Rapid and simple quantitative assay method for diastereomeric flurbiprofen glucuronides in the incubation mixture

Acyl glucuronides of nonsteroidal anti-inflammatory drugs having a chiral center are known to be chemically very active and form covalently bound adducts with proteins, such as human serum albumin, which may be the cause of hypersensitive reactions. Hepatic acyl glucuronosyltransferase catalyzes the...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2002-08, Vol.776 (1), p.125-131
Hauptverfasser:	Mano, Nariyasu, Nikaido, Ayako, Narui, Takashi, Yamasaki, Daisuke, Goto, Junichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - analysis Anti-Inflammatory Agents, Non-Steroidal - chemistry Chromatography, High Pressure Liquid - methods Flurbiprofen - analysis Flurbiprofen - chemistry Flurbiprofen glucuronides Glucuronides - analysis Glucuronides - chemistry Hydrogen-Ion Concentration Reproducibility of Results Spectrophotometry, Ultraviolet Stereoisomerism
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