Comparative effects of methamphetamine and nicotine on the striatal [11C]raclopride binding in unanesthetized monkeys

Although a very large literature exists on the in vitro, ex vivo, and in vivo effects of nicotine on dopamine release in rodents, similar data in primates are scant. This study was initiated to compare methamphetamine to nicotine given i.v. to normal unanesthetized monkeys using positron emission to...

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Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 2002-09, Vol.45 (4), p.207-212
Hauptverfasser:	Tsukada, Hideo, Miyasato, Katsumasa, Kakiuchi, Takeharu, Nishiyama, Shingo, Harada, Norihiro, Domino, Edward F.
Format:	Artikel
Sprache:	eng
Schlagworte:	[11C]raclopride Anesthesia Animals Arousal Binding, Competitive - drug effects Carbon Radioisotopes Central Nervous System Stimulants - pharmacology Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine Antagonists - metabolism Dopamine Antagonists - pharmacology dopamine release Macaca mulatta Male Methamphetamine - pharmacology monkey brain nicotine Nicotine - pharmacology Nicotinic Agonists - pharmacology PET Raclopride - metabolism Raclopride - pharmacology tobacco smoking
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