Epithelioid hemangioendothelioma of the liver disseminated to the peritoneum treated with liver transplantation and interferon alpha-2B
Epithelioid hemangioendothelioma (EH) is a rare, low-grade, malignant neoplasm of vascular origin that may develop at different sites, such as in the soft tissue, lungs, or liver. We report the case of a 21-year-old female with primary EH of the liver treated by liver transplantation and review the...
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| Veröffentlicht in: | Transplantation 2002-07, Vol.74 (1), p.128-130 |
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| creator | KAYLER, Liise K MERION, Robert M ARENAS, Juan D MAGEE, John C CAMPBELL, Darrell A RUDICH, Steven M PUNCH, Jeffrey D |
| description | Epithelioid hemangioendothelioma (EH) is a rare, low-grade, malignant neoplasm of vascular origin that may develop at different sites, such as in the soft tissue, lungs, or liver. We report the case of a 21-year-old female with primary EH of the liver treated by liver transplantation and review the available literature on EH. This patient developed symptomatic recurrence of the tumor in the pelvis 2 months posttransplant. Treatment with interferon alpha-2b resulted in substantial regression of the pelvic metastases and alleviation of symptoms, but the patient developed graft rejection and died of associated complications 16 months posttransplant. This report is the first showing the efficacy of interferon in this setting. |
| doi_str_mv | 10.1097/00007890-200207150-00022 |
| format | Article |
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We report the case of a 21-year-old female with primary EH of the liver treated by liver transplantation and review the available literature on EH. This patient developed symptomatic recurrence of the tumor in the pelvis 2 months posttransplant. Treatment with interferon alpha-2b resulted in substantial regression of the pelvic metastases and alleviation of symptoms, but the patient developed graft rejection and died of associated complications 16 months posttransplant. This report is the first showing the efficacy of interferon in this setting.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-200207150-00022</identifier><identifier>PMID: 12134111</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adult ; Antineoplastic Agents - administration & dosage ; Biological and medical sciences ; Female ; Hemangioendothelioma, Epithelioid - drug therapy ; Hemangioendothelioma, Epithelioid - secondary ; Hemangioendothelioma, Epithelioid - surgery ; Humans ; Interferon alpha-2 ; Interferon-alpha - administration & dosage ; Liver Neoplasms - drug therapy ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Liver Transplantation ; Liver, biliary tract, pancreas, portal circulation, spleen ; Medical sciences ; Peritoneal Neoplasms - drug therapy ; Peritoneal Neoplasms - secondary ; Peritoneal Neoplasms - surgery ; Recombinant Proteins ; Surgery (general aspects). 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Graft diseases ; Surgery of the digestive system</subject><ispartof>Transplantation, 2002-07, Vol.74 (1), p.128-130</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-55195c39946f4bb0b675362129e81fd45dcb35bf5751925541ffa4d41501a61e3</citedby><cites>FETCH-LOGICAL-c422t-55195c39946f4bb0b675362129e81fd45dcb35bf5751925541ffa4d41501a61e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13815257$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12134111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAYLER, Liise K</creatorcontrib><creatorcontrib>MERION, Robert M</creatorcontrib><creatorcontrib>ARENAS, Juan D</creatorcontrib><creatorcontrib>MAGEE, John C</creatorcontrib><creatorcontrib>CAMPBELL, Darrell A</creatorcontrib><creatorcontrib>RUDICH, Steven M</creatorcontrib><creatorcontrib>PUNCH, Jeffrey D</creatorcontrib><title>Epithelioid hemangioendothelioma of the liver disseminated to the peritoneum treated with liver transplantation and interferon alpha-2B</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Epithelioid hemangioendothelioma (EH) is a rare, low-grade, malignant neoplasm of vascular origin that may develop at different sites, such as in the soft tissue, lungs, or liver. We report the case of a 21-year-old female with primary EH of the liver treated by liver transplantation and review the available literature on EH. This patient developed symptomatic recurrence of the tumor in the pelvis 2 months posttransplant. Treatment with interferon alpha-2b resulted in substantial regression of the pelvic metastases and alleviation of symptoms, but the patient developed graft rejection and died of associated complications 16 months posttransplant. This report is the first showing the efficacy of interferon in this setting.</description><subject>Adult</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Hemangioendothelioma, Epithelioid - drug therapy</subject><subject>Hemangioendothelioma, Epithelioid - secondary</subject><subject>Hemangioendothelioma, Epithelioid - surgery</subject><subject>Humans</subject><subject>Interferon alpha-2</subject><subject>Interferon-alpha - administration & dosage</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver Transplantation</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Medical sciences</subject><subject>Peritoneal Neoplasms - drug therapy</subject><subject>Peritoneal Neoplasms - secondary</subject><subject>Peritoneal Neoplasms - surgery</subject><subject>Recombinant Proteins</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi1ERbeFV0C-wC3g8Z84PkLVlkqVuJRz5MRj1iiJg-0F8QS8Nu5uoEd8GXvm941H8xFCgb0DZvR7Vo_uDGs4Y5xpUKypGc6fkR0oIZuWdew52TEmoQEh9Dm5yPlbRZTQ-gU5Bw5CAsCO_L5eQ9njFGJwdI-zXb6GiIuLp-RsafS03ukUfmCiLuSMc1hsQUdLPFZWTKHEBQ8zLQmPlZ-156YoyS55nexSbAlxoXZxNCwFk8f0-JzWvW34x5fkzNsp46stXpIvN9cPV5-a-8-3d1cf7ptRcl4apcCoURgjWy-HgQ2tVqLlwA124J1UbhyEGrzSFeRKSfDeSifrhsC2gOKSvD31XVP8fsBc-jnkEac6IMZD7jUYAVrw_4LQtQLAmAp2J3BMMeeEvl9TmG361QPrH93q_7rV_3OrP7pVpa-3Pw7DjO5JuNlTgTcbYPNoJ193OYb8xIkOFFda_AFJap5m</recordid><startdate>20020715</startdate><enddate>20020715</enddate><creator>KAYLER, Liise K</creator><creator>MERION, Robert M</creator><creator>ARENAS, Juan D</creator><creator>MAGEE, John C</creator><creator>CAMPBELL, Darrell A</creator><creator>RUDICH, Steven M</creator><creator>PUNCH, Jeffrey D</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020715</creationdate><title>Epithelioid hemangioendothelioma of the liver disseminated to the peritoneum treated with liver transplantation and interferon alpha-2B</title><author>KAYLER, Liise K ; MERION, Robert M ; ARENAS, Juan D ; MAGEE, John C ; CAMPBELL, Darrell A ; RUDICH, Steven M ; PUNCH, Jeffrey D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-55195c39946f4bb0b675362129e81fd45dcb35bf5751925541ffa4d41501a61e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Hemangioendothelioma, Epithelioid - drug therapy</topic><topic>Hemangioendothelioma, Epithelioid - secondary</topic><topic>Hemangioendothelioma, Epithelioid - surgery</topic><topic>Humans</topic><topic>Interferon alpha-2</topic><topic>Interferon-alpha - administration & dosage</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Liver Transplantation</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>Medical sciences</topic><topic>Peritoneal Neoplasms - drug therapy</topic><topic>Peritoneal Neoplasms - secondary</topic><topic>Peritoneal Neoplasms - surgery</topic><topic>Recombinant Proteins</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAYLER, Liise K</creatorcontrib><creatorcontrib>MERION, Robert M</creatorcontrib><creatorcontrib>ARENAS, Juan D</creatorcontrib><creatorcontrib>MAGEE, John C</creatorcontrib><creatorcontrib>CAMPBELL, Darrell A</creatorcontrib><creatorcontrib>RUDICH, Steven M</creatorcontrib><creatorcontrib>PUNCH, Jeffrey D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAYLER, Liise K</au><au>MERION, Robert M</au><au>ARENAS, Juan D</au><au>MAGEE, John C</au><au>CAMPBELL, Darrell A</au><au>RUDICH, Steven M</au><au>PUNCH, Jeffrey D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epithelioid hemangioendothelioma of the liver disseminated to the peritoneum treated with liver transplantation and interferon alpha-2B</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2002-07-15</date><risdate>2002</risdate><volume>74</volume><issue>1</issue><spage>128</spage><epage>130</epage><pages>128-130</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Epithelioid hemangioendothelioma (EH) is a rare, low-grade, malignant neoplasm of vascular origin that may develop at different sites, such as in the soft tissue, lungs, or liver. We report the case of a 21-year-old female with primary EH of the liver treated by liver transplantation and review the available literature on EH. This patient developed symptomatic recurrence of the tumor in the pelvis 2 months posttransplant. Treatment with interferon alpha-2b resulted in substantial regression of the pelvic metastases and alleviation of symptoms, but the patient developed graft rejection and died of associated complications 16 months posttransplant. This report is the first showing the efficacy of interferon in this setting.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>12134111</pmid><doi>10.1097/00007890-200207150-00022</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Antineoplastic Agents - administration & dosage Biological and medical sciences Female Hemangioendothelioma, Epithelioid - drug therapy Hemangioendothelioma, Epithelioid - secondary Hemangioendothelioma, Epithelioid - surgery Humans Interferon alpha-2 Interferon-alpha - administration & dosage Liver Neoplasms - drug therapy Liver Neoplasms - pathology Liver Neoplasms - surgery Liver Transplantation Liver, biliary tract, pancreas, portal circulation, spleen Medical sciences Peritoneal Neoplasms - drug therapy Peritoneal Neoplasms - secondary Peritoneal Neoplasms - surgery Recombinant Proteins Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system |
| title | Epithelioid hemangioendothelioma of the liver disseminated to the peritoneum treated with liver transplantation and interferon alpha-2B |
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