Activation of phospholipase D by osmotic cell swelling
In response to osmotic cell swelling, Intestine 407 cells react with a rapid and transient activation of phospholipase D (PLD). To investigate the role of PLD during the regulatory volume decrease, cells were treated with 1-butanol resulting in a depletion of PLD substrates. Activation of volume-reg...
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| Veröffentlicht in: | FEBS letters 2004-05, Vol.566 (1), p.287-290 |
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| creator | Tomassen, Sebastian F.B. van der Wijk, Thea de Jonge, Hugo R. Tilly, Ben C. |
| description | In response to osmotic cell swelling, Intestine 407 cells react with a rapid and transient activation of phospholipase D (PLD). To investigate the role of PLD during the regulatory volume decrease, cells were treated with 1-butanol resulting in a depletion of PLD substrates. Activation of volume-regulated anion channels, but not the cell swelling-induced release of taurine, was largely inhibited in the presence of low concentrations of 1-butanol. In addition, hypotonicity-induced exocytosis, ATP release and subsequent endocytosis were found to be largely abrogated. The results support a model of cell volume regulation in which PLD plays an essential role in the cell swelling-induced vesicle cycling and in the activation of volume-sensitive anion channels. |
| doi_str_mv | 10.1016/j.febslet.2004.04.063 |
| format | Article |
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To investigate the role of PLD during the regulatory volume decrease, cells were treated with 1-butanol resulting in a depletion of PLD substrates. Activation of volume-regulated anion channels, but not the cell swelling-induced release of taurine, was largely inhibited in the presence of low concentrations of 1-butanol. In addition, hypotonicity-induced exocytosis, ATP release and subsequent endocytosis were found to be largely abrogated. 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To investigate the role of PLD during the regulatory volume decrease, cells were treated with 1-butanol resulting in a depletion of PLD substrates. Activation of volume-regulated anion channels, but not the cell swelling-induced release of taurine, was largely inhibited in the presence of low concentrations of 1-butanol. In addition, hypotonicity-induced exocytosis, ATP release and subsequent endocytosis were found to be largely abrogated. The results support a model of cell volume regulation in which PLD plays an essential role in the cell swelling-induced vesicle cycling and in the activation of volume-sensitive anion channels.</description><subject>1-Butanol - pharmacology</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>ATP release</subject><subject>Cell Line</subject><subject>Cell Size - drug effects</subject><subject>Cell Size - physiology</subject><subject>Chloride channel</subject><subject>Dextrans - chemistry</subject><subject>Dextrans - metabolism</subject><subject>Enzyme Activation</subject><subject>Exocytosis</subject><subject>Humans</subject><subject>Hypotonic Solutions - pharmacology</subject><subject>Intestines - cytology</subject><subject>Microscopy, Fluorescence</subject><subject>Osmotic Pressure</subject><subject>Phospholipase D</subject><subject>Phospholipase D - metabolism</subject><subject>Phospholipids - metabolism</subject><subject>Radioisotopes</subject><subject>Regulatory volume decrease</subject><subject>Taurine</subject><subject>Taurine - metabolism</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1LxDAQhoMoun78BKUnb11nTJo0J9H1EwQPKngLaTLVLN3N2nSV_fe27IJHhflg4J13hoexY4QxAsqz6bimKjXUjc8BxHgIybfYCEvFcy5kuc1GACjyQmm-x_ZTmkI_l6h32R4WKJRGGDF56brwZbsQ51mss8VHTH02YWETZddZtcpimsUuuMxR02Tpu69h_n7IdmrbJDra9AP2envzMrnPH5_uHiaXj7kTir_lCjRyVUlZSats5bjXqiZEKMhK9KCt5N66UrsCyZdApa2lF-itBC2F5gfsdO27aOPnklJnZiENn9g5xWUyCjXnyAdhsRa6NqbUUm0WbZjZdmUQzADMTM0GmBmAmSEk7_dONgeW1Yz879aGUC-4Xwu-Q0Or_7ma25ur8-eB_gAfBEAh4K23ulhbUU_sK1Brkgs0d-RDS64zPoY_vv0BWK-T5w</recordid><startdate>20040521</startdate><enddate>20040521</enddate><creator>Tomassen, Sebastian F.B.</creator><creator>van der Wijk, Thea</creator><creator>de Jonge, Hugo R.</creator><creator>Tilly, Ben C.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040521</creationdate><title>Activation of phospholipase D by osmotic cell swelling</title><author>Tomassen, Sebastian F.B. ; van der Wijk, Thea ; de Jonge, Hugo R. ; Tilly, Ben C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473X-709137b66b6a7abc3d97fe1105ea61d09a63dac89c51ed80e8af6d41da6096493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>1-Butanol - pharmacology</topic><topic>Adenosine Triphosphate - metabolism</topic><topic>ATP release</topic><topic>Cell Line</topic><topic>Cell Size - drug effects</topic><topic>Cell Size - physiology</topic><topic>Chloride channel</topic><topic>Dextrans - chemistry</topic><topic>Dextrans - metabolism</topic><topic>Enzyme Activation</topic><topic>Exocytosis</topic><topic>Humans</topic><topic>Hypotonic Solutions - pharmacology</topic><topic>Intestines - cytology</topic><topic>Microscopy, Fluorescence</topic><topic>Osmotic Pressure</topic><topic>Phospholipase D</topic><topic>Phospholipase D - metabolism</topic><topic>Phospholipids - metabolism</topic><topic>Radioisotopes</topic><topic>Regulatory volume decrease</topic><topic>Taurine</topic><topic>Taurine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomassen, Sebastian F.B.</creatorcontrib><creatorcontrib>van der Wijk, Thea</creatorcontrib><creatorcontrib>de Jonge, Hugo R.</creatorcontrib><creatorcontrib>Tilly, Ben C.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomassen, Sebastian F.B.</au><au>van der Wijk, Thea</au><au>de Jonge, Hugo R.</au><au>Tilly, Ben C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of phospholipase D by osmotic cell swelling</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2004-05-21</date><risdate>2004</risdate><volume>566</volume><issue>1</issue><spage>287</spage><epage>290</epage><pages>287-290</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>In response to osmotic cell swelling, Intestine 407 cells react with a rapid and transient activation of phospholipase D (PLD). To investigate the role of PLD during the regulatory volume decrease, cells were treated with 1-butanol resulting in a depletion of PLD substrates. Activation of volume-regulated anion channels, but not the cell swelling-induced release of taurine, was largely inhibited in the presence of low concentrations of 1-butanol. In addition, hypotonicity-induced exocytosis, ATP release and subsequent endocytosis were found to be largely abrogated. The results support a model of cell volume regulation in which PLD plays an essential role in the cell swelling-induced vesicle cycling and in the activation of volume-sensitive anion channels.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>15147910</pmid><doi>10.1016/j.febslet.2004.04.063</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 1-Butanol - pharmacology Adenosine Triphosphate - metabolism ATP release Cell Line Cell Size - drug effects Cell Size - physiology Chloride channel Dextrans - chemistry Dextrans - metabolism Enzyme Activation Exocytosis Humans Hypotonic Solutions - pharmacology Intestines - cytology Microscopy, Fluorescence Osmotic Pressure Phospholipase D Phospholipase D - metabolism Phospholipids - metabolism Radioisotopes Regulatory volume decrease Taurine Taurine - metabolism |
| title | Activation of phospholipase D by osmotic cell swelling |
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