Thyrocytes Isolated from Autoimmune-Diseased Thyroids Secrete Soluble Tumor Necrosis Factor-R1 That Is Related to Their Elevated Protein Kinase C Activity

Soluble tumor necrosis factor (TNF)-α receptors have the potential to modulate TNF-α activity during autoimmune thyroiditis. In this study we examined cell-surface TNF-α receptors and soluble TNF-α receptor production by thyrocytes from normal and MRL-lpr -/- (diseased) mice, which spontaneously dev...

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Veröffentlicht in:	Thyroid (New York, N.Y.) N.Y.), 2004-04, Vol.14 (4), p.249-262
Hauptverfasser:	LaBue, M., Colburn, K.K., Green, L.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Disease Models, Animal Laboratory Research Reports Mice Mice, Inbred MRL lpr Mice, Knockout Protein Kinase C - metabolism Receptors, Tumor Necrosis Factor, Type I - biosynthesis Receptors, Tumor Necrosis Factor, Type I - physiology Reference Values Space life sciences Thyroid Gland - pathology Thyroid Gland - physiology Thyroiditis, Autoimmune - enzymology Thyroiditis, Autoimmune - physiopathology
Online-Zugang:	Volltext
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