Protein kinase A-mediated phosphorylation of HERG potassium channels in a human cell line

To investigate the molecular mechanism of human ether-a-go-go-related gene (HERG) potassium channels regulated by protein kinase A (PKA) in a human cell line. HERG channels were stably expressed in human embryonic kidney (HEK) 293 cells, and currents were measured with the patch clamp technique. The...

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Veröffentlicht in:	Chinese medical journal 2002-05, Vol.115 (5), p.668-676
Hauptverfasser:	Wei, Zhang, Thomas, Dierk, Karle, Christoph A, Kathöfer, Sven, Schenkel, Johannes, Kreye, Volker A W, Ficker, Eckhard, Wible, Barbara A, Kiehn, Johann
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology 8-Bromo Cyclic Adenosine Monophosphate - pharmacology Adenylyl Cyclases - metabolism Animals Anti-Arrhythmia Agents - pharmacology Cation Transport Proteins Cell Line Colforsin - pharmacology Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism DNA-Binding Proteins Enzyme Activation - drug effects ERG1 Potassium Channel Ether-A-Go-Go Potassium Channels Female Humans Membrane Potentials - drug effects Microinjections Oocytes Patch-Clamp Techniques Phenethylamines - pharmacology Phosphodiesterase Inhibitors - pharmacology Phosphoric Diester Hydrolases - drug effects Phosphoric Diester Hydrolases - metabolism Phosphorylation Potassium Channels - genetics Potassium Channels - metabolism Potassium Channels - physiology Potassium Channels, Voltage-Gated RNA, Complementary - administration & dosage RNA, Complementary - genetics Sulfonamides - pharmacology Trans-Activators Transcriptional Regulator ERG Xenopus laevis
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