FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress

Members of the FOXO family of mammalian forkhead transcription factors, including AFX, FKHRL1, and FKHR, are homologs of DAF-16, which regulates genes that contribute both to longevity and to resistance to various stresses (including oxidative stress) in Caenorhabditis elegans. We have generated mou...

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Veröffentlicht in:	The Journal of biological chemistry 2002-07, Vol.277 (30), p.26729-26732
Hauptverfasser:	Furukawa-Hibi, Yoko, Yoshida-Araki, Kiyomi, Ohta, Tsutomu, Ikeda, Kyoji, Motoyama, Noboru
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Blotting, Northern Cell Cycle Cell Cycle Proteins Cell Line DNA, Complementary - metabolism DNA-Binding Proteins - physiology Epitopes Forkhead Box Protein O1 Forkhead Box Protein O3 Forkhead Transcription Factors G2 Phase GADD45 Proteins HeLa Cells Humans Immunoblotting Intracellular Signaling Peptides and Proteins Luciferases - metabolism Mice Mitosis Oligonucleotide Array Sequence Analysis Oxidative Stress Phosphorylation Plasmids - metabolism Promoter Regions, Genetic Proteins - metabolism Time Factors Transcription Factors - metabolism Transcription Factors - physiology
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