creator>Fischer, Angela</creator><creator>Hao, Shengli</creator><creator>Mueller, Cynthia</creator><creator>Ragin, Melanie</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals</title><author>August, Avery ; Fischer, Angela ; Hao, Shengli ; Mueller, Cynthia ; Ragin, Melanie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-e377ce122a718c090d345095845eb2d5eb6b87bbb8e363473f41359e23408e523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>B cell activation</topic><topic>BTK</topic><topic>Enzyme Activation</topic><topic>Humans</topic><topic>ITK</topic><topic>Protein Conformation</topic><topic>Protein-Tyrosine Kinases - chemistry</topic><topic>Protein-Tyrosine Kinases - metabolism</topic><topic>Receptors, Antigen, T-Cell - metabolism</topic><topic>Rlk</topic><topic>Signal Transduction</topic><topic>T cell activation</topic><topic>T-Lymphocytes - enzymology</topic><topic>Txk</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>August, Avery</creatorcontrib><creatorcontrib>Fischer, Angela</creatorcontrib><creatorcontrib>Hao, Shengli</creatorcontrib><creatorcontrib>Mueller, Cynthia</creatorcontrib><creatorcontrib>Ragin, Melanie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The international journal of biochemistry & cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>August, Avery</au><au>Fischer, Angela</au><au>Hao, Shengli</au><au>Mueller, Cynthia</au><au>Ragin, Melanie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals</atitle><jtitle>The international journal of biochemistry & cell biology</jtitle><addtitle>Int J Biochem Cell Biol</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>34</volume><issue>10</issue><spage>1184</spage><epage>1189</epage><pages>1184-1189</pages><issn>1357-2725</issn><eissn>1878-5875</eissn><abstract>ITK and Rlk/Txk are the predominant Tec family of tyrosine kinases expressed in T cells, and are involved in T cell antigen receptor mediated activation of T cells. 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| identifier | ISSN: 1357-2725 |
| ispartof | The international journal of biochemistry & cell biology, 2002-10, Vol.34 (10), p.1184-1189 |
| issn | 1357-2725 1878-5875 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | B cell activation BTK Enzyme Activation Humans ITK Protein Conformation Protein-Tyrosine Kinases - chemistry Protein-Tyrosine Kinases - metabolism Receptors, Antigen, T-Cell - metabolism Rlk Signal Transduction T cell activation T-Lymphocytes - enzymology Txk |
| title | The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals |
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