Cytoplasmic localization of calcium/calmodulin-dependent protein kinase I-α depends on a nuclear export signal in its regulatory domain

Calcium/calmodulin-dependent protein kinase I-α (CaMKI-α) is a ubiquitous cytosolic enzyme that phosphorylates a number of nuclear proteins in vitro and has been implicated in transcriptional regulation. We report that cytoplasmic localization of CaMKI-α depends on CRM1-mediated nuclear export media...

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Veröffentlicht in:	FEBS letters 2004-05, Vol.566 (1), p.275-280
Hauptverfasser:	Stedman, Diann R., Uboha, Nataliya V., Stedman, Timothy T., Nairn, Angus C., Picciotto, Marina R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - physiology Animals Ca2+, calcium Calcium-Calmodulin-Dependent Protein Kinase Type 1 Calcium-Calmodulin-Dependent Protein Kinases - chemistry Calcium-Calmodulin-Dependent Protein Kinases - genetics Calcium-Calmodulin-Dependent Protein Kinases - metabolism Calcium/calmodulin-dependent protein kinase I CaM, calmodulin CaMK, calcium/calmodulin-dependent protein kinase Consensus Sequence CRM1 Cytoplasm - metabolism Enzyme Activation Exportin 1 Protein GFP Karyopherins Leptomycin B LMB, leptomycin B Microscopy, Fluorescence NES, nuclear export signal NLS, nuclear localization signal Nuclear export Nuclear Localization Signals - genetics Nuclear Localization Signals - metabolism PC12 cell PC12 Cells Protein Structure, Tertiary Rats Receptors, Cytoplasmic and Nuclear Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Subcellular Fractions - metabolism Transfection
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