Emx1 and Emx2 cooperate in initial phase of archipallium development
Emx1 and Emx2 are mouse cognates of the Drosophila head gap gene, ems. Previously we have reported that the dentate gyrus is affected in Emx2 single mutants, and defects are subtle in Emx1 single mutants. In most of the cortical region Emx1 and Emx2 functions would be redundant. To test this assumpt...
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| Veröffentlicht in: | Mechanisms of development 2004-05, Vol.121 (5), p.475-489 |
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| creator | Shinozaki, Koji Yoshida, Michio Nakamura, Miwa Aizawa, Shinichi Suda, Yoko |
| description | Emx1 and
Emx2 are mouse cognates of the
Drosophila head gap gene,
ems. Previously we have reported that the dentate gyrus is affected in
Emx2 single mutants, and defects are subtle in
Emx1 single mutants. In most of the cortical region
Emx1 and
Emx2 functions would be redundant. To test this assumption here we examined the
Emx1 and
Emx2 double mutant phenotype. In the double mutants the archipallium was transformed into the roof without establishing the signaling center at the cortical hem and without developing the choroid plexus. We propose that
Emx1 and
Emx2 cooperate in generation of the boundary between the roof and archipallium; these genes develop the archipallium against the roof. This process probably occurs immediately after the neural tube closure concomitant with the
Emx1 expression. |
| doi_str_mv | 10.1016/j.mod.2004.03.013 |
| format | Article |
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Emx2 are mouse cognates of the
Drosophila head gap gene,
ems. Previously we have reported that the dentate gyrus is affected in
Emx2 single mutants, and defects are subtle in
Emx1 single mutants. In most of the cortical region
Emx1 and
Emx2 functions would be redundant. To test this assumption here we examined the
Emx1 and
Emx2 double mutant phenotype. In the double mutants the archipallium was transformed into the roof without establishing the signaling center at the cortical hem and without developing the choroid plexus. We propose that
Emx1 and
Emx2 cooperate in generation of the boundary between the roof and archipallium; these genes develop the archipallium against the roof. This process probably occurs immediately after the neural tube closure concomitant with the
Emx1 expression.</description><identifier>ISSN: 0925-4773</identifier><identifier>EISSN: 1872-6356</identifier><identifier>DOI: 10.1016/j.mod.2004.03.013</identifier><identifier>PMID: 15147765</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Archipallium ; Choroid plexus ; Cortical hem ; Emx1 ; Emx2 ; Fimbria ; Hippocampus ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; Mice ; Mice, Knockout ; Mutation - genetics ; Telencephalon ; Telencephalon - abnormalities ; Telencephalon - cytology ; Telencephalon - embryology ; Telencephalon - metabolism ; Transcription Factors</subject><ispartof>Mechanisms of development, 2004-05, Vol.121 (5), p.475-489</ispartof><rights>2004 Elsevier Ltd</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-beb055bff940eee323394bd08117bfd9ba7e406177d06817190524d9322f5fd93</citedby><cites>FETCH-LOGICAL-c415t-beb055bff940eee323394bd08117bfd9ba7e406177d06817190524d9322f5fd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mod.2004.03.013$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15147765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shinozaki, Koji</creatorcontrib><creatorcontrib>Yoshida, Michio</creatorcontrib><creatorcontrib>Nakamura, Miwa</creatorcontrib><creatorcontrib>Aizawa, Shinichi</creatorcontrib><creatorcontrib>Suda, Yoko</creatorcontrib><title>Emx1 and Emx2 cooperate in initial phase of archipallium development</title><title>Mechanisms of development</title><addtitle>Mech Dev</addtitle><description>Emx1 and
Emx2 are mouse cognates of the
Drosophila head gap gene,
ems. Previously we have reported that the dentate gyrus is affected in
Emx2 single mutants, and defects are subtle in
Emx1 single mutants. In most of the cortical region
Emx1 and
Emx2 functions would be redundant. To test this assumption here we examined the
Emx1 and
Emx2 double mutant phenotype. In the double mutants the archipallium was transformed into the roof without establishing the signaling center at the cortical hem and without developing the choroid plexus. We propose that
Emx1 and
Emx2 cooperate in generation of the boundary between the roof and archipallium; these genes develop the archipallium against the roof. This process probably occurs immediately after the neural tube closure concomitant with the
Emx1 expression.</description><subject>Animals</subject><subject>Archipallium</subject><subject>Choroid plexus</subject><subject>Cortical hem</subject><subject>Emx1</subject><subject>Emx2</subject><subject>Fimbria</subject><subject>Hippocampus</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mutation - genetics</subject><subject>Telencephalon</subject><subject>Telencephalon - abnormalities</subject><subject>Telencephalon - cytology</subject><subject>Telencephalon - embryology</subject><subject>Telencephalon - metabolism</subject><subject>Transcription Factors</subject><issn>0925-4773</issn><issn>1872-6356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9Lw0AQxRdRbK1-AC-Sk7fEmWw2afAkWv9AwYuel012Qrck2bibFP32bmnBmzAww8x7D-bH2DVCgoD53TbprE5SgCwBngDyEzbHZZHGORf5KZtDmYo4Kwo-YxfebwEAMcdzNkOBYZ2LOXtadd8YqV5HYUij2tqBnBopMn0oMxrVRsNGeYpsEylXb8yg2tZMXaRpR60dOurHS3bWqNbT1bEv2Ofz6uPxNV6_v7w9PqzjOkMxxhVVIETVNGUGRMRTzsus0rBELKpGl5UqKIMci0JDvsQCSxBppkuepo0Id75gt4fcwdmvifwoO-NralvVk528DA4OIHgQ4kFYO-u9o0YOznTK_UgEuUcntzKgk3t0ErgM6ILn5hg-VR3pP8eRVRDcHwQUXtwZctLXhvqatHFUj1Jb80_8L7EifZ0</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Shinozaki, Koji</creator><creator>Yoshida, Michio</creator><creator>Nakamura, Miwa</creator><creator>Aizawa, Shinichi</creator><creator>Suda, Yoko</creator><general>Elsevier Ireland Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>Emx1 and Emx2 cooperate in initial phase of archipallium development</title><author>Shinozaki, Koji ; Yoshida, Michio ; Nakamura, Miwa ; Aizawa, Shinichi ; Suda, Yoko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-beb055bff940eee323394bd08117bfd9ba7e406177d06817190524d9322f5fd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Archipallium</topic><topic>Choroid plexus</topic><topic>Cortical hem</topic><topic>Emx1</topic><topic>Emx2</topic><topic>Fimbria</topic><topic>Hippocampus</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Mutation - genetics</topic><topic>Telencephalon</topic><topic>Telencephalon - abnormalities</topic><topic>Telencephalon - cytology</topic><topic>Telencephalon - embryology</topic><topic>Telencephalon - metabolism</topic><topic>Transcription Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Shinozaki, Koji</creatorcontrib><creatorcontrib>Yoshida, Michio</creatorcontrib><creatorcontrib>Nakamura, Miwa</creatorcontrib><creatorcontrib>Aizawa, Shinichi</creatorcontrib><creatorcontrib>Suda, Yoko</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shinozaki, Koji</au><au>Yoshida, Michio</au><au>Nakamura, Miwa</au><au>Aizawa, Shinichi</au><au>Suda, Yoko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emx1 and Emx2 cooperate in initial phase of archipallium development</atitle><jtitle>Mechanisms of development</jtitle><addtitle>Mech Dev</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>121</volume><issue>5</issue><spage>475</spage><epage>489</epage><pages>475-489</pages><issn>0925-4773</issn><eissn>1872-6356</eissn><abstract>Emx1 and
Emx2 are mouse cognates of the
Drosophila head gap gene,
ems. Previously we have reported that the dentate gyrus is affected in
Emx2 single mutants, and defects are subtle in
Emx1 single mutants. In most of the cortical region
Emx1 and
Emx2 functions would be redundant. To test this assumption here we examined the
Emx1 and
Emx2 double mutant phenotype. In the double mutants the archipallium was transformed into the roof without establishing the signaling center at the cortical hem and without developing the choroid plexus. We propose that
Emx1 and
Emx2 cooperate in generation of the boundary between the roof and archipallium; these genes develop the archipallium against the roof. This process probably occurs immediately after the neural tube closure concomitant with the
Emx1 expression.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>15147765</pmid><doi>10.1016/j.mod.2004.03.013</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0925-4773 1872-6356 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Archipallium Choroid plexus Cortical hem Emx1 Emx2 Fimbria Hippocampus Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Mice Mice, Knockout Mutation - genetics Telencephalon Telencephalon - abnormalities Telencephalon - cytology Telencephalon - embryology Telencephalon - metabolism Transcription Factors |
| title | Emx1 and Emx2 cooperate in initial phase of archipallium development |
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