The relative role of peripheral blood and bone marrow for monitoring molecular evidence of disease in follicular lymphoma by quantitative real‐time polymerase chain reaction
Peripheral blood (PB) and bone marrow (BM) are used interchangeably for t(14;18) (IgH/BCL‐2) molecular monitoring in follicular lymphoma (FL) and detection of rearrangement after treatment has been correlated to increased risk of relapse. To determine the relative value of each tissue, MBR t(14;18)...
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| Veröffentlicht in: | British journal of haematology 2002-08, Vol.118 (2), p.563-566 |
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| container_title | British journal of haematology |
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| creator | Summers, Karin E. Davies, Andrew J. Matthews, Janet Jenner, Michael J. Cornelius, Victoria Amess, John A. Norton, Andrew J. Rohatiner, Ama Z. S. Fitzgibbon, Jude Lister, T. Andrew Goff, Lindsey K. |
| description | Peripheral blood (PB) and bone marrow (BM) are used interchangeably for t(14;18) (IgH/BCL‐2) molecular monitoring in follicular lymphoma (FL) and detection of rearrangement after treatment has been correlated to increased risk of relapse. To determine the relative value of each tissue, MBR t(14;18) was quantified by real‐time polymerase chain reaction in 52 simultaneous paired PB and BM samples from 38 FL patients. In total, 79% of sample pairs taken in remission (n = 19) or when no morphological disease was evident in the BM (n = 29) had t(14;18) copy number within one log difference and the median difference was small. These findings suggest that, in remission, PB may be adequately monitored. In general, however, higher copy number was detected in BM than in the corresponding PB sample. |
| doi_str_mv | 10.1046/j.1365-2141.2002.03641.x |
| format | Article |
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S. ; Fitzgibbon, Jude ; Lister, T. Andrew ; Goff, Lindsey K.</creator><creatorcontrib>Summers, Karin E. ; Davies, Andrew J. ; Matthews, Janet ; Jenner, Michael J. ; Cornelius, Victoria ; Amess, John A. ; Norton, Andrew J. ; Rohatiner, Ama Z. S. ; Fitzgibbon, Jude ; Lister, T. Andrew ; Goff, Lindsey K.</creatorcontrib><description>Peripheral blood (PB) and bone marrow (BM) are used interchangeably for t(14;18) (IgH/BCL‐2) molecular monitoring in follicular lymphoma (FL) and detection of rearrangement after treatment has been correlated to increased risk of relapse. To determine the relative value of each tissue, MBR t(14;18) was quantified by real‐time polymerase chain reaction in 52 simultaneous paired PB and BM samples from 38 FL patients. In total, 79% of sample pairs taken in remission (n = 19) or when no morphological disease was evident in the BM (n = 29) had t(14;18) copy number within one log difference and the median difference was small. These findings suggest that, in remission, PB may be adequately monitored. In general, however, higher copy number was detected in BM than in the corresponding PB sample.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.2002.03641.x</identifier><identifier>PMID: 12139746</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Blood ; Bone Marrow - pathology ; Chromosome Breakage ; Chromosomes, Human, Pair 14 - genetics ; Chromosomes, Human, Pair 18 - genetics ; follicular lymphoma ; Gene Rearrangement ; Hematology ; Humans ; Lymphoma, Follicular - genetics ; Lymphoma, Follicular - pathology ; monitoring ; Neoplasm, Residual ; Polymerase Chain Reaction - methods ; quantification ; real‐time PCR ; t(14;18)</subject><ispartof>British journal of haematology, 2002-08, Vol.118 (2), p.563-566</ispartof><rights>Copyright Blackwell Scientific Publications Ltd. Aug 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3921-17115f511f6eaeeb859dc7561dc3f9ce209cf79680e218baead7167c04bbe8c93</citedby><cites>FETCH-LOGICAL-c3921-17115f511f6eaeeb859dc7561dc3f9ce209cf79680e218baead7167c04bbe8c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2141.2002.03641.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2141.2002.03641.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27915,27916,45565,45566,46400,46824</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12139746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Summers, Karin E.</creatorcontrib><creatorcontrib>Davies, Andrew J.</creatorcontrib><creatorcontrib>Matthews, Janet</creatorcontrib><creatorcontrib>Jenner, Michael J.</creatorcontrib><creatorcontrib>Cornelius, Victoria</creatorcontrib><creatorcontrib>Amess, John A.</creatorcontrib><creatorcontrib>Norton, Andrew J.</creatorcontrib><creatorcontrib>Rohatiner, Ama Z. S.</creatorcontrib><creatorcontrib>Fitzgibbon, Jude</creatorcontrib><creatorcontrib>Lister, T. Andrew</creatorcontrib><creatorcontrib>Goff, Lindsey K.</creatorcontrib><title>The relative role of peripheral blood and bone marrow for monitoring molecular evidence of disease in follicular lymphoma by quantitative real‐time polymerase chain reaction</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Peripheral blood (PB) and bone marrow (BM) are used interchangeably for t(14;18) (IgH/BCL‐2) molecular monitoring in follicular lymphoma (FL) and detection of rearrangement after treatment has been correlated to increased risk of relapse. To determine the relative value of each tissue, MBR t(14;18) was quantified by real‐time polymerase chain reaction in 52 simultaneous paired PB and BM samples from 38 FL patients. In total, 79% of sample pairs taken in remission (n = 19) or when no morphological disease was evident in the BM (n = 29) had t(14;18) copy number within one log difference and the median difference was small. These findings suggest that, in remission, PB may be adequately monitored. In general, however, higher copy number was detected in BM than in the corresponding PB sample.</description><subject>Blood</subject><subject>Bone Marrow - pathology</subject><subject>Chromosome Breakage</subject><subject>Chromosomes, Human, Pair 14 - genetics</subject><subject>Chromosomes, Human, Pair 18 - genetics</subject><subject>follicular lymphoma</subject><subject>Gene Rearrangement</subject><subject>Hematology</subject><subject>Humans</subject><subject>Lymphoma, Follicular - genetics</subject><subject>Lymphoma, Follicular - pathology</subject><subject>monitoring</subject><subject>Neoplasm, Residual</subject><subject>Polymerase Chain Reaction - methods</subject><subject>quantification</subject><subject>real‐time PCR</subject><subject>t(14;18)</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAURS1ERaeFX0AWC3YZ_OLESRYsoCoUVKmbsrYc54XxyLFTO2k7Oz6BP-Gf-JI6nRGVWHXlK71z77PeJYQCWwMrxIftGrgosxwKWOeM5WvGRZL3L8jq3-AlWTHGqiwZ6mNyEuOWMeCshFfkGHLgTVWIFflzvUEa0KrJ3CbhLVLf0xGDGTcYlKWt9b6jynW09Q7poELwd7T3gQ7emckH434maVHPVgWKt6ZDpx9TOhNRRaTGJd5asyfsbhg3flC03dGbWbnJTIflqOzfX78nMyAdfcLS_uTWG5UC0lBPxrvX5KhXNuKbw3tKfnw5vz67yC6vvn47-3SZad7kkEEFUPYlQC9QIbZ12XS6KgV0mveNxpw1uq8aUTPMoW4Vqq4CUWlWtC3WuuGn5P0-dwz-ZsY4ycFEjdYqh36OsoKmSNflCXz3H7j1c3DpbxKatFaAyBNU7yEdfIwBezkGk065k8Dk0qjcyqU4uRQnl0blY6PyPlnfHvLndsDuyXioMAEf98Cdsbh7drD8_P1iUfwBVhm0jQ</recordid><startdate>200208</startdate><enddate>200208</enddate><creator>Summers, Karin E.</creator><creator>Davies, Andrew J.</creator><creator>Matthews, Janet</creator><creator>Jenner, Michael J.</creator><creator>Cornelius, Victoria</creator><creator>Amess, John A.</creator><creator>Norton, Andrew J.</creator><creator>Rohatiner, Ama Z. S.</creator><creator>Fitzgibbon, Jude</creator><creator>Lister, T. Andrew</creator><creator>Goff, Lindsey K.</creator><general>Blackwell Science Ltd</general><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200208</creationdate><title>The relative role of peripheral blood and bone marrow for monitoring molecular evidence of disease in follicular lymphoma by quantitative real‐time polymerase chain reaction</title><author>Summers, Karin E. ; Davies, Andrew J. ; Matthews, Janet ; Jenner, Michael J. ; Cornelius, Victoria ; Amess, John A. ; Norton, Andrew J. ; Rohatiner, Ama Z. S. ; Fitzgibbon, Jude ; Lister, T. Andrew ; Goff, Lindsey K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3921-17115f511f6eaeeb859dc7561dc3f9ce209cf79680e218baead7167c04bbe8c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Blood</topic><topic>Bone Marrow - pathology</topic><topic>Chromosome Breakage</topic><topic>Chromosomes, Human, Pair 14 - genetics</topic><topic>Chromosomes, Human, Pair 18 - genetics</topic><topic>follicular lymphoma</topic><topic>Gene Rearrangement</topic><topic>Hematology</topic><topic>Humans</topic><topic>Lymphoma, Follicular - genetics</topic><topic>Lymphoma, Follicular - pathology</topic><topic>monitoring</topic><topic>Neoplasm, Residual</topic><topic>Polymerase Chain Reaction - methods</topic><topic>quantification</topic><topic>real‐time PCR</topic><topic>t(14;18)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Summers, Karin E.</creatorcontrib><creatorcontrib>Davies, Andrew J.</creatorcontrib><creatorcontrib>Matthews, Janet</creatorcontrib><creatorcontrib>Jenner, Michael J.</creatorcontrib><creatorcontrib>Cornelius, Victoria</creatorcontrib><creatorcontrib>Amess, John A.</creatorcontrib><creatorcontrib>Norton, Andrew J.</creatorcontrib><creatorcontrib>Rohatiner, Ama Z. 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Andrew</au><au>Goff, Lindsey K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relative role of peripheral blood and bone marrow for monitoring molecular evidence of disease in follicular lymphoma by quantitative real‐time polymerase chain reaction</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2002-08</date><risdate>2002</risdate><volume>118</volume><issue>2</issue><spage>563</spage><epage>566</epage><pages>563-566</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><abstract>Peripheral blood (PB) and bone marrow (BM) are used interchangeably for t(14;18) (IgH/BCL‐2) molecular monitoring in follicular lymphoma (FL) and detection of rearrangement after treatment has been correlated to increased risk of relapse. To determine the relative value of each tissue, MBR t(14;18) was quantified by real‐time polymerase chain reaction in 52 simultaneous paired PB and BM samples from 38 FL patients. In total, 79% of sample pairs taken in remission (n = 19) or when no morphological disease was evident in the BM (n = 29) had t(14;18) copy number within one log difference and the median difference was small. These findings suggest that, in remission, PB may be adequately monitored. In general, however, higher copy number was detected in BM than in the corresponding PB sample.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>12139746</pmid><doi>10.1046/j.1365-2141.2002.03641.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Blood Bone Marrow - pathology Chromosome Breakage Chromosomes, Human, Pair 14 - genetics Chromosomes, Human, Pair 18 - genetics follicular lymphoma Gene Rearrangement Hematology Humans Lymphoma, Follicular - genetics Lymphoma, Follicular - pathology monitoring Neoplasm, Residual Polymerase Chain Reaction - methods quantification real‐time PCR t(14 18) |
| title | The relative role of peripheral blood and bone marrow for monitoring molecular evidence of disease in follicular lymphoma by quantitative real‐time polymerase chain reaction |
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