Phenytoin Blocks Retinal Ganglion Cell Death After Partial Optic Nerve Crush

Phenytoin is a well-characterized sodium channel blocker in widespread use as an anticonvulsant. In 1972, Becker and co-workers reported that phenytoin could reverse visual field loss from glaucoma. The authors therefore explored whether phenytoin could protect retinal ganglion cells from optic nerv...

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Veröffentlicht in:	Experimental eye research 2002-06, Vol.74 (6), p.747-752
Hauptverfasser:	Naskar, Rita, Quinto, Kristine, Romann, Ilka, Schuettauf, Frank, Zurakowski, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences Calcium - metabolism Cell Death - drug effects Cell Survival - drug effects Drug Therapy, Combination Excitatory Amino Acid Antagonists - therapeutic use Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology memantine Memantine - therapeutic use Nerve Crush neuroprotection Neuroprotective Agents - therapeutic use Optic Nerve Injuries - drug therapy Optic Nerve Injuries - metabolism Optic Nerve Injuries - pathology phenytoin Phenytoin - therapeutic use Rats Rats, Long-Evans retina retinal ganglion cells Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - pathology Vertebrates: nervous system and sense organs
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