A Clinical and Experimental Study on the Protective Effects of Jiangzhi Tongmai Fang on Endothelial Injury

31 cases of atherosclerosis (AS) were treated with Jiang Zhi Tong Mai Fang (降脂通脉方, formula of JZTMF), and its effect was compared with 30 cases treated with lovastatin in the control group. Clinically, the JZTMF formula showed an effect of regulating blood lipids, and therefore it was anti-atheroscl...

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Veröffentlicht in:	Journal of traditional Chinese medicine 2002-06, Vol.22 (2), p.87-92
Hauptverfasser:	Wang, Yahong, Niu, Fuling, Zhao, Mingjing, Zhong, Bei, Hao, Jinghong, Yan, Weihong, Lu, Xiying, Wang, Wei, Li, Qiang, Lin, Qian, Dai, Yanyan, Zhao, Yong, Xiao, Min, Tang, Ling, He, Lanying, Jiang, Xueying, Guo, Weiqin, Wang, Shuoren, Lu, Weixing
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Ketoprostaglandin F1 alpha - blood Animals Arteriosclerosis - blood Arteriosclerosis - drug therapy Biological and medical sciences Cholesterol, LDL - blood Drug Combinations Drugs, Chinese Herbal - therapeutic use Endothelins - blood Endothelium, Vascular - metabolism Female General pharmacology Humans Lovastatin - therapeutic use Male Medical sciences Middle Aged Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Rabbits Tropical medicine
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Zusammenfassung:	31 cases of atherosclerosis (AS) were treated with Jiang Zhi Tong Mai Fang (降脂通脉方, formula of JZTMF), and its effect was compared with 30 cases treated with lovastatin in the control group. Clinically, the JZTMF formula showed an effect of regulating blood lipids, and therefore it was anti-atherosclerotic. The mechanism is, probably, restoration of the function of endothelial cells (EC) by increasing the synthesis of 6-keto-PGF1( and decreasing the release of endothelin (ET) as evidenced in the experimental study.
ISSN:	0255-2922