Characterization of the basic fibroblast growth factor-evoked proliferation of the human Müller cell line, MIO-M1

Basic fibroblast growth factor (bFGF) has been suggested to mediate activation of Müller glial cells in the ischemic-hypoxic retina. However, the intracellular pathways activated by bFGF in human Müller cells have been little explored. We characterized the signaling transduction pathways which are i...

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Veröffentlicht in:	Graefe's archive for clinical and experimental ophthalmology 2004-05, Vol.242 (5), p.414-422
Hauptverfasser:	Hollborn, Margrit, Jahn, Karsten, Limb, G Astrid, Kohen, Leon, Wiedemann, Peter, Bringmann, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Bromodeoxyuridine - metabolism Cell Division - drug effects Cell Line DNA Replication Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Enzyme-Linked Immunosorbent Assay Fibroblast Growth Factor 2 - pharmacology Hepatocyte Growth Factor - metabolism Humans Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Neuroglia - cytology Neuroglia - metabolism Ophthalmology p38 Mitogen-Activated Protein Kinases Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Retina - cytology Retina - metabolism Signal Transduction - physiology Vascular Endothelial Growth Factor A - metabolism
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