Absolute Level of Epstein-Barr Virus DNA in Human Immunodeficiency Virus Type 1 Infection Is Not Predictive of AIDS-Related Non-Hodgkin Lymphoma
To study whether Epstein-Barr virus (EBV) load can be used to predict the occurrence of acquired immunodeficiency syndrome–related non-Hodgkin lymphoma (AIDS-NHL), we determined EBV load longitudinally for individuals infected with human immunodeficiency virus type 1. EBV load in peripheral blood mo...
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| Veröffentlicht in: | The Journal of infectious diseases 2002-08, Vol.186 (3), p.405-409 |
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| container_issue | 3 |
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| container_title | The Journal of infectious diseases |
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| creator | van Baarle, Debbie Wolthers, Katja C. Hovenkamp, Egbert Niesters, Hubert G. M. Osterhaus, Albert D. M. E. Miedema, Frank van Oers, Marinus H. J. |
| description | To study whether Epstein-Barr virus (EBV) load can be used to predict the occurrence of acquired immunodeficiency syndrome–related non-Hodgkin lymphoma (AIDS-NHL), we determined EBV load longitudinally for individuals infected with human immunodeficiency virus type 1. EBV load in peripheral blood mononuclear cells (PBMC) was high and displayed considerable fluctuations over time, indicating that absolute EBV load in PBMC is not predictive of the development of AIDS-NHL. EBV DNA was also detectable in serum at some time points but at a lower level |
| doi_str_mv | 10.1086/341460 |
| format | Article |
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M. ; Osterhaus, Albert D. M. E. ; Miedema, Frank ; van Oers, Marinus H. J.</creator><creatorcontrib>van Baarle, Debbie ; Wolthers, Katja C. ; Hovenkamp, Egbert ; Niesters, Hubert G. M. ; Osterhaus, Albert D. M. E. ; Miedema, Frank ; van Oers, Marinus H. J.</creatorcontrib><description>To study whether Epstein-Barr virus (EBV) load can be used to predict the occurrence of acquired immunodeficiency syndrome–related non-Hodgkin lymphoma (AIDS-NHL), we determined EBV load longitudinally for individuals infected with human immunodeficiency virus type 1. EBV load in peripheral blood mononuclear cells (PBMC) was high and displayed considerable fluctuations over time, indicating that absolute EBV load in PBMC is not predictive of the development of AIDS-NHL. EBV DNA was also detectable in serum at some time points but at a lower level</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/341460</identifier><identifier>PMID: 12134237</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>AIDS ; Biological and medical sciences ; Blood ; Concise Communications ; DNA, Viral - blood ; Epstein Barr virus infections ; Epstein-Barr virus ; Epstein-Barr Virus Infections - blood ; Epstein-Barr Virus Infections - complications ; Epstein-Barr Virus Infections - virology ; Herpesvirus 4, Human - genetics ; Herpesvirus 4, Human - growth & development ; HIV 1 ; HIV Infections - blood ; HIV Infections - complications ; HIV Infections - virology ; HIV-1 - growth & development ; Human herpesvirus 4 ; Human viral diseases ; Humans ; Infections ; Infectious diseases ; Leukocytes, Mononuclear - virology ; Longitudinal Studies ; Lymphoma ; Lymphoma, AIDS-Related - blood ; Lymphoma, AIDS-Related - virology ; Lymphoma, Non-Hodgkin - blood ; Lymphoma, Non-Hodgkin - virology ; Male ; Medical sciences ; Non Hodgkin lymphoma ; Polymerase Chain Reaction ; Predictive Value of Tests ; T lymphocytes ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load</subject><ispartof>The Journal of infectious diseases, 2002-08, Vol.186 (3), p.405-409</ispartof><rights>Copyright 2002 Infectious Diseases Society of America</rights><rights>2002 by the Infectious Diseases Society of America 2002</rights><rights>2003 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Aug 1, 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-75d1aa038254f2fc112b6f84ee1f8ffc9264cd6352b222c403a925518733c5c93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30085525$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30085525$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13826522$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12134237$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Baarle, Debbie</creatorcontrib><creatorcontrib>Wolthers, Katja C.</creatorcontrib><creatorcontrib>Hovenkamp, Egbert</creatorcontrib><creatorcontrib>Niesters, Hubert G. M.</creatorcontrib><creatorcontrib>Osterhaus, Albert D. M. E.</creatorcontrib><creatorcontrib>Miedema, Frank</creatorcontrib><creatorcontrib>van Oers, Marinus H. J.</creatorcontrib><title>Absolute Level of Epstein-Barr Virus DNA in Human Immunodeficiency Virus Type 1 Infection Is Not Predictive of AIDS-Related Non-Hodgkin Lymphoma</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>To study whether Epstein-Barr virus (EBV) load can be used to predict the occurrence of acquired immunodeficiency syndrome–related non-Hodgkin lymphoma (AIDS-NHL), we determined EBV load longitudinally for individuals infected with human immunodeficiency virus type 1. EBV load in peripheral blood mononuclear cells (PBMC) was high and displayed considerable fluctuations over time, indicating that absolute EBV load in PBMC is not predictive of the development of AIDS-NHL. EBV DNA was also detectable in serum at some time points but at a lower level</description><subject>AIDS</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Concise Communications</subject><subject>DNA, Viral - blood</subject><subject>Epstein Barr virus infections</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - blood</subject><subject>Epstein-Barr Virus Infections - complications</subject><subject>Epstein-Barr Virus Infections - virology</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Herpesvirus 4, Human - growth & development</subject><subject>HIV 1</subject><subject>HIV Infections - blood</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - growth & development</subject><subject>Human herpesvirus 4</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Leukocytes, Mononuclear - virology</subject><subject>Longitudinal Studies</subject><subject>Lymphoma</subject><subject>Lymphoma, AIDS-Related - blood</subject><subject>Lymphoma, AIDS-Related - virology</subject><subject>Lymphoma, Non-Hodgkin - blood</subject><subject>Lymphoma, Non-Hodgkin - virology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Non Hodgkin lymphoma</subject><subject>Polymerase Chain Reaction</subject><subject>Predictive Value of Tests</subject><subject>T lymphocytes</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral Load</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0t2K1DAYBuAgijuOegdKVtCzav7bHo67qzMwrKLjMuxJyKSJZrZtatIuzl14yWZp2QFBPAr0fXg_kq8APMfoLUaFeEcZZgI9ADPMaZ4JgelDMEOIkAwXZXkCnsS4RwgxKvLH4AQTTBmh-Qz8Xuyir4fewLW5NTX0Fl50sTeuzd6rEOCVC0OE55cL6Fq4HBrVwlXTDK2vjHXamVYfJrM5dAZiuGqt0b3zyUV46Xv4OZjKpS-35q58sTr_mn0xtepNleI2W_rq-03qXh-a7odv1FPwyKo6mmfTOQffPlxszpbZ-tPH1dlinWlW4D7LeYWVQrQgnFliNcZkJ2zBjMG2sFaXRDBdCcrJjhCiGaKqJJzjIqdUc13SOXgz9nbB_xxM7GXjojZ1rVrjhyhzXFIkCvxfiAsm0giR4Ku_4N4PoU2XkITQEmFB2LFNBx9jMFZ2wTUqHCRG8m6Tctxkgi-ntmHXmOrIptUl8HoCKmpV26Ba7eLRpacRPA2eg9PR-aH797AXo9nH3od7RREqOCc85dmYu_Rr_LrPVbiRIqc5l8vttSTXDOVX263c0D8UncVd</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>van Baarle, Debbie</creator><creator>Wolthers, Katja C.</creator><creator>Hovenkamp, Egbert</creator><creator>Niesters, Hubert G. M.</creator><creator>Osterhaus, Albert D. M. E.</creator><creator>Miedema, Frank</creator><creator>van Oers, Marinus H. J.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>Absolute Level of Epstein-Barr Virus DNA in Human Immunodeficiency Virus Type 1 Infection Is Not Predictive of AIDS-Related Non-Hodgkin Lymphoma</title><author>van Baarle, Debbie ; Wolthers, Katja C. ; Hovenkamp, Egbert ; Niesters, Hubert G. M. ; Osterhaus, Albert D. M. E. ; Miedema, Frank ; van Oers, Marinus H. 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Aids</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Baarle, Debbie</creatorcontrib><creatorcontrib>Wolthers, Katja C.</creatorcontrib><creatorcontrib>Hovenkamp, Egbert</creatorcontrib><creatorcontrib>Niesters, Hubert G. M.</creatorcontrib><creatorcontrib>Osterhaus, Albert D. M. E.</creatorcontrib><creatorcontrib>Miedema, Frank</creatorcontrib><creatorcontrib>van Oers, Marinus H. 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EBV load in peripheral blood mononuclear cells (PBMC) was high and displayed considerable fluctuations over time, indicating that absolute EBV load in PBMC is not predictive of the development of AIDS-NHL. EBV DNA was also detectable in serum at some time points but at a lower level</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>12134237</pmid><doi>10.1086/341460</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2002-08, Vol.186 (3), p.405-409 |
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| language | eng |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | AIDS Biological and medical sciences Blood Concise Communications DNA, Viral - blood Epstein Barr virus infections Epstein-Barr virus Epstein-Barr Virus Infections - blood Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - virology Herpesvirus 4, Human - genetics Herpesvirus 4, Human - growth & development HIV 1 HIV Infections - blood HIV Infections - complications HIV Infections - virology HIV-1 - growth & development Human herpesvirus 4 Human viral diseases Humans Infections Infectious diseases Leukocytes, Mononuclear - virology Longitudinal Studies Lymphoma Lymphoma, AIDS-Related - blood Lymphoma, AIDS-Related - virology Lymphoma, Non-Hodgkin - blood Lymphoma, Non-Hodgkin - virology Male Medical sciences Non Hodgkin lymphoma Polymerase Chain Reaction Predictive Value of Tests T lymphocytes Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load |
| title | Absolute Level of Epstein-Barr Virus DNA in Human Immunodeficiency Virus Type 1 Infection Is Not Predictive of AIDS-Related Non-Hodgkin Lymphoma |
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