Specific cleavage of β-amyloid peptides by a metallopeptidase from Xenopus laevis skin secretions

Dactylysin (EC 3.5.24.60) is a metalloendopeptidase first isolated from the skin granular gland secretions of Xenopus laevis. This peptidase hydrolyzes bonds on the amino-terminus of singlets and between doublets of hydrophobic amino acids and was considered to play a role in the in vivo inactivatio...

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Veröffentlicht in:	Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2002-08, Vol.132 (4), p.751-759
Hauptverfasser:	Clamagirand, Christine, Joulie, Catherine, Panchal, Maı̈, Sekhri, Redha, Hanquez, Chantal, Cohen, Paul, Rholam, Mohamed
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloid protein precursor Animals Bodily Secretions - enzymology Dactylysin Endopeptidase Humans Metalloendopeptidases - isolation & purification Metalloendopeptidases - metabolism Peptide Fragments - genetics Peptide Fragments - metabolism Peptides - genetics Peptides - metabolism Protease Inhibitors - metabolism Skin - enzymology Skin - secretion Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Xenopus laevis Xenopus laevis - metabolism Xenopus Proteins - isolation & purification Xenopus Proteins - metabolism Zinc - metabolism β[1-40]-amyloid peptide
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