Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of α-tocopherol
Crocin is a pharmacologically active component of Crocus sativus L. (saffron) used in traditional Chinese medicine. We report here the effects of crocin on neuronally differentiated pheochromocytoma (PC-12) cells deprived of serum/glucose. Depriving the PC-12 cells of serum/glucose caused peroxidati...
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| Veröffentlicht in: | Neuroscience letters 2004-05, Vol.362 (1), p.61-64 |
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| container_title | Neuroscience letters |
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| creator | Ochiai, Takashi Ohno, Shigekazu Soeda, Shinji Tanaka, Hiroyuki Shoyama, Yukihiro Shimeno, Hiroshi |
| description | Crocin is a pharmacologically active component of
Crocus sativus L. (saffron) used in traditional Chinese medicine. We report here the effects of crocin on neuronally differentiated pheochromocytoma (PC-12) cells deprived of serum/glucose. Depriving the PC-12 cells of serum/glucose caused peroxidation of their cell membrane lipids and decreased intercellular superoxide dismutase (SOD) activity. Treating the PC-12 cells with 10 μM crocin inhibited the formation of peroxidized lipids, partly restored the SOD activity, and maintained the neuron's morphology. These antioxidant effects of crocin were more effective than those of α-tocopherol at the same concentration. Crocin also suppressed the activation of caspase-8 caused by serum/glucose deprivation. These results together with our previous data suggest that crocin is a unique and potent antioxidant that combats oxidative stress in neurons. |
| doi_str_mv | 10.1016/j.neulet.2004.02.067 |
| format | Article |
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Crocus sativus L. (saffron) used in traditional Chinese medicine. We report here the effects of crocin on neuronally differentiated pheochromocytoma (PC-12) cells deprived of serum/glucose. Depriving the PC-12 cells of serum/glucose caused peroxidation of their cell membrane lipids and decreased intercellular superoxide dismutase (SOD) activity. Treating the PC-12 cells with 10 μM crocin inhibited the formation of peroxidized lipids, partly restored the SOD activity, and maintained the neuron's morphology. These antioxidant effects of crocin were more effective than those of α-tocopherol at the same concentration. Crocin also suppressed the activation of caspase-8 caused by serum/glucose deprivation. These results together with our previous data suggest that crocin is a unique and potent antioxidant that combats oxidative stress in neurons.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2004.02.067</identifier><identifier>PMID: 15147781</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>alpha-Tocopherol - chemistry ; alpha-Tocopherol - pharmacology ; Animals ; Antioxidant ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Biological and medical sciences ; Carotenoids - chemistry ; Carotenoids - pharmacology ; Caspases - metabolism ; Cell Death - physiology ; Crocin ; Crocus sativus ; Dose-Response Relationship, Drug ; Fundamental and applied biological sciences. Psychology ; Lipid peroxidation ; Neuronal death ; PC-12 cells ; PC12 Cells ; Rats ; Superoxide dismutase ; Vertebrates: nervous system and sense organs ; α-Tocopherol</subject><ispartof>Neuroscience letters, 2004-05, Vol.362 (1), p.61-64</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-41bae3bca737274f685c35a030be336fc8038dd3ca6a6b74ea94d714bfcea3d83</citedby><cites>FETCH-LOGICAL-c452t-41bae3bca737274f685c35a030be336fc8038dd3ca6a6b74ea94d714bfcea3d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394004002629$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15724217$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15147781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ochiai, Takashi</creatorcontrib><creatorcontrib>Ohno, Shigekazu</creatorcontrib><creatorcontrib>Soeda, Shinji</creatorcontrib><creatorcontrib>Tanaka, Hiroyuki</creatorcontrib><creatorcontrib>Shoyama, Yukihiro</creatorcontrib><creatorcontrib>Shimeno, Hiroshi</creatorcontrib><title>Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of α-tocopherol</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Crocin is a pharmacologically active component of
Crocus sativus L. (saffron) used in traditional Chinese medicine. We report here the effects of crocin on neuronally differentiated pheochromocytoma (PC-12) cells deprived of serum/glucose. Depriving the PC-12 cells of serum/glucose caused peroxidation of their cell membrane lipids and decreased intercellular superoxide dismutase (SOD) activity. Treating the PC-12 cells with 10 μM crocin inhibited the formation of peroxidized lipids, partly restored the SOD activity, and maintained the neuron's morphology. These antioxidant effects of crocin were more effective than those of α-tocopherol at the same concentration. Crocin also suppressed the activation of caspase-8 caused by serum/glucose deprivation. These results together with our previous data suggest that crocin is a unique and potent antioxidant that combats oxidative stress in neurons.</description><subject>alpha-Tocopherol - chemistry</subject><subject>alpha-Tocopherol - pharmacology</subject><subject>Animals</subject><subject>Antioxidant</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carotenoids - chemistry</subject><subject>Carotenoids - pharmacology</subject><subject>Caspases - metabolism</subject><subject>Cell Death - physiology</subject><subject>Crocin</subject><subject>Crocus sativus</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lipid peroxidation</subject><subject>Neuronal death</subject><subject>PC-12 cells</subject><subject>PC12 Cells</subject><subject>Rats</subject><subject>Superoxide dismutase</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>α-Tocopherol</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2KFDEQx4Mo7uzqG4jk4rIeus1Xd7ovggx-wYIe9BzS6YqToTsZk8yyc9l32hfxmUwzA-5pvaQg_OpHVf0RekVJTQlt321rD_sJcs0IETVhNWnlE7SinWSV7CV7ilaEE1HxXpAzdJ7SlhDS0EY8R2e0oULKjq7Q3ToG4zzeRbgBnxPOG8Aj6LzBweKoM95tIJhNDPPB5DBrfPV9XVH2FhuYpoSHA3alS_vswq0bS8VgLZjyl3IM_hfEotS-PCHB4vxzX-VgQtHGML1Az6yeErw81Qv089PHH-sv1fW3z1_XH64rIxqWK0EHDXwwWnLJpLBt1xje6LLfAJy31nSEd-PIjW51O0gBuhejpGKwBjQfO36BLo_eXQy_95Cyml1aNtAewj4pSXvWNx0r4NWjYDlv0zVSUPJfJ5Vtz7loCyiOoIkhpQhW7aKbdTwoStSSpdqqY5ZqyVIRpkqWpe31yb8fZhj_NZ3CK8CbE6CT0ZON2huXHnCSCUYX0fsjB-XCNw6iSsaBNzC6WJJSY3CPT_IXZwTAjw</recordid><startdate>20040513</startdate><enddate>20040513</enddate><creator>Ochiai, Takashi</creator><creator>Ohno, Shigekazu</creator><creator>Soeda, Shinji</creator><creator>Tanaka, Hiroyuki</creator><creator>Shoyama, Yukihiro</creator><creator>Shimeno, Hiroshi</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20040513</creationdate><title>Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of α-tocopherol</title><author>Ochiai, Takashi ; Ohno, Shigekazu ; Soeda, Shinji ; Tanaka, Hiroyuki ; Shoyama, Yukihiro ; Shimeno, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-41bae3bca737274f685c35a030be336fc8038dd3ca6a6b74ea94d714bfcea3d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>alpha-Tocopherol - chemistry</topic><topic>alpha-Tocopherol - pharmacology</topic><topic>Animals</topic><topic>Antioxidant</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carotenoids - chemistry</topic><topic>Carotenoids - pharmacology</topic><topic>Caspases - metabolism</topic><topic>Cell Death - physiology</topic><topic>Crocin</topic><topic>Crocus sativus</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Lipid peroxidation</topic><topic>Neuronal death</topic><topic>PC-12 cells</topic><topic>PC12 Cells</topic><topic>Rats</topic><topic>Superoxide dismutase</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>α-Tocopherol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ochiai, Takashi</creatorcontrib><creatorcontrib>Ohno, Shigekazu</creatorcontrib><creatorcontrib>Soeda, Shinji</creatorcontrib><creatorcontrib>Tanaka, Hiroyuki</creatorcontrib><creatorcontrib>Shoyama, Yukihiro</creatorcontrib><creatorcontrib>Shimeno, Hiroshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ochiai, Takashi</au><au>Ohno, Shigekazu</au><au>Soeda, Shinji</au><au>Tanaka, Hiroyuki</au><au>Shoyama, Yukihiro</au><au>Shimeno, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of α-tocopherol</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2004-05-13</date><risdate>2004</risdate><volume>362</volume><issue>1</issue><spage>61</spage><epage>64</epage><pages>61-64</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Crocin is a pharmacologically active component of
Crocus sativus L. (saffron) used in traditional Chinese medicine. We report here the effects of crocin on neuronally differentiated pheochromocytoma (PC-12) cells deprived of serum/glucose. Depriving the PC-12 cells of serum/glucose caused peroxidation of their cell membrane lipids and decreased intercellular superoxide dismutase (SOD) activity. Treating the PC-12 cells with 10 μM crocin inhibited the formation of peroxidized lipids, partly restored the SOD activity, and maintained the neuron's morphology. These antioxidant effects of crocin were more effective than those of α-tocopherol at the same concentration. Crocin also suppressed the activation of caspase-8 caused by serum/glucose deprivation. These results together with our previous data suggest that crocin is a unique and potent antioxidant that combats oxidative stress in neurons.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15147781</pmid><doi>10.1016/j.neulet.2004.02.067</doi><tpages>4</tpages></addata></record> |
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| subjects | alpha-Tocopherol - chemistry alpha-Tocopherol - pharmacology Animals Antioxidant Antioxidants - chemistry Antioxidants - pharmacology Biological and medical sciences Carotenoids - chemistry Carotenoids - pharmacology Caspases - metabolism Cell Death - physiology Crocin Crocus sativus Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Lipid peroxidation Neuronal death PC-12 cells PC12 Cells Rats Superoxide dismutase Vertebrates: nervous system and sense organs α-Tocopherol |
| title | Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of α-tocopherol |
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