Single fraction radiotherapy is efficacious: a further analysis of the Dutch Bone Metastasis Study controlling for the influence of retreatment
The Dutch Bone Metastasis Study on the effect on painful bone metastases of 8 Gy single fraction (SF) vs. 24 Gy in multiple fractions (MF) showed 24% retreatment after SF vs. 6% after MF ( p < 0.001). The purpose of the present study was to evaluate factors influencing retreatment and its effect...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2004-06, Vol.59 (2), p.528-537 |
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| container_title | International journal of radiation oncology, biology, physics |
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| creator | van der Linden, Yvette M Lok, Judith J Steenland, Elsbeth Martijn, Hendrik van Houwelingen, Hans Marijnen, Corrie A.M Leer, Jan Willem H |
| description | The Dutch Bone Metastasis Study on the effect on painful bone metastases of 8 Gy single fraction (SF) vs. 24 Gy in multiple fractions (MF) showed 24% retreatment after SF vs. 6% after MF (
p < 0.001). The purpose of the present study was to evaluate factors influencing retreatment and its effect on response.
The database on all randomized patients was reanalyzed with separately calculated responses to initial treatment and retreatment.
Response to initial treatment was 71% after SF vs. 73% after MF (
p = 0.84). Retreatment raised response to 75% for SF; MF remained unaltered (
p = 0.54). The response status after initial treatment did not predict occurrence of retreatment: 35% SF vs. 8% MF nonresponders and 22% SF vs. 10% MF patients with progressive pain were retreated. Logistic regression analyses showed the randomization arm and the pain score before retreatment to significantly predict retreatment (
p < 0.001). Retreatment for nonresponders was successful in 66% SF vs. 33% MF patients (
p = 0.13). Retreatment for progression was successful in 70% SF vs. 57% MF patients (
p = 0.24).
With or without the effect of retreatment, SF and MF radiotherapy provided equal palliation for painful bone metastases. Irrespective of response to initial treatment, physicians were more willing to retreat after a single fraction. Overall, retreatment was effective in 63% of retreated patients. |
| doi_str_mv | 10.1016/j.ijrobp.2003.10.006 |
| format | Article |
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p < 0.001). The purpose of the present study was to evaluate factors influencing retreatment and its effect on response.
The database on all randomized patients was reanalyzed with separately calculated responses to initial treatment and retreatment.
Response to initial treatment was 71% after SF vs. 73% after MF (
p = 0.84). Retreatment raised response to 75% for SF; MF remained unaltered (
p = 0.54). The response status after initial treatment did not predict occurrence of retreatment: 35% SF vs. 8% MF nonresponders and 22% SF vs. 10% MF patients with progressive pain were retreated. Logistic regression analyses showed the randomization arm and the pain score before retreatment to significantly predict retreatment (
p < 0.001). Retreatment for nonresponders was successful in 66% SF vs. 33% MF patients (
p = 0.13). Retreatment for progression was successful in 70% SF vs. 57% MF patients (
p = 0.24).
With or without the effect of retreatment, SF and MF radiotherapy provided equal palliation for painful bone metastases. Irrespective of response to initial treatment, physicians were more willing to retreat after a single fraction. Overall, retreatment was effective in 63% of retreated patients.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2003.10.006</identifier><identifier>PMID: 15145173</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analgesics - therapeutic use ; Biological and medical sciences ; Bone metastases ; Bone Neoplasms - radiotherapy ; Bone Neoplasms - secondary ; Disease Progression ; Female ; Humans ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Netherlands ; Pain ; Pain - drug therapy ; Pain - etiology ; Pain - radiotherapy ; Pain Measurement ; Proportional Hazards Models ; Radiotherapy ; Radiotherapy Dosage ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Response ; Retreatment ; Technology. Biomaterials. Equipments. Material. Instrumentation ; Time Factors ; Treatment Outcome</subject><ispartof>International journal of radiation oncology, biology, physics, 2004-06, Vol.59 (2), p.528-537</ispartof><rights>2004 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-f11984c3e1d90e4f8962a44b09a98f1063ed7d32fcb496a993a9bd5fb463d59a3</citedby><cites>FETCH-LOGICAL-c531t-f11984c3e1d90e4f8962a44b09a98f1063ed7d32fcb496a993a9bd5fb463d59a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijrobp.2003.10.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15744076$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15145173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van der Linden, Yvette M</creatorcontrib><creatorcontrib>Lok, Judith J</creatorcontrib><creatorcontrib>Steenland, Elsbeth</creatorcontrib><creatorcontrib>Martijn, Hendrik</creatorcontrib><creatorcontrib>van Houwelingen, Hans</creatorcontrib><creatorcontrib>Marijnen, Corrie A.M</creatorcontrib><creatorcontrib>Leer, Jan Willem H</creatorcontrib><creatorcontrib>Dutch Bone Metastasis Study Group</creatorcontrib><title>Single fraction radiotherapy is efficacious: a further analysis of the Dutch Bone Metastasis Study controlling for the influence of retreatment</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>The Dutch Bone Metastasis Study on the effect on painful bone metastases of 8 Gy single fraction (SF) vs. 24 Gy in multiple fractions (MF) showed 24% retreatment after SF vs. 6% after MF (
p < 0.001). The purpose of the present study was to evaluate factors influencing retreatment and its effect on response.
The database on all randomized patients was reanalyzed with separately calculated responses to initial treatment and retreatment.
Response to initial treatment was 71% after SF vs. 73% after MF (
p = 0.84). Retreatment raised response to 75% for SF; MF remained unaltered (
p = 0.54). The response status after initial treatment did not predict occurrence of retreatment: 35% SF vs. 8% MF nonresponders and 22% SF vs. 10% MF patients with progressive pain were retreated. Logistic regression analyses showed the randomization arm and the pain score before retreatment to significantly predict retreatment (
p < 0.001). Retreatment for nonresponders was successful in 66% SF vs. 33% MF patients (
p = 0.13). Retreatment for progression was successful in 70% SF vs. 57% MF patients (
p = 0.24).
With or without the effect of retreatment, SF and MF radiotherapy provided equal palliation for painful bone metastases. Irrespective of response to initial treatment, physicians were more willing to retreat after a single fraction. Overall, retreatment was effective in 63% of retreated patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analgesics - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bone metastases</subject><subject>Bone Neoplasms - radiotherapy</subject><subject>Bone Neoplasms - secondary</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Netherlands</subject><subject>Pain</subject><subject>Pain - drug therapy</subject><subject>Pain - etiology</subject><subject>Pain - radiotherapy</subject><subject>Pain Measurement</subject><subject>Proportional Hazards Models</subject><subject>Radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Response</subject><subject>Retreatment</subject><subject>Technology. Biomaterials. Equipments. Material. Instrumentation</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-KFDEQxoMo7rj6BiK56K3HpJPunngQdNd_sOJhFbyF6qTiZuhJZpO0ME-xr2zaGdCTQiBQ9auvku8j5Clna854_3K79tsUx_26ZUzU0pqx_h5Z8c2gGtF13--TFRM9a0SFz8ijnLeMMc4H-ZCc8Y7Ljg9iRe6uffgxIXUJTPEx0ATWx3KDCfYH6jNF57wB4-OcX1Ggbk5Lk0KA6ZBrPzpaC_RyLuaGvo0B6WcskOupzesy2wM1MZQUp6luoi6m37wPbpoxGFwEEpaEUHYYymPywMGU8cnpPiff3r_7evGxufry4dPFm6vGdIKXxnGuNtII5FYxlG6j-hakHJkCtXGc9QLtYEXrzChVD0oJUKPt3Ch7YTsF4py8OOruU7ydMRe989ngNEHA-lU9cCXaatN_Qa5k9bJlFZRH0KSYc0Kn98nvIB00Z3pJTG_1MTG9JLZUa2J17NlJfx53aP8MnSKqwPMTANnAVIMKxue_uEFKNixCr48cVtt-ekw6G784bH1CU7SN_t8v-QVAvrji</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>van der Linden, Yvette M</creator><creator>Lok, Judith J</creator><creator>Steenland, Elsbeth</creator><creator>Martijn, Hendrik</creator><creator>van Houwelingen, Hans</creator><creator>Marijnen, Corrie A.M</creator><creator>Leer, Jan Willem H</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20040601</creationdate><title>Single fraction radiotherapy is efficacious: a further analysis of the Dutch Bone Metastasis Study controlling for the influence of retreatment</title><author>van der Linden, Yvette M ; Lok, Judith J ; Steenland, Elsbeth ; Martijn, Hendrik ; van Houwelingen, Hans ; Marijnen, Corrie A.M ; Leer, Jan Willem H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-f11984c3e1d90e4f8962a44b09a98f1063ed7d32fcb496a993a9bd5fb463d59a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analgesics - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Bone metastases</topic><topic>Bone Neoplasms - radiotherapy</topic><topic>Bone Neoplasms - secondary</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Netherlands</topic><topic>Pain</topic><topic>Pain - drug therapy</topic><topic>Pain - etiology</topic><topic>Pain - radiotherapy</topic><topic>Pain Measurement</topic><topic>Proportional Hazards Models</topic><topic>Radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Response</topic><topic>Retreatment</topic><topic>Technology. Biomaterials. Equipments. Material. Instrumentation</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van der Linden, Yvette M</creatorcontrib><creatorcontrib>Lok, Judith J</creatorcontrib><creatorcontrib>Steenland, Elsbeth</creatorcontrib><creatorcontrib>Martijn, Hendrik</creatorcontrib><creatorcontrib>van Houwelingen, Hans</creatorcontrib><creatorcontrib>Marijnen, Corrie A.M</creatorcontrib><creatorcontrib>Leer, Jan Willem H</creatorcontrib><creatorcontrib>Dutch Bone Metastasis Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van der Linden, Yvette M</au><au>Lok, Judith J</au><au>Steenland, Elsbeth</au><au>Martijn, Hendrik</au><au>van Houwelingen, Hans</au><au>Marijnen, Corrie A.M</au><au>Leer, Jan Willem H</au><aucorp>Dutch Bone Metastasis Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single fraction radiotherapy is efficacious: a further analysis of the Dutch Bone Metastasis Study controlling for the influence of retreatment</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>59</volume><issue>2</issue><spage>528</spage><epage>537</epage><pages>528-537</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>The Dutch Bone Metastasis Study on the effect on painful bone metastases of 8 Gy single fraction (SF) vs. 24 Gy in multiple fractions (MF) showed 24% retreatment after SF vs. 6% after MF (
p < 0.001). The purpose of the present study was to evaluate factors influencing retreatment and its effect on response.
The database on all randomized patients was reanalyzed with separately calculated responses to initial treatment and retreatment.
Response to initial treatment was 71% after SF vs. 73% after MF (
p = 0.84). Retreatment raised response to 75% for SF; MF remained unaltered (
p = 0.54). The response status after initial treatment did not predict occurrence of retreatment: 35% SF vs. 8% MF nonresponders and 22% SF vs. 10% MF patients with progressive pain were retreated. Logistic regression analyses showed the randomization arm and the pain score before retreatment to significantly predict retreatment (
p < 0.001). Retreatment for nonresponders was successful in 66% SF vs. 33% MF patients (
p = 0.13). Retreatment for progression was successful in 70% SF vs. 57% MF patients (
p = 0.24).
With or without the effect of retreatment, SF and MF radiotherapy provided equal palliation for painful bone metastases. Irrespective of response to initial treatment, physicians were more willing to retreat after a single fraction. Overall, retreatment was effective in 63% of retreated patients.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15145173</pmid><doi>10.1016/j.ijrobp.2003.10.006</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0360-3016 |
| ispartof | International journal of radiation oncology, biology, physics, 2004-06, Vol.59 (2), p.528-537 |
| issn | 0360-3016 1879-355X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Aged, 80 and over Analgesics - therapeutic use Biological and medical sciences Bone metastases Bone Neoplasms - radiotherapy Bone Neoplasms - secondary Disease Progression Female Humans Logistic Models Male Medical sciences Middle Aged Netherlands Pain Pain - drug therapy Pain - etiology Pain - radiotherapy Pain Measurement Proportional Hazards Models Radiotherapy Radiotherapy Dosage Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Response Retreatment Technology. Biomaterials. Equipments. Material. Instrumentation Time Factors Treatment Outcome |
| title | Single fraction radiotherapy is efficacious: a further analysis of the Dutch Bone Metastasis Study controlling for the influence of retreatment |
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