Protection against Challenge with Measles Virus (MV) in Infant Macaques by an MV DNA Vaccine Administered in the Presence of Neutralizing Antibody
Measles virus (MV) infection is the major cause of vaccine-preventable death in infants and children worldwide. It is difficult to achieve immunity to MV infection by use of vaccines in infants during the first 6–9 months of life because of the presence of maternal antibody. Morbidity and mortality...
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| Veröffentlicht in: | The Journal of infectious diseases 2004-06, Vol.189 (11), p.2064-2071 |
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| container_title | The Journal of infectious diseases |
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| creator | Premenko-Lanier, Mary Rota, Paul A. Rhodes, Gary H. Bellini, William J. McChesney, Michael B. |
| description | Measles virus (MV) infection is the major cause of vaccine-preventable death in infants and children worldwide. It is difficult to achieve immunity to MV infection by use of vaccines in infants during the first 6–9 months of life because of the presence of maternal antibody. Morbidity and mortality due to MV infection would decrease substantially if a vaccine administered at birth could prime immunity in the presence of maternal antibody.We demonstrate here that an MV DNA vaccine administered to infant macaques in the presence of maternal antibody primes MV-specific T cell responses but not de novo neutralizing antibody. This vaccine protected 80% of the infant macaques from skin rash and MV-induced immunosuppression. A molecular interleukin-2 adjuvant was required for protection with this vaccine. This macaque model shows that infants can be vaccinated against MV in the presence of maternal antibody. These results suggest that it is possible to develop an MV DNA vaccine that could protect infants in developing countries during the first months of life. |
| doi_str_mv | 10.1086/420792 |
| format | Article |
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It is difficult to achieve immunity to MV infection by use of vaccines in infants during the first 6–9 months of life because of the presence of maternal antibody. Morbidity and mortality due to MV infection would decrease substantially if a vaccine administered at birth could prime immunity in the presence of maternal antibody.We demonstrate here that an MV DNA vaccine administered to infant macaques in the presence of maternal antibody primes MV-specific T cell responses but not de novo neutralizing antibody. This vaccine protected 80% of the infant macaques from skin rash and MV-induced immunosuppression. A molecular interleukin-2 adjuvant was required for protection with this vaccine. This macaque model shows that infants can be vaccinated against MV in the presence of maternal antibody. These results suggest that it is possible to develop an MV DNA vaccine that could protect infants in developing countries during the first months of life.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/420792</identifier><identifier>PMID: 15143474</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University Chicago Press</publisher><subject>Adjuvants, Immunologic ; Animals ; Animals, Newborn ; Antibodies ; Antibodies, Viral - immunology ; Biological and medical sciences ; Disease Models, Animal ; DNA ; DNA vaccines ; Enzyme-Linked Immunosorbent Assay ; Female ; Fundamental and applied biological sciences. Psychology ; Immunity ; Immunoglobulin G - immunology ; Infants ; Infectious diseases ; Interleukin-2 - immunology ; Macaca mulatta ; Male ; Measles ; Measles - immunology ; Measles - prevention & control ; Measles - virology ; Measles Vaccine - immunology ; Measles Vaccine - therapeutic use ; Measles virus ; Measles virus - genetics ; Measles virus - immunology ; Medical sciences ; Microbiology ; Miscellaneous ; Neutralization Tests ; Plasmids ; Plasmids - immunology ; T lymphocytes ; Tetanus toxoid ; Tetanus Toxoid - immunology ; Vaccination ; Vaccines, DNA - immunology ; Vaccines, DNA - therapeutic use ; Viremia - immunology ; Virology ; Viruses</subject><ispartof>The Journal of infectious diseases, 2004-06, Vol.189 (11), p.2064-2071</ispartof><rights>Copyright 2004 Infectious Diseases Society of America</rights><rights>2004 by the Infectious Diseases Society of America 2004</rights><rights>2004 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Jun 1 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-29e4d8025ad0e92c4d4af87c207ab5e39996e941aadf9a5351aa79d8680e99203</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30076813$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30076813$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15913859$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15143474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Premenko-Lanier, Mary</creatorcontrib><creatorcontrib>Rota, Paul A.</creatorcontrib><creatorcontrib>Rhodes, Gary H.</creatorcontrib><creatorcontrib>Bellini, William J.</creatorcontrib><creatorcontrib>McChesney, Michael B.</creatorcontrib><title>Protection against Challenge with Measles Virus (MV) in Infant Macaques by an MV DNA Vaccine Administered in the Presence of Neutralizing Antibody</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Measles virus (MV) infection is the major cause of vaccine-preventable death in infants and children worldwide. It is difficult to achieve immunity to MV infection by use of vaccines in infants during the first 6–9 months of life because of the presence of maternal antibody. Morbidity and mortality due to MV infection would decrease substantially if a vaccine administered at birth could prime immunity in the presence of maternal antibody.We demonstrate here that an MV DNA vaccine administered to infant macaques in the presence of maternal antibody primes MV-specific T cell responses but not de novo neutralizing antibody. This vaccine protected 80% of the infant macaques from skin rash and MV-induced immunosuppression. A molecular interleukin-2 adjuvant was required for protection with this vaccine. This macaque model shows that infants can be vaccinated against MV in the presence of maternal antibody. These results suggest that it is possible to develop an MV DNA vaccine that could protect infants in developing countries during the first months of life.</description><subject>Adjuvants, Immunologic</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Antibodies</subject><subject>Antibodies, Viral - immunology</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>DNA</subject><subject>DNA vaccines</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunity</subject><subject>Immunoglobulin G - immunology</subject><subject>Infants</subject><subject>Infectious diseases</subject><subject>Interleukin-2 - immunology</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>Measles</subject><subject>Measles - immunology</subject><subject>Measles - prevention & control</subject><subject>Measles - virology</subject><subject>Measles Vaccine - immunology</subject><subject>Measles Vaccine - therapeutic use</subject><subject>Measles virus</subject><subject>Measles virus - genetics</subject><subject>Measles virus - immunology</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Neutralization Tests</subject><subject>Plasmids</subject><subject>Plasmids - immunology</subject><subject>T lymphocytes</subject><subject>Tetanus toxoid</subject><subject>Tetanus Toxoid - immunology</subject><subject>Vaccination</subject><subject>Vaccines, DNA - immunology</subject><subject>Vaccines, DNA - therapeutic use</subject><subject>Viremia - immunology</subject><subject>Virology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c2O0zAQB_AIgdiywBuADBIIDgF_JY6PpUvZhe2yB6gQl2jqTFp3U6fYjqA8Bk9MqlTLCglxsqX5eUbjf5I8ZPQVo0X-WnKqNL-VjFgmVJrnTNxORpRynrJC66PkXghrSqkUubqbHLGMSSGVHCW_Ln0b0UTbOgJLsC5EMllB06BbIvlu44rMEEKDgcyt7wJ5MZu_JNaRM1eDi2QGBr51fXWxI-DIbE5OLsZkDsZYh2RcbayzIaLHav8orpBcegzoDJK2JhfYRQ-N_WndkoxdtIu22t1P7tTQBHxwOI-Tz9O3nyan6fnHd2eT8XlqpNQx5RplVVCeQUVRcyMrCXWhTP8RsMhQaK1z1JIBVLWGTGT9TemqyIuea07FcfJ86Lv17X6FWG5sMNg04LDtQqmYFlxn_L-QKa2pzmQPn_4F123nXb9EybnQjDJ1Y6zxbQge63Lr7Qb8rmS03GdZDln28PGhW7fYYPWHHcLrwbMDgGCgqT04Y8MNp5koMt27J4Nru-2_hz0azDrE1l8rQanKCyb6ejrU92n-uK6DvypzJVRWnn75Wn54M5Un8_fTkovftVDHIg</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>Premenko-Lanier, Mary</creator><creator>Rota, Paul A.</creator><creator>Rhodes, Gary H.</creator><creator>Bellini, William J.</creator><creator>McChesney, Michael B.</creator><general>The University Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040601</creationdate><title>Protection against Challenge with Measles Virus (MV) in Infant Macaques by an MV DNA Vaccine Administered in the Presence of Neutralizing Antibody</title><author>Premenko-Lanier, Mary ; Rota, Paul A. ; Rhodes, Gary H. ; Bellini, William J. ; McChesney, Michael B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-29e4d8025ad0e92c4d4af87c207ab5e39996e941aadf9a5351aa79d8680e99203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adjuvants, Immunologic</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Antibodies</topic><topic>Antibodies, Viral - immunology</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>DNA</topic><topic>DNA vaccines</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunity</topic><topic>Immunoglobulin G - immunology</topic><topic>Infants</topic><topic>Infectious diseases</topic><topic>Interleukin-2 - immunology</topic><topic>Macaca mulatta</topic><topic>Male</topic><topic>Measles</topic><topic>Measles - immunology</topic><topic>Measles - prevention & control</topic><topic>Measles - virology</topic><topic>Measles Vaccine - immunology</topic><topic>Measles Vaccine - therapeutic use</topic><topic>Measles virus</topic><topic>Measles virus - genetics</topic><topic>Measles virus - immunology</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Neutralization Tests</topic><topic>Plasmids</topic><topic>Plasmids - immunology</topic><topic>T lymphocytes</topic><topic>Tetanus toxoid</topic><topic>Tetanus Toxoid - immunology</topic><topic>Vaccination</topic><topic>Vaccines, DNA - immunology</topic><topic>Vaccines, DNA - therapeutic use</topic><topic>Viremia - immunology</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Premenko-Lanier, Mary</creatorcontrib><creatorcontrib>Rota, Paul A.</creatorcontrib><creatorcontrib>Rhodes, Gary H.</creatorcontrib><creatorcontrib>Bellini, William J.</creatorcontrib><creatorcontrib>McChesney, Michael B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Premenko-Lanier, Mary</au><au>Rota, Paul A.</au><au>Rhodes, Gary H.</au><au>Bellini, William J.</au><au>McChesney, Michael B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protection against Challenge with Measles Virus (MV) in Infant Macaques by an MV DNA Vaccine Administered in the Presence of Neutralizing Antibody</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>189</volume><issue>11</issue><spage>2064</spage><epage>2071</epage><pages>2064-2071</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Measles virus (MV) infection is the major cause of vaccine-preventable death in infants and children worldwide. It is difficult to achieve immunity to MV infection by use of vaccines in infants during the first 6–9 months of life because of the presence of maternal antibody. Morbidity and mortality due to MV infection would decrease substantially if a vaccine administered at birth could prime immunity in the presence of maternal antibody.We demonstrate here that an MV DNA vaccine administered to infant macaques in the presence of maternal antibody primes MV-specific T cell responses but not de novo neutralizing antibody. This vaccine protected 80% of the infant macaques from skin rash and MV-induced immunosuppression. A molecular interleukin-2 adjuvant was required for protection with this vaccine. This macaque model shows that infants can be vaccinated against MV in the presence of maternal antibody. These results suggest that it is possible to develop an MV DNA vaccine that could protect infants in developing countries during the first months of life.</abstract><cop>Chicago, IL</cop><pub>The University Chicago Press</pub><pmid>15143474</pmid><doi>10.1086/420792</doi><tpages>8</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 2004-06, Vol.189 (11), p.2064-2071 |
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| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adjuvants, Immunologic Animals Animals, Newborn Antibodies Antibodies, Viral - immunology Biological and medical sciences Disease Models, Animal DNA DNA vaccines Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology Immunity Immunoglobulin G - immunology Infants Infectious diseases Interleukin-2 - immunology Macaca mulatta Male Measles Measles - immunology Measles - prevention & control Measles - virology Measles Vaccine - immunology Measles Vaccine - therapeutic use Measles virus Measles virus - genetics Measles virus - immunology Medical sciences Microbiology Miscellaneous Neutralization Tests Plasmids Plasmids - immunology T lymphocytes Tetanus toxoid Tetanus Toxoid - immunology Vaccination Vaccines, DNA - immunology Vaccines, DNA - therapeutic use Viremia - immunology Virology Viruses |
| title | Protection against Challenge with Measles Virus (MV) in Infant Macaques by an MV DNA Vaccine Administered in the Presence of Neutralizing Antibody |
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