Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis
Compounds 1– 3 isolated from the methanolic extracts of Saururus chinensis root inhibited hACAT-1 and hACAT-2 activities. The EtOAc-soluble fraction, which contained compounds 1– 3, of methanol extracts of S. chinensis exhibited strong cholesterol-lowering effect in high cholesterol-fed mice. The se...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2004-06, Vol.14 (12), p.3109-3112 |
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| creator | Lee, Woo Song Lee, Dae-Woo Baek, Young-Il An, So-Jin Cho, Kyung-Hyun Choi, Yang-Kyu Kim, Hyoung-Chin Park, Ho-Yong Bae, Ki-Hwan Jeong, Tae-Sook |
| description | Compounds
1–
3 isolated from the methanolic extracts of
Saururus chinensis root inhibited hACAT-1 and hACAT-2 activities. The EtOAc-soluble fraction, which contained compounds
1–
3, of methanol extracts of
S. chinensis exhibited strong cholesterol-lowering effect in high cholesterol-fed mice.
The sesquineolignan, saucerneol B (
1), and dineolignans, manassantin A (
2), and manassantin B (
3), were isolated from the methanol extracts of
Saururus chinensis root and elucidated by their spectroscopic data analysis. Compounds
1–
3 inhibited hACAT-1 and hACAT-2 with IC
50 values of 43.0 and 124.0
μM for
1, of 39.0 and 8.0
μM for
2, of 82.0
μM and only 32% inhibition at 1
mM for
3, respectively. The EtOAc-soluble fraction, which contained compounds
1–
3, of methanol extracts of
S. chinensis exhibited strong cholesterol-lowering effect in high cholesterol-fed mice. |
| doi_str_mv | 10.1016/j.bmcl.2004.04.023 |
| format | Article |
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1–
3 isolated from the methanolic extracts of
Saururus chinensis root inhibited hACAT-1 and hACAT-2 activities. The EtOAc-soluble fraction, which contained compounds
1–
3, of methanol extracts of
S. chinensis exhibited strong cholesterol-lowering effect in high cholesterol-fed mice.
The sesquineolignan, saucerneol B (
1), and dineolignans, manassantin A (
2), and manassantin B (
3), were isolated from the methanol extracts of
Saururus chinensis root and elucidated by their spectroscopic data analysis. Compounds
1–
3 inhibited hACAT-1 and hACAT-2 with IC
50 values of 43.0 and 124.0
μM for
1, of 39.0 and 8.0
μM for
2, of 82.0
μM and only 32% inhibition at 1
mM for
3, respectively. The EtOAc-soluble fraction, which contained compounds
1–
3, of methanol extracts of
S. chinensis exhibited strong cholesterol-lowering effect in high cholesterol-fed mice.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2004.04.023</identifier><identifier>PMID: 15149654</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Enzyme Inhibitors - chemistry ; Enzyme Inhibitors - isolation & purification ; Enzyme Inhibitors - pharmacology ; Furans - chemistry ; Furans - isolation & purification ; Furans - pharmacology ; hACAT-1 and hACAT-2 ; Humans ; Hypocholesterolemic activity ; Inhibitor ; Lignans ; Lignans - chemistry ; Lignans - isolation & purification ; Lignans - pharmacology ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Miscellaneous ; Pharmacology. Drug treatments ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Roots ; S. chinensis ; Saururaceae ; Sterol O-Acyltransferase - antagonists & inhibitors ; Sterol O-Acyltransferase - metabolism ; Sterol O-Acyltransferase 2</subject><ispartof>Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3109-3112</ispartof><rights>2004 Elsevier Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-9897c51d4a35bc8b8eeef7032c1375e6facf03b57e9f9afcdbea86491440580f3</citedby><cites>FETCH-LOGICAL-c448t-9897c51d4a35bc8b8eeef7032c1375e6facf03b57e9f9afcdbea86491440580f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960894X04005219$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15770070$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15149654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Woo Song</creatorcontrib><creatorcontrib>Lee, Dae-Woo</creatorcontrib><creatorcontrib>Baek, Young-Il</creatorcontrib><creatorcontrib>An, So-Jin</creatorcontrib><creatorcontrib>Cho, Kyung-Hyun</creatorcontrib><creatorcontrib>Choi, Yang-Kyu</creatorcontrib><creatorcontrib>Kim, Hyoung-Chin</creatorcontrib><creatorcontrib>Park, Ho-Yong</creatorcontrib><creatorcontrib>Bae, Ki-Hwan</creatorcontrib><creatorcontrib>Jeong, Tae-Sook</creatorcontrib><title>Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>Compounds
1–
3 isolated from the methanolic extracts of
Saururus chinensis root inhibited hACAT-1 and hACAT-2 activities. The EtOAc-soluble fraction, which contained compounds
1–
3, of methanol extracts of
S. chinensis exhibited strong cholesterol-lowering effect in high cholesterol-fed mice.
The sesquineolignan, saucerneol B (
1), and dineolignans, manassantin A (
2), and manassantin B (
3), were isolated from the methanol extracts of
Saururus chinensis root and elucidated by their spectroscopic data analysis. Compounds
1–
3 inhibited hACAT-1 and hACAT-2 with IC
50 values of 43.0 and 124.0
μM for
1, of 39.0 and 8.0
μM for
2, of 82.0
μM and only 32% inhibition at 1
mM for
3, respectively. The EtOAc-soluble fraction, which contained compounds
1–
3, of methanol extracts of
S. chinensis exhibited strong cholesterol-lowering effect in high cholesterol-fed mice.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - isolation & purification</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Furans - chemistry</subject><subject>Furans - isolation & purification</subject><subject>Furans - pharmacology</subject><subject>hACAT-1 and hACAT-2</subject><subject>Humans</subject><subject>Hypocholesterolemic activity</subject><subject>Inhibitor</subject><subject>Lignans</subject><subject>Lignans - chemistry</subject><subject>Lignans - isolation & purification</subject><subject>Lignans - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Miscellaneous</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots</subject><subject>S. chinensis</subject><subject>Saururaceae</subject><subject>Sterol O-Acyltransferase - antagonists & inhibitors</subject><subject>Sterol O-Acyltransferase - metabolism</subject><subject>Sterol O-Acyltransferase 2</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo7uzoH_AguejJHpNO-iPgZXZwXWHBgyt4C9XpCpuhu7Omuhf235t2BvQkKcjleV-qHsbeSLGTQtYfj7tudMOuFELv1inVM7aRutaF0qJ6zjbC1KJojf55wS6JjkJILbR-yS5kJbWpK71h8WYZYeL7w_6ukBymnhclD9N96MIc0xMHN4fHMAckHj0nWBymCePArz7wHAQimOaQC_5kr3igOMCMPfcpjvw7LCk_4u4-TDhRoFfshYeB8PX537If15_vDjfF7bcvXw_728Jp3c6FaU3jKtlrUFXn2q5FRN8IVTqpmgprD84L1VUNGm_Au75DaGttpM6Xt8KrLXt_6n1I8deCNNsxkMNhgLz9QraRRrWqMRksT6BLkSihtw8pjJCerBR21WyPdtVsV812nVLl0Ntz-9KN2P-NnL1m4N0ZAHIw-ASTC_QP1zRC5Hu27NOJw-ziMWCy5AJODvuQ0M22j-F_e_wGBTebOg</recordid><startdate>20040621</startdate><enddate>20040621</enddate><creator>Lee, Woo Song</creator><creator>Lee, Dae-Woo</creator><creator>Baek, Young-Il</creator><creator>An, So-Jin</creator><creator>Cho, Kyung-Hyun</creator><creator>Choi, Yang-Kyu</creator><creator>Kim, Hyoung-Chin</creator><creator>Park, Ho-Yong</creator><creator>Bae, Ki-Hwan</creator><creator>Jeong, Tae-Sook</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040621</creationdate><title>Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis</title><author>Lee, Woo Song ; Lee, Dae-Woo ; Baek, Young-Il ; An, So-Jin ; Cho, Kyung-Hyun ; Choi, Yang-Kyu ; Kim, Hyoung-Chin ; Park, Ho-Yong ; Bae, Ki-Hwan ; Jeong, Tae-Sook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-9897c51d4a35bc8b8eeef7032c1375e6facf03b57e9f9afcdbea86491440580f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Enzyme Inhibitors - chemistry</topic><topic>Enzyme Inhibitors - isolation & purification</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Furans - chemistry</topic><topic>Furans - isolation & purification</topic><topic>Furans - pharmacology</topic><topic>hACAT-1 and hACAT-2</topic><topic>Humans</topic><topic>Hypocholesterolemic activity</topic><topic>Inhibitor</topic><topic>Lignans</topic><topic>Lignans - chemistry</topic><topic>Lignans - isolation & purification</topic><topic>Lignans - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Miscellaneous</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots</topic><topic>S. chinensis</topic><topic>Saururaceae</topic><topic>Sterol O-Acyltransferase - antagonists & inhibitors</topic><topic>Sterol O-Acyltransferase - metabolism</topic><topic>Sterol O-Acyltransferase 2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Woo Song</creatorcontrib><creatorcontrib>Lee, Dae-Woo</creatorcontrib><creatorcontrib>Baek, Young-Il</creatorcontrib><creatorcontrib>An, So-Jin</creatorcontrib><creatorcontrib>Cho, Kyung-Hyun</creatorcontrib><creatorcontrib>Choi, Yang-Kyu</creatorcontrib><creatorcontrib>Kim, Hyoung-Chin</creatorcontrib><creatorcontrib>Park, Ho-Yong</creatorcontrib><creatorcontrib>Bae, Ki-Hwan</creatorcontrib><creatorcontrib>Jeong, Tae-Sook</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Woo Song</au><au>Lee, Dae-Woo</au><au>Baek, Young-Il</au><au>An, So-Jin</au><au>Cho, Kyung-Hyun</au><au>Choi, Yang-Kyu</au><au>Kim, Hyoung-Chin</au><au>Park, Ho-Yong</au><au>Bae, Ki-Hwan</au><au>Jeong, Tae-Sook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2004-06-21</date><risdate>2004</risdate><volume>14</volume><issue>12</issue><spage>3109</spage><epage>3112</epage><pages>3109-3112</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>Compounds
1–
3 isolated from the methanolic extracts of
Saururus chinensis root inhibited hACAT-1 and hACAT-2 activities. The EtOAc-soluble fraction, which contained compounds
1–
3, of methanol extracts of
S. chinensis exhibited strong cholesterol-lowering effect in high cholesterol-fed mice.
The sesquineolignan, saucerneol B (
1), and dineolignans, manassantin A (
2), and manassantin B (
3), were isolated from the methanol extracts of
Saururus chinensis root and elucidated by their spectroscopic data analysis. Compounds
1–
3 inhibited hACAT-1 and hACAT-2 with IC
50 values of 43.0 and 124.0
μM for
1, of 39.0 and 8.0
μM for
2, of 82.0
μM and only 32% inhibition at 1
mM for
3, respectively. The EtOAc-soluble fraction, which contained compounds
1–
3, of methanol extracts of
S. chinensis exhibited strong cholesterol-lowering effect in high cholesterol-fed mice.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15149654</pmid><doi>10.1016/j.bmcl.2004.04.023</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3109-3112 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71938379 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Furans - chemistry Furans - isolation & purification Furans - pharmacology hACAT-1 and hACAT-2 Humans Hypocholesterolemic activity Inhibitor Lignans Lignans - chemistry Lignans - isolation & purification Lignans - pharmacology Male Medical sciences Mice Mice, Inbred C57BL Miscellaneous Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Roots S. chinensis Saururaceae Sterol O-Acyltransferase - antagonists & inhibitors Sterol O-Acyltransferase - metabolism Sterol O-Acyltransferase 2 |
| title | Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis |
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