Coronary collateralization: determinants of adequate distal vessel filling after arterial occlusion
BACKGROUNDThe protective effect of collateral vessels in coronary artery disease (CAD) is well established. Little is known, however, about factors that influence collateral formation. METHODSWe studied the coronary angiograms of 200 consecutive patients with single-vessel coronary artery occlusion....
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| Veröffentlicht in: | Coronary artery disease 2002-05, Vol.13 (3), p.155-159 |
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| creator | Kilian, Jens G Keech, Anthony Adams, Mark R Celermajer, David S |
| description | BACKGROUNDThe protective effect of collateral vessels in coronary artery disease (CAD) is well established. Little is known, however, about factors that influence collateral formation.
METHODSWe studied the coronary angiograms of 200 consecutive patients with single-vessel coronary artery occlusion. Patients were excluded if obstructive stenoses were present in other vessels or if prior revascularization had been undertaken. Collateral circulation to the occluded artery was graded as ‘poor’ (no or incomplete filling) or ‘rich’ (complete filling). Patient characteristics, including mode of presentation, medications and CAD risk factors, were assessed.
RESULTSPositive univariate correlates of rich collaterals included increasing age [odds ratio (OR) 1.03, P = 0.016], ‘statin’ use (OR 2.50, P = 0.005), nitrate use (OR 1.96, P = 0.034), calcium-channel blocker (CCB) use (OR 4.07, P |
| doi_str_mv | 10.1097/00019501-200205000-00004 |
| format | Article |
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METHODSWe studied the coronary angiograms of 200 consecutive patients with single-vessel coronary artery occlusion. Patients were excluded if obstructive stenoses were present in other vessels or if prior revascularization had been undertaken. Collateral circulation to the occluded artery was graded as ‘poor’ (no or incomplete filling) or ‘rich’ (complete filling). Patient characteristics, including mode of presentation, medications and CAD risk factors, were assessed.
RESULTSPositive univariate correlates of rich collaterals included increasing age [odds ratio (OR) 1.03, P = 0.016], ‘statin’ use (OR 2.50, P = 0.005), nitrate use (OR 1.96, P = 0.034), calcium-channel blocker (CCB) use (OR 4.07, P < 0.001), presentation with stable angina (OR 2.34, P = 0.006), longer time since diagnosis of CAD (OR 1.12, P = 0.002) and history of hyperlipidemia (OR 3.55, P < 0.001). Significantly poorer collateralization was observed in the setting of acute myocardial infarction (MI) (OR 0.23, P < 0.001), diabetes mellitus (OR 0.33, P = 0.003), impaired left ventricular function (OR 0.64, P = 0.015) and occlusion of the left anterior descending coronary artery (LAD) (OR 0.28, P < 0.001). On multivariate analysis, rich collateralization was associated with hyperlipidemia (P = 0.003) and CCB use (P = 0.028). Independent predictors of poor collaterals were presence of diabetes (P < 0.001), LAD occlusion (P = 0.001) and presentation with acute MI (P = 0.017).
CONCLUSIONDiabetes mellitus, occlusion of the LAD and presentation with acute MI are independently associated with poor distal vessel collateralization, whereas hyperlipidemia and use of CCBs are associated with rich collateralization. Factors determining coronary collateral formation may in turn influence outcomes after coronary artery occlusion.</description><identifier>ISSN: 0954-6928</identifier><identifier>EISSN: 1473-5830</identifier><identifier>DOI: 10.1097/00019501-200205000-00004</identifier><identifier>PMID: 12131019</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins, Inc</publisher><subject>Australia - epidemiology ; Collateral Circulation - physiology ; Coronary Artery Disease - complications ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - physiopathology ; Coronary Disease - complications ; Coronary Disease - epidemiology ; Coronary Disease - physiopathology ; Coronary Vessels - physiology ; Female ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Myocardial Infarction - complications ; Myocardial Infarction - epidemiology ; Myocardial Infarction - physiopathology ; Risk Factors ; Statistics as Topic ; Ventricular Function, Left - physiology</subject><ispartof>Coronary artery disease, 2002-05, Vol.13 (3), p.155-159</ispartof><rights>2002 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3564-b26eca2d2bf327589da0f1e54e98cb74901a02c638fca6886c9b3b91424107613</citedby><cites>FETCH-LOGICAL-c3564-b26eca2d2bf327589da0f1e54e98cb74901a02c638fca6886c9b3b91424107613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12131019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kilian, Jens G</creatorcontrib><creatorcontrib>Keech, Anthony</creatorcontrib><creatorcontrib>Adams, Mark R</creatorcontrib><creatorcontrib>Celermajer, David S</creatorcontrib><title>Coronary collateralization: determinants of adequate distal vessel filling after arterial occlusion</title><title>Coronary artery disease</title><addtitle>Coron Artery Dis</addtitle><description>BACKGROUNDThe protective effect of collateral vessels in coronary artery disease (CAD) is well established. Little is known, however, about factors that influence collateral formation.
METHODSWe studied the coronary angiograms of 200 consecutive patients with single-vessel coronary artery occlusion. Patients were excluded if obstructive stenoses were present in other vessels or if prior revascularization had been undertaken. Collateral circulation to the occluded artery was graded as ‘poor’ (no or incomplete filling) or ‘rich’ (complete filling). Patient characteristics, including mode of presentation, medications and CAD risk factors, were assessed.
RESULTSPositive univariate correlates of rich collaterals included increasing age [odds ratio (OR) 1.03, P = 0.016], ‘statin’ use (OR 2.50, P = 0.005), nitrate use (OR 1.96, P = 0.034), calcium-channel blocker (CCB) use (OR 4.07, P < 0.001), presentation with stable angina (OR 2.34, P = 0.006), longer time since diagnosis of CAD (OR 1.12, P = 0.002) and history of hyperlipidemia (OR 3.55, P < 0.001). Significantly poorer collateralization was observed in the setting of acute myocardial infarction (MI) (OR 0.23, P < 0.001), diabetes mellitus (OR 0.33, P = 0.003), impaired left ventricular function (OR 0.64, P = 0.015) and occlusion of the left anterior descending coronary artery (LAD) (OR 0.28, P < 0.001). On multivariate analysis, rich collateralization was associated with hyperlipidemia (P = 0.003) and CCB use (P = 0.028). Independent predictors of poor collaterals were presence of diabetes (P < 0.001), LAD occlusion (P = 0.001) and presentation with acute MI (P = 0.017).
CONCLUSIONDiabetes mellitus, occlusion of the LAD and presentation with acute MI are independently associated with poor distal vessel collateralization, whereas hyperlipidemia and use of CCBs are associated with rich collateralization. Factors determining coronary collateral formation may in turn influence outcomes after coronary artery occlusion.</description><subject>Australia - epidemiology</subject><subject>Collateral Circulation - physiology</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary Disease - complications</subject><subject>Coronary Disease - epidemiology</subject><subject>Coronary Disease - physiopathology</subject><subject>Coronary Vessels - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Risk Factors</subject><subject>Statistics as Topic</subject><subject>Ventricular Function, Left - physiology</subject><issn>0954-6928</issn><issn>1473-5830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctOxCAUhonR6Dj6CoaVu-rh2uLOTLwlJm50TSilijJFodXo04vOqCsXQE74zn_CB0KYwBEBVR8DAFECSEUBKIhSVmUB30AzwmtWiYbBJpqBErySijY7aDfnx9LERS220Q6hhJESMUN2EVMcTHrHNoZgRpdM8B9m9HE4wZ0r9dIPZhgzjj02nXuZCoM7n0cT8KvL2QXc-xD8cI9NX3BsUtl9uY3WhimXoD201ZuQ3f76nKO787PbxWV1fXNxtTi9riwTklctlc4a2tG2Z7QWjeoM9MQJ7lRj25orIAaolazprZFNI61qWasIp5xALQmbo8NV7nOKL5PLo176bF151uDilHVNFCNCygI2K9CmmHNyvX5OflkkaAL6S7D-Eax_BetvwaX1YD1japeu-2tcGy0AXwFvMRQR-SlMby7pB2fC-KD_-zj2CbKghuI</recordid><startdate>200205</startdate><enddate>200205</enddate><creator>Kilian, Jens G</creator><creator>Keech, Anthony</creator><creator>Adams, Mark R</creator><creator>Celermajer, David S</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200205</creationdate><title>Coronary collateralization: determinants of adequate distal vessel filling after arterial occlusion</title><author>Kilian, Jens G ; Keech, Anthony ; Adams, Mark R ; Celermajer, David S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3564-b26eca2d2bf327589da0f1e54e98cb74901a02c638fca6886c9b3b91424107613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Australia - epidemiology</topic><topic>Collateral Circulation - physiology</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Coronary Disease - complications</topic><topic>Coronary Disease - epidemiology</topic><topic>Coronary Disease - physiopathology</topic><topic>Coronary Vessels - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Risk Factors</topic><topic>Statistics as Topic</topic><topic>Ventricular Function, Left - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kilian, Jens G</creatorcontrib><creatorcontrib>Keech, Anthony</creatorcontrib><creatorcontrib>Adams, Mark R</creatorcontrib><creatorcontrib>Celermajer, David S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Coronary artery disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kilian, Jens G</au><au>Keech, Anthony</au><au>Adams, Mark R</au><au>Celermajer, David S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronary collateralization: determinants of adequate distal vessel filling after arterial occlusion</atitle><jtitle>Coronary artery disease</jtitle><addtitle>Coron Artery Dis</addtitle><date>2002-05</date><risdate>2002</risdate><volume>13</volume><issue>3</issue><spage>155</spage><epage>159</epage><pages>155-159</pages><issn>0954-6928</issn><eissn>1473-5830</eissn><abstract>BACKGROUNDThe protective effect of collateral vessels in coronary artery disease (CAD) is well established. Little is known, however, about factors that influence collateral formation.
METHODSWe studied the coronary angiograms of 200 consecutive patients with single-vessel coronary artery occlusion. Patients were excluded if obstructive stenoses were present in other vessels or if prior revascularization had been undertaken. Collateral circulation to the occluded artery was graded as ‘poor’ (no or incomplete filling) or ‘rich’ (complete filling). Patient characteristics, including mode of presentation, medications and CAD risk factors, were assessed.
RESULTSPositive univariate correlates of rich collaterals included increasing age [odds ratio (OR) 1.03, P = 0.016], ‘statin’ use (OR 2.50, P = 0.005), nitrate use (OR 1.96, P = 0.034), calcium-channel blocker (CCB) use (OR 4.07, P < 0.001), presentation with stable angina (OR 2.34, P = 0.006), longer time since diagnosis of CAD (OR 1.12, P = 0.002) and history of hyperlipidemia (OR 3.55, P < 0.001). Significantly poorer collateralization was observed in the setting of acute myocardial infarction (MI) (OR 0.23, P < 0.001), diabetes mellitus (OR 0.33, P = 0.003), impaired left ventricular function (OR 0.64, P = 0.015) and occlusion of the left anterior descending coronary artery (LAD) (OR 0.28, P < 0.001). On multivariate analysis, rich collateralization was associated with hyperlipidemia (P = 0.003) and CCB use (P = 0.028). Independent predictors of poor collaterals were presence of diabetes (P < 0.001), LAD occlusion (P = 0.001) and presentation with acute MI (P = 0.017).
CONCLUSIONDiabetes mellitus, occlusion of the LAD and presentation with acute MI are independently associated with poor distal vessel collateralization, whereas hyperlipidemia and use of CCBs are associated with rich collateralization. Factors determining coronary collateral formation may in turn influence outcomes after coronary artery occlusion.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>12131019</pmid><doi>10.1097/00019501-200205000-00004</doi><tpages>5</tpages></addata></record> |
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| subjects | Australia - epidemiology Collateral Circulation - physiology Coronary Artery Disease - complications Coronary Artery Disease - epidemiology Coronary Artery Disease - physiopathology Coronary Disease - complications Coronary Disease - epidemiology Coronary Disease - physiopathology Coronary Vessels - physiology Female Humans Male Middle Aged Multivariate Analysis Myocardial Infarction - complications Myocardial Infarction - epidemiology Myocardial Infarction - physiopathology Risk Factors Statistics as Topic Ventricular Function, Left - physiology |
| title | Coronary collateralization: determinants of adequate distal vessel filling after arterial occlusion |
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