The effect of poly(ethylene glycol) molecular architecture on cellular interaction and uptake of DNA complexes

The cellular uptake of plasmid DNA complexes with a series of tertiary amine methacrylate-ethylene glycol (DMAEMA-EG) copolymers with various architectures was studied using flow cytofluorometry and laser confocal microscopy. The complexes displayed different rates and extents of cellular interactio...

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Veröffentlicht in:	Journal of controlled release 2004-05, Vol.97 (1), p.143-156
Hauptverfasser:	Deshpande, Mangesh C., Davies, Martyn C., Garnett, Martin C., Williams, Philip M., Armitage, David, Bailey, Lindsey, Vamvakaki, Maria, Armes, Steven P., Stolnik, Snjezana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Communication - drug effects Cell Communication - physiology Cercopithecus aethiops Confocal microscopy COS Cells DNA - metabolism Flow cytometry General pharmacology Humans Medical sciences Non-viral gene delivery PEG copolymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Polymer complexes
Online-Zugang:	Volltext
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