Aromatization of 16alpha-hydroxyandrostenedione by human placental microsomes: effect of preincubation with suicide substrates of androstenedione aromatization

Estrogen synthase (aromatase) catalyzes the aromatization of androstenedione (AD) as well as 16alpha-hydroxyandrostenedione (16alpha-OHAD) leading to estrone and estriol, respectively. We found that several steroid analogs including 4-hydroxyandrostenedione (1), 6-oxoandrostenedione (6-oxoAD, 2) and...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2002-06, Vol.81 (2), p.165-172
Hauptverfasser:	Numazawa, Mitsuteru, Tachibana, Mii, Mutsumi, Ayako, Yoshimura, Akiko, Osawa, Yoshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstenedione - analogs & derivatives Androstenedione - metabolism Aromatase - metabolism Female Humans Microsomes - enzymology Microsomes - metabolism Placenta - enzymology Placenta - metabolism Pregnancy
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