Cardiorespiratory fitness and C-reactive protein among a tri-ethnic sample of women
Elevated C-reactive protein (CRP) is associated with increased coronary heart disease (CHD) risk. Cardiorespiratory fitness ("fitness") is related with lower CHD risk; however, its relationship with CRP is relatively unknown. Cross-sectional associations between fitness and plasma CRP were...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2002-07, Vol.106 (4), p.403-406 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | LAMONTE, Michael J DURSTINE, J. Larry YANOWITZ, Frank G LIM, Tobin DUBOSE, Katrina D DAVIS, Paul AINSWORTH, Barbara E |
| description | Elevated C-reactive protein (CRP) is associated with increased coronary heart disease (CHD) risk. Cardiorespiratory fitness ("fitness") is related with lower CHD risk; however, its relationship with CRP is relatively unknown.
Cross-sectional associations between fitness and plasma CRP were examined among 135 African American (AA), Native American (NA), and Caucasian (CA) women (55+/-11 year; 28+/-6 kg/m2). Fitness was assessed with a maximal treadmill exercise test. Plasma CRP concentrations were determined with the Dade Behring high-sensitivity immunoassay. Geometric mean CRP levels were 0.43, 0.25, and 0.23 mg/dL, and average maximal MET levels of fitness were 7.2, 9.1, and 10 METs for AA, NA, and CA, respectively. CRP decreased across tertiles of fitness (P=0.002), increased across tertiles of BMI (P=0.0007), and varied by race (P=0.002). After adjustment for covariates, lower CRP (P0.19 mg/dL) were 0.67 (95% CI=0.19 to 2.4) among fit (>6.5 METs) versus unfit women.
The health benefits from enhanced fitness may have an antiinflammatory mechanism. |
| doi_str_mv | 10.1161/01.CIR.0000025425.20606.69 |
| format | Article |
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Cross-sectional associations between fitness and plasma CRP were examined among 135 African American (AA), Native American (NA), and Caucasian (CA) women (55+/-11 year; 28+/-6 kg/m2). Fitness was assessed with a maximal treadmill exercise test. Plasma CRP concentrations were determined with the Dade Behring high-sensitivity immunoassay. Geometric mean CRP levels were 0.43, 0.25, and 0.23 mg/dL, and average maximal MET levels of fitness were 7.2, 9.1, and 10 METs for AA, NA, and CA, respectively. CRP decreased across tertiles of fitness (P=0.002), increased across tertiles of BMI (P=0.0007), and varied by race (P=0.002). After adjustment for covariates, lower CRP (P<0.05) was observed across tertiles of fitness among NA and CA, but not AA. Among all women, after adjusting for race and covariates, the odds of high-risk CRP (>0.19 mg/dL) were 0.67 (95% CI=0.19 to 2.4) among fit (>6.5 METs) versus unfit women.
The health benefits from enhanced fitness may have an antiinflammatory mechanism.</description><identifier>ISSN: 0009-7322</identifier><identifier>ISSN: 1524-4539</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.0000025425.20606.69</identifier><identifier>PMID: 12135936</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Biological and medical sciences ; Black or African American ; Black People ; Body Mass Index ; C-Reactive Protein - analysis ; Cardiology. Vascular system ; Coronary Disease - ethnology ; Coronary Disease - etiology ; Coronary heart disease ; Cross-Sectional Studies ; Exercise Test ; Female ; Heart ; Humans ; Indians, North American ; Medical sciences ; Middle Aged ; Physical Fitness ; Risk Factors ; White People</subject><ispartof>Circulation (New York, N.Y.), 2002-07, Vol.106 (4), p.403-406</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Jul 23, 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-5ab5e697beea22800aad9f16904a49ad2b70b8304454db44cc28176d717ca9c23</citedby><cites>FETCH-LOGICAL-c531t-5ab5e697beea22800aad9f16904a49ad2b70b8304454db44cc28176d717ca9c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13819056$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12135936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LAMONTE, Michael J</creatorcontrib><creatorcontrib>DURSTINE, J. Larry</creatorcontrib><creatorcontrib>YANOWITZ, Frank G</creatorcontrib><creatorcontrib>LIM, Tobin</creatorcontrib><creatorcontrib>DUBOSE, Katrina D</creatorcontrib><creatorcontrib>DAVIS, Paul</creatorcontrib><creatorcontrib>AINSWORTH, Barbara E</creatorcontrib><title>Cardiorespiratory fitness and C-reactive protein among a tri-ethnic sample of women</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Elevated C-reactive protein (CRP) is associated with increased coronary heart disease (CHD) risk. Cardiorespiratory fitness ("fitness") is related with lower CHD risk; however, its relationship with CRP is relatively unknown.
Cross-sectional associations between fitness and plasma CRP were examined among 135 African American (AA), Native American (NA), and Caucasian (CA) women (55+/-11 year; 28+/-6 kg/m2). Fitness was assessed with a maximal treadmill exercise test. Plasma CRP concentrations were determined with the Dade Behring high-sensitivity immunoassay. Geometric mean CRP levels were 0.43, 0.25, and 0.23 mg/dL, and average maximal MET levels of fitness were 7.2, 9.1, and 10 METs for AA, NA, and CA, respectively. CRP decreased across tertiles of fitness (P=0.002), increased across tertiles of BMI (P=0.0007), and varied by race (P=0.002). After adjustment for covariates, lower CRP (P<0.05) was observed across tertiles of fitness among NA and CA, but not AA. Among all women, after adjusting for race and covariates, the odds of high-risk CRP (>0.19 mg/dL) were 0.67 (95% CI=0.19 to 2.4) among fit (>6.5 METs) versus unfit women.
The health benefits from enhanced fitness may have an antiinflammatory mechanism.</description><subject>Biological and medical sciences</subject><subject>Black or African American</subject><subject>Black People</subject><subject>Body Mass Index</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Disease - ethnology</subject><subject>Coronary Disease - etiology</subject><subject>Coronary heart disease</subject><subject>Cross-Sectional Studies</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Indians, North American</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Physical Fitness</subject><subject>Risk Factors</subject><subject>White People</subject><issn>0009-7322</issn><issn>1524-4539</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkNtq3DAQQEVpaTZpfyGIQPtmV6Obrb4V0yaBQKBNnsVYllMFW9pK3pb8fb3JwkLmZRjmzIVDyAWwGkDDFwZ1d_2zZvvgSnJVc6aZrrV5QzaguKykEuYt2ax9UzWC8xNyWsrjWmrRqPfkBDgIZYTekF8d5iGk7Ms2ZFxSfqJjWKIvhWIcaFdlj24Jfz3d5rT4ECnOKT5QpEsOlV9-x-BowXk7eZpG-i_NPn4g70aciv94yGfk_sf3u-6qurm9vO6-3VROCVgqhb3y2jS998h5yxjiYEbQhkmUBgfeN6xvBZNSyaGX0jneQqOHBhqHxnFxRj6_7F1f-7PzZbFzKM5PE0afdsU2YAQTrVnBi1fgY9rluP5mOXDdAsB-29cXyOVUSvaj3eYwY36ywOzeu2VgV-_26N0-e7d6f-H8cGHXz344jh5Er8CnA4DF4TRmjC6UIydaMExp8R8sdIrQ</recordid><startdate>20020723</startdate><enddate>20020723</enddate><creator>LAMONTE, Michael J</creator><creator>DURSTINE, J. Larry</creator><creator>YANOWITZ, Frank G</creator><creator>LIM, Tobin</creator><creator>DUBOSE, Katrina D</creator><creator>DAVIS, Paul</creator><creator>AINSWORTH, Barbara E</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20020723</creationdate><title>Cardiorespiratory fitness and C-reactive protein among a tri-ethnic sample of women</title><author>LAMONTE, Michael J ; DURSTINE, J. Larry ; YANOWITZ, Frank G ; LIM, Tobin ; DUBOSE, Katrina D ; DAVIS, Paul ; AINSWORTH, Barbara E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-5ab5e697beea22800aad9f16904a49ad2b70b8304454db44cc28176d717ca9c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>Black or African American</topic><topic>Black People</topic><topic>Body Mass Index</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Disease - ethnology</topic><topic>Coronary Disease - etiology</topic><topic>Coronary heart disease</topic><topic>Cross-Sectional Studies</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Indians, North American</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Physical Fitness</topic><topic>Risk Factors</topic><topic>White People</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LAMONTE, Michael J</creatorcontrib><creatorcontrib>DURSTINE, J. Larry</creatorcontrib><creatorcontrib>YANOWITZ, Frank G</creatorcontrib><creatorcontrib>LIM, Tobin</creatorcontrib><creatorcontrib>DUBOSE, Katrina D</creatorcontrib><creatorcontrib>DAVIS, Paul</creatorcontrib><creatorcontrib>AINSWORTH, Barbara E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LAMONTE, Michael J</au><au>DURSTINE, J. Larry</au><au>YANOWITZ, Frank G</au><au>LIM, Tobin</au><au>DUBOSE, Katrina D</au><au>DAVIS, Paul</au><au>AINSWORTH, Barbara E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiorespiratory fitness and C-reactive protein among a tri-ethnic sample of women</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2002-07-23</date><risdate>2002</risdate><volume>106</volume><issue>4</issue><spage>403</spage><epage>406</epage><pages>403-406</pages><issn>0009-7322</issn><issn>1524-4539</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Elevated C-reactive protein (CRP) is associated with increased coronary heart disease (CHD) risk. Cardiorespiratory fitness ("fitness") is related with lower CHD risk; however, its relationship with CRP is relatively unknown.
Cross-sectional associations between fitness and plasma CRP were examined among 135 African American (AA), Native American (NA), and Caucasian (CA) women (55+/-11 year; 28+/-6 kg/m2). Fitness was assessed with a maximal treadmill exercise test. Plasma CRP concentrations were determined with the Dade Behring high-sensitivity immunoassay. Geometric mean CRP levels were 0.43, 0.25, and 0.23 mg/dL, and average maximal MET levels of fitness were 7.2, 9.1, and 10 METs for AA, NA, and CA, respectively. CRP decreased across tertiles of fitness (P=0.002), increased across tertiles of BMI (P=0.0007), and varied by race (P=0.002). After adjustment for covariates, lower CRP (P<0.05) was observed across tertiles of fitness among NA and CA, but not AA. Among all women, after adjusting for race and covariates, the odds of high-risk CRP (>0.19 mg/dL) were 0.67 (95% CI=0.19 to 2.4) among fit (>6.5 METs) versus unfit women.
The health benefits from enhanced fitness may have an antiinflammatory mechanism.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12135936</pmid><doi>10.1161/01.CIR.0000025425.20606.69</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Black or African American Black People Body Mass Index C-Reactive Protein - analysis Cardiology. Vascular system Coronary Disease - ethnology Coronary Disease - etiology Coronary heart disease Cross-Sectional Studies Exercise Test Female Heart Humans Indians, North American Medical sciences Middle Aged Physical Fitness Risk Factors White People |
| title | Cardiorespiratory fitness and C-reactive protein among a tri-ethnic sample of women |
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