Differential expression of the Drosophila mitofusin genes fuzzy onions ( fzo) and dmfn
Mitofusins comprise a family of evolutionarily conserved, nuclear encoded mitochondrial guanosine triphoshatases that control mitochondrial fusion and morphology. The fuzzy onions ( fzo) and Drosophila mitofusin ( dmfn) genes, which encode the only Mitofusin homologs in Drosophila are differentially...
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| Veröffentlicht in: | Mechanisms of development 2002-08, Vol.116 (1), p.213-216 |
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| creator | Hwa, Jennifer J. Hiller, Mark A. Fuller, Margaret T. Santel, Ansgar |
| description | Mitofusins comprise a family of evolutionarily conserved, nuclear encoded mitochondrial guanosine triphoshatases that control mitochondrial fusion and morphology. The
fuzzy onions (
fzo) and
Drosophila mitofusin (
dmfn) genes, which encode the only Mitofusin homologs in
Drosophila are differentially expressed during development.
Dmfn-mRNA was widely expressed during embryogenesis accumulating in the mesoderm and endoderm during gut development, during oogenesis with transcripts maternally deposited into the early embryo and in the male germ line, where
dmfn-mRNA was expressed in spermatogonia, spermatocytes and early spermatids. In contrast, expression of the
fzo was tightly restricted to the male germ line, with mRNA accumulation in spermatocytes and early spermatids. In addition, expression of
dmfn and
fzo in the same cell type, primary spermatocytes, was under control of different regulatory mechanisms. |
| doi_str_mv | 10.1016/S0925-4773(02)00141-7 |
| format | Article |
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fuzzy onions (
fzo) and
Drosophila mitofusin (
dmfn) genes, which encode the only Mitofusin homologs in
Drosophila are differentially expressed during development.
Dmfn-mRNA was widely expressed during embryogenesis accumulating in the mesoderm and endoderm during gut development, during oogenesis with transcripts maternally deposited into the early embryo and in the male germ line, where
dmfn-mRNA was expressed in spermatogonia, spermatocytes and early spermatids. In contrast, expression of the
fzo was tightly restricted to the male germ line, with mRNA accumulation in spermatocytes and early spermatids. In addition, expression of
dmfn and
fzo in the same cell type, primary spermatocytes, was under control of different regulatory mechanisms.</description><identifier>ISSN: 0925-4773</identifier><identifier>EISSN: 1872-6356</identifier><identifier>DOI: 10.1016/S0925-4773(02)00141-7</identifier><identifier>PMID: 12128227</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Cannonball ; CG3869 ; Digestive System - embryology ; Digestive System - metabolism ; Drosophila ; Drosophila - enzymology ; Drosophila - genetics ; Drosophila - growth & development ; Drosophila Proteins - genetics ; Embryogenesis ; Female ; Gene Expression Regulation, Developmental ; Genes, Insect ; GTP Phosphohydrolases - genetics ; Guanosine triphosphatase ; Gut development ; In Situ Hybridization ; Male ; Membrane Proteins - genetics ; Mitochondria ; Mitochondrial fusion ; Mitochondrial morphology ; Mitochondrial Proteins - genetics ; Mitofusin ; Nebenkern ; Oogenesis ; Oogenesis - genetics ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Spermatogenesis ; Spermatogenesis - genetics ; TAFs ; Transcription</subject><ispartof>Mechanisms of development, 2002-08, Vol.116 (1), p.213-216</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-ae9d3cdbded8dac4ed84d0acdca4dd461fe4f397b9e9a57e54d6a295e3eaf6a13</citedby><cites>FETCH-LOGICAL-c413t-ae9d3cdbded8dac4ed84d0acdca4dd461fe4f397b9e9a57e54d6a295e3eaf6a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0925-4773(02)00141-7$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12128227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwa, Jennifer J.</creatorcontrib><creatorcontrib>Hiller, Mark A.</creatorcontrib><creatorcontrib>Fuller, Margaret T.</creatorcontrib><creatorcontrib>Santel, Ansgar</creatorcontrib><title>Differential expression of the Drosophila mitofusin genes fuzzy onions ( fzo) and dmfn</title><title>Mechanisms of development</title><addtitle>Mech Dev</addtitle><description>Mitofusins comprise a family of evolutionarily conserved, nuclear encoded mitochondrial guanosine triphoshatases that control mitochondrial fusion and morphology. The
fuzzy onions (
fzo) and
Drosophila mitofusin (
dmfn) genes, which encode the only Mitofusin homologs in
Drosophila are differentially expressed during development.
Dmfn-mRNA was widely expressed during embryogenesis accumulating in the mesoderm and endoderm during gut development, during oogenesis with transcripts maternally deposited into the early embryo and in the male germ line, where
dmfn-mRNA was expressed in spermatogonia, spermatocytes and early spermatids. In contrast, expression of the
fzo was tightly restricted to the male germ line, with mRNA accumulation in spermatocytes and early spermatids. In addition, expression of
dmfn and
fzo in the same cell type, primary spermatocytes, was under control of different regulatory mechanisms.</description><subject>Animals</subject><subject>Cannonball</subject><subject>CG3869</subject><subject>Digestive System - embryology</subject><subject>Digestive System - metabolism</subject><subject>Drosophila</subject><subject>Drosophila - enzymology</subject><subject>Drosophila - genetics</subject><subject>Drosophila - growth & development</subject><subject>Drosophila Proteins - genetics</subject><subject>Embryogenesis</subject><subject>Female</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes, Insect</subject><subject>GTP Phosphohydrolases - genetics</subject><subject>Guanosine triphosphatase</subject><subject>Gut development</subject><subject>In Situ Hybridization</subject><subject>Male</subject><subject>Membrane Proteins - genetics</subject><subject>Mitochondria</subject><subject>Mitochondrial fusion</subject><subject>Mitochondrial morphology</subject><subject>Mitochondrial Proteins - genetics</subject><subject>Mitofusin</subject><subject>Nebenkern</subject><subject>Oogenesis</subject><subject>Oogenesis - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Spermatogenesis</subject><subject>Spermatogenesis - genetics</subject><subject>TAFs</subject><subject>Transcription</subject><issn>0925-4773</issn><issn>1872-6356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAUhS0EouXxE0CeUBkCtuPEzYRQeUqVGHislmtfU6PELnaCaH89gVYwMp3lu_fofAgdUXJGCS3PH0nFiowLkY8IOyWEcpqJLTSkY8GyMi_KbTT8RQZoL6U30lO0pLtoQBllY8bEEL1cOWshgm-dqjF8LiKk5ILHweJ2DvgqhhQWc1cr3Lg22C45j1_BQ8K2W62WOPieTniE7SqcYuUNNo31B2jHqjrB4Sb30fPN9dPkLps-3N5PLqeZ5jRvMwWVybWZGTBjozTvgxuitNGKG8NLaoHbvBKzCipVCCi4KRWrCshB2VLRfB-drP8uYnjvILWycUlDXSsPoUtS0CrnnJEeLNag7gelCFYuomtUXEpK5LdQ-SNUftuShMkfoVL0d8ebgm7WgPm72hjsgYs1AP3MDwdRJu3AazAugm6lCe6fii8_Goea</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>Hwa, Jennifer J.</creator><creator>Hiller, Mark A.</creator><creator>Fuller, Margaret T.</creator><creator>Santel, Ansgar</creator><general>Elsevier Ireland Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>Differential expression of the Drosophila mitofusin genes fuzzy onions ( fzo) and dmfn</title><author>Hwa, Jennifer J. ; Hiller, Mark A. ; Fuller, Margaret T. ; Santel, Ansgar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-ae9d3cdbded8dac4ed84d0acdca4dd461fe4f397b9e9a57e54d6a295e3eaf6a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Cannonball</topic><topic>CG3869</topic><topic>Digestive System - embryology</topic><topic>Digestive System - metabolism</topic><topic>Drosophila</topic><topic>Drosophila - enzymology</topic><topic>Drosophila - genetics</topic><topic>Drosophila - growth & development</topic><topic>Drosophila Proteins - genetics</topic><topic>Embryogenesis</topic><topic>Female</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes, Insect</topic><topic>GTP Phosphohydrolases - genetics</topic><topic>Guanosine triphosphatase</topic><topic>Gut development</topic><topic>In Situ Hybridization</topic><topic>Male</topic><topic>Membrane Proteins - genetics</topic><topic>Mitochondria</topic><topic>Mitochondrial fusion</topic><topic>Mitochondrial morphology</topic><topic>Mitochondrial Proteins - genetics</topic><topic>Mitofusin</topic><topic>Nebenkern</topic><topic>Oogenesis</topic><topic>Oogenesis - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Spermatogenesis</topic><topic>Spermatogenesis - genetics</topic><topic>TAFs</topic><topic>Transcription</topic><toplevel>online_resources</toplevel><creatorcontrib>Hwa, Jennifer J.</creatorcontrib><creatorcontrib>Hiller, Mark A.</creatorcontrib><creatorcontrib>Fuller, Margaret T.</creatorcontrib><creatorcontrib>Santel, Ansgar</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwa, Jennifer J.</au><au>Hiller, Mark A.</au><au>Fuller, Margaret T.</au><au>Santel, Ansgar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential expression of the Drosophila mitofusin genes fuzzy onions ( fzo) and dmfn</atitle><jtitle>Mechanisms of development</jtitle><addtitle>Mech Dev</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>116</volume><issue>1</issue><spage>213</spage><epage>216</epage><pages>213-216</pages><issn>0925-4773</issn><eissn>1872-6356</eissn><abstract>Mitofusins comprise a family of evolutionarily conserved, nuclear encoded mitochondrial guanosine triphoshatases that control mitochondrial fusion and morphology. The
fuzzy onions (
fzo) and
Drosophila mitofusin (
dmfn) genes, which encode the only Mitofusin homologs in
Drosophila are differentially expressed during development.
Dmfn-mRNA was widely expressed during embryogenesis accumulating in the mesoderm and endoderm during gut development, during oogenesis with transcripts maternally deposited into the early embryo and in the male germ line, where
dmfn-mRNA was expressed in spermatogonia, spermatocytes and early spermatids. In contrast, expression of the
fzo was tightly restricted to the male germ line, with mRNA accumulation in spermatocytes and early spermatids. In addition, expression of
dmfn and
fzo in the same cell type, primary spermatocytes, was under control of different regulatory mechanisms.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>12128227</pmid><doi>10.1016/S0925-4773(02)00141-7</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Cannonball CG3869 Digestive System - embryology Digestive System - metabolism Drosophila Drosophila - enzymology Drosophila - genetics Drosophila - growth & development Drosophila Proteins - genetics Embryogenesis Female Gene Expression Regulation, Developmental Genes, Insect GTP Phosphohydrolases - genetics Guanosine triphosphatase Gut development In Situ Hybridization Male Membrane Proteins - genetics Mitochondria Mitochondrial fusion Mitochondrial morphology Mitochondrial Proteins - genetics Mitofusin Nebenkern Oogenesis Oogenesis - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Spermatogenesis Spermatogenesis - genetics TAFs Transcription |
| title | Differential expression of the Drosophila mitofusin genes fuzzy onions ( fzo) and dmfn |
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