Antiproliferative Constituents in Plants 9. Aerial Parts of Lippia dulcis and Lippia canescens
The antiproliferative constituents in the MeOH extracts of the aerial parts of Lippia dulcis TREV. and Lippia canescens KUNTH (Verbenaceae) were investigated. Activity-guided chemical investigation of the MeOH extracts resulted in the isolation of the three bisabolane-type sesquiterpenes [(+)-hernan...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2002, Vol.25(7), pp.920-922 |
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| creator | Abe, Fumiko Nagao, Tsuneatsu Okabe, Hikaru |
| description | The antiproliferative constituents in the MeOH extracts of the aerial parts of Lippia dulcis TREV. and Lippia canescens KUNTH (Verbenaceae) were investigated. Activity-guided chemical investigation of the MeOH extracts resulted in the isolation of the three bisabolane-type sesquiterpenes [(+)-hernandulcin (1), (−)-epihernandulcin (2), and (+)-anymol (3)] and four phenylethanoid glycosides [acteoside (4), isoacteoside (5), martynoside (6), and a new diacetylmartynoside (7)] from the former, and four phenylethanoid glycosides [acteoside (4), isoacteoside (5), arenarioside (8), and leucosceptoside A (9)] and three flavones [desmethoxycentaureidin (10), eupafolin (11), and 6-hydroxyluteolin (12)] from the latter. Antiproliferative activity of the isolated compounds against murine melanoma (B16F10), human gastric adenocarcinoma (MK-1), and human uterine carcinoma (HeLa) cells was estimated. (+)-Anymol (3), acteoside (4), isoacteoside (5), arenarioside (8), eupafolin (11), and 6-hydroxyluteolin (12) had GI50 values of 10—16 μM against B16F10 cell. Desmethoxycentaureidin (10) and eupafolin (11) showed high inhibitory activity against HeLa cell growth (GI50 9 μM, and 6 μM, respectively). |
| doi_str_mv | 10.1248/bpb.25.920 |
| format | Article |
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Aerial Parts of Lippia dulcis and Lippia canescens</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Abe, Fumiko ; Nagao, Tsuneatsu ; Okabe, Hikaru</creator><creatorcontrib>Abe, Fumiko ; Nagao, Tsuneatsu ; Okabe, Hikaru</creatorcontrib><description>The antiproliferative constituents in the MeOH extracts of the aerial parts of Lippia dulcis TREV. and Lippia canescens KUNTH (Verbenaceae) were investigated. Activity-guided chemical investigation of the MeOH extracts resulted in the isolation of the three bisabolane-type sesquiterpenes [(+)-hernandulcin (1), (−)-epihernandulcin (2), and (+)-anymol (3)] and four phenylethanoid glycosides [acteoside (4), isoacteoside (5), martynoside (6), and a new diacetylmartynoside (7)] from the former, and four phenylethanoid glycosides [acteoside (4), isoacteoside (5), arenarioside (8), and leucosceptoside A (9)] and three flavones [desmethoxycentaureidin (10), eupafolin (11), and 6-hydroxyluteolin (12)] from the latter. Antiproliferative activity of the isolated compounds against murine melanoma (B16F10), human gastric adenocarcinoma (MK-1), and human uterine carcinoma (HeLa) cells was estimated. (+)-Anymol (3), acteoside (4), isoacteoside (5), arenarioside (8), eupafolin (11), and 6-hydroxyluteolin (12) had GI50 values of 10—16 μM against B16F10 cell. Desmethoxycentaureidin (10) and eupafolin (11) showed high inhibitory activity against HeLa cell growth (GI50 9 μM, and 6 μM, respectively).</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.25.920</identifier><identifier>PMID: 12132670</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; antiproliferative activity ; Biological and medical sciences ; Cell Division - drug effects ; Drug Screening Assays, Antitumor ; flavone ; Flavonoids - isolation & purification ; Flavonoids - pharmacology ; General pharmacology ; Glycosides - isolation & purification ; Glycosides - pharmacology ; Humans ; Lippia - chemistry ; Lippia canescens ; Lippia dulcis ; Medical sciences ; Mice ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phenylethanoid glycoside ; Plant Components, Aerial - chemistry ; sesquiterpene ; Sesquiterpenes - isolation & purification ; Sesquiterpenes - pharmacology ; Tumor Cells, Cultured</subject><ispartof>Biological and Pharmaceutical Bulletin, 2002, Vol.25(7), pp.920-922</ispartof><rights>2002 The Pharmaceutical Society of Japan</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c625t-acc6fb4d02e13376535c0e9a2cf023868522c071fddcc27349a482efa5cb4dd43</citedby><cites>FETCH-LOGICAL-c625t-acc6fb4d02e13376535c0e9a2cf023868522c071fddcc27349a482efa5cb4dd43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13834815$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12132670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abe, Fumiko</creatorcontrib><creatorcontrib>Nagao, Tsuneatsu</creatorcontrib><creatorcontrib>Okabe, Hikaru</creatorcontrib><title>Antiproliferative Constituents in Plants 9. Aerial Parts of Lippia dulcis and Lippia canescens</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The antiproliferative constituents in the MeOH extracts of the aerial parts of Lippia dulcis TREV. and Lippia canescens KUNTH (Verbenaceae) were investigated. Activity-guided chemical investigation of the MeOH extracts resulted in the isolation of the three bisabolane-type sesquiterpenes [(+)-hernandulcin (1), (−)-epihernandulcin (2), and (+)-anymol (3)] and four phenylethanoid glycosides [acteoside (4), isoacteoside (5), martynoside (6), and a new diacetylmartynoside (7)] from the former, and four phenylethanoid glycosides [acteoside (4), isoacteoside (5), arenarioside (8), and leucosceptoside A (9)] and three flavones [desmethoxycentaureidin (10), eupafolin (11), and 6-hydroxyluteolin (12)] from the latter. Antiproliferative activity of the isolated compounds against murine melanoma (B16F10), human gastric adenocarcinoma (MK-1), and human uterine carcinoma (HeLa) cells was estimated. (+)-Anymol (3), acteoside (4), isoacteoside (5), arenarioside (8), eupafolin (11), and 6-hydroxyluteolin (12) had GI50 values of 10—16 μM against B16F10 cell. Desmethoxycentaureidin (10) and eupafolin (11) showed high inhibitory activity against HeLa cell growth (GI50 9 μM, and 6 μM, respectively).</description><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>antiproliferative activity</subject><subject>Biological and medical sciences</subject><subject>Cell Division - drug effects</subject><subject>Drug Screening Assays, Antitumor</subject><subject>flavone</subject><subject>Flavonoids - isolation & purification</subject><subject>Flavonoids - pharmacology</subject><subject>General pharmacology</subject><subject>Glycosides - isolation & purification</subject><subject>Glycosides - pharmacology</subject><subject>Humans</subject><subject>Lippia - chemistry</subject><subject>Lippia canescens</subject><subject>Lippia dulcis</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phenylethanoid glycoside</subject><subject>Plant Components, Aerial - chemistry</subject><subject>sesquiterpene</subject><subject>Sesquiterpenes - isolation & purification</subject><subject>Sesquiterpenes - pharmacology</subject><subject>Tumor Cells, Cultured</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtr3DAURkVoaSZpN_kBxVCSRcBTvWWvwjA0aWGgWbTbijuy1GrwyK5kB_rve8NMEshGz6N7Px1CLhhdMi6bz9txu-Rq2XJ6QhZMSFMrztQbsqAta2rNVHNKzkrZUUoN5eIdOWWcCa4NXZBfqzTFMQ99DD7DFB98tR5SmeI0-zSVKqbqvofHVbusVj5H6Kt7yLgfQrWJ4xih6ubexVJB6p5OHCRfnE_lPXkboC_-w3E-Jz9vv_xYf6033---rVeb2mmuphqc02ErO8o9E8JoJZSjvgXuAgZudKM4d9Sw0HXOcSNkC7LhPoBy-KqT4pxcHeriV_7Ovkx2HzFAj9H9MBdrWCu40hzBT6_A3TDnhNksk7JlrdFGI3V9oFweSsk-2DHHPeR_llH76Nyic8uVRecIfzyWnLd7372gR8kIXB4BKA76kCGhrxdONEI2TCF3c-B2ZYLf_hlA3dH1_qmnOQzY-vnG_YFsfRL_AfdDn9c</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>Abe, Fumiko</creator><creator>Nagao, Tsuneatsu</creator><creator>Okabe, Hikaru</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20020701</creationdate><title>Antiproliferative Constituents in Plants 9. Aerial Parts of Lippia dulcis and Lippia canescens</title><author>Abe, Fumiko ; Nagao, Tsuneatsu ; Okabe, Hikaru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c625t-acc6fb4d02e13376535c0e9a2cf023868522c071fddcc27349a482efa5cb4dd43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>antiproliferative activity</topic><topic>Biological and medical sciences</topic><topic>Cell Division - drug effects</topic><topic>Drug Screening Assays, Antitumor</topic><topic>flavone</topic><topic>Flavonoids - isolation & purification</topic><topic>Flavonoids - pharmacology</topic><topic>General pharmacology</topic><topic>Glycosides - isolation & purification</topic><topic>Glycosides - pharmacology</topic><topic>Humans</topic><topic>Lippia - chemistry</topic><topic>Lippia canescens</topic><topic>Lippia dulcis</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phenylethanoid glycoside</topic><topic>Plant Components, Aerial - chemistry</topic><topic>sesquiterpene</topic><topic>Sesquiterpenes - isolation & purification</topic><topic>Sesquiterpenes - pharmacology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abe, Fumiko</creatorcontrib><creatorcontrib>Nagao, Tsuneatsu</creatorcontrib><creatorcontrib>Okabe, Hikaru</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abe, Fumiko</au><au>Nagao, Tsuneatsu</au><au>Okabe, Hikaru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiproliferative Constituents in Plants 9. Aerial Parts of Lippia dulcis and Lippia canescens</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>25</volume><issue>7</issue><spage>920</spage><epage>922</epage><pages>920-922</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>The antiproliferative constituents in the MeOH extracts of the aerial parts of Lippia dulcis TREV. and Lippia canescens KUNTH (Verbenaceae) were investigated. Activity-guided chemical investigation of the MeOH extracts resulted in the isolation of the three bisabolane-type sesquiterpenes [(+)-hernandulcin (1), (−)-epihernandulcin (2), and (+)-anymol (3)] and four phenylethanoid glycosides [acteoside (4), isoacteoside (5), martynoside (6), and a new diacetylmartynoside (7)] from the former, and four phenylethanoid glycosides [acteoside (4), isoacteoside (5), arenarioside (8), and leucosceptoside A (9)] and three flavones [desmethoxycentaureidin (10), eupafolin (11), and 6-hydroxyluteolin (12)] from the latter. Antiproliferative activity of the isolated compounds against murine melanoma (B16F10), human gastric adenocarcinoma (MK-1), and human uterine carcinoma (HeLa) cells was estimated. (+)-Anymol (3), acteoside (4), isoacteoside (5), arenarioside (8), eupafolin (11), and 6-hydroxyluteolin (12) had GI50 values of 10—16 μM against B16F10 cell. Desmethoxycentaureidin (10) and eupafolin (11) showed high inhibitory activity against HeLa cell growth (GI50 9 μM, and 6 μM, respectively).</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>12132670</pmid><doi>10.1248/bpb.25.920</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology antiproliferative activity Biological and medical sciences Cell Division - drug effects Drug Screening Assays, Antitumor flavone Flavonoids - isolation & purification Flavonoids - pharmacology General pharmacology Glycosides - isolation & purification Glycosides - pharmacology Humans Lippia - chemistry Lippia canescens Lippia dulcis Medical sciences Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phenylethanoid glycoside Plant Components, Aerial - chemistry sesquiterpene Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Tumor Cells, Cultured |
| title | Antiproliferative Constituents in Plants 9. Aerial Parts of Lippia dulcis and Lippia canescens |
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