Increase in Pulse Pressure Relates to Diabetes Mellitus and Low HDL Cholesterol, but Not to Hyperlipidemia in Hypertensive Patients Aged 50 Years or Older
Higher pulse pressure is associated with higher cardiovascular risk. We investigated the relationship between pulse pressure and known metabolic risk factors in hypertensive patients who had not experienced stroke or myocardial infarction. In a multicenter cross-sectional survey made in 1995, we reg...
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| Veröffentlicht in: | Hypertension Research 2002, Vol.25(3), pp.335-341 |
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| creator | MIYAGI, Takako MURATANI, Hiromi KIMURA, Yorio FUKIYAMA, Koshiro KAWANO, Yuhei FUJII, Jun ABE, Keishi KUWAJIMA, Iwao ISHII, Masao SHIOMI, Toshiaki MIKAMI, Hiroshi IBAYASHI, Setsuro OMAE, Teruo |
| description | Higher pulse pressure is associated with higher cardiovascular risk. We investigated the relationship between pulse pressure and known metabolic risk factors in hypertensive patients who had not experienced stroke or myocardial infarction. In a multicenter cross-sectional survey made in 1995, we registered 939 hypertensive patients aged ≥50 years. Of these, 734 had never experienced stroke or myocardial infarction. We divided these 734 patients into two groups based on the value of their pulse pressures: 396 patients with a pulse pressure ≥60 mmHg, and 338 patients with a pulse pressure |
| doi_str_mv | 10.1291/hypres.25.335 |
| format | Article |
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We investigated the relationship between pulse pressure and known metabolic risk factors in hypertensive patients who had not experienced stroke or myocardial infarction. In a multicenter cross-sectional survey made in 1995, we registered 939 hypertensive patients aged ≥50 years. Of these, 734 had never experienced stroke or myocardial infarction. We divided these 734 patients into two groups based on the value of their pulse pressures: 396 patients with a pulse pressure ≥60 mmHg, and 338 patients with a pulse pressure<60 mmHg. The average pulse pressure value was 72±12 mmHg in the former group, and 49±8 mmHg in the latter group. The former group exhibited advanced age, a higher women-to-men ratio, lower high-density lipoprotein (HDL) cholesterol, and higher systolic and lower diastolic blood pressure. Diabetes mellitus (DM) and left ventricular hypertrophy were more frequently noticed in the former group than in the latter group. The prevalence of hyperlipidemia, however, was similar in the two groups. The association of pulse pressure with DM and low HDL cholesterol was statistically significant by multiple logistic analysis adjusted for age, sex, and other known cardiovascular risk factors. In conclusion, pulse pressure increases with advancing age. DM made a substantially larger contribution to the increase in pulse pressure than hyperlipidemia. (Hypertens Res 2002; 25: 335-341)</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1291/hypres.25.335</identifier><identifier>PMID: 12135310</identifier><language>eng</language><publisher>England: The Japanese Society of Hypertension</publisher><subject>Adrenergic beta-Antagonists - pharmacology ; Aged ; Blood Pressure - physiology ; Cholesterol, HDL - blood ; Cross-Sectional Studies ; diabetes mellitus ; Diabetes Mellitus - physiopathology ; Female ; HDL-cholesterol ; Humans ; hyperlipidemia ; Hyperlipidemias - physiopathology ; Hypertension - blood ; Hypertension - physiopathology ; Male ; Middle Aged ; pulse pressure ; Risk Factors ; Smoking</subject><ispartof>Hypertension Research, 2002, Vol.25(3), pp.335-341</ispartof><rights>2002 by the Japanese Society of Hypertension</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-cf9429fdd433d3c38e666befeeb66ed2de2f4cecf628b3731e31337cada3ac4a3</citedby><cites>FETCH-LOGICAL-c477t-cf9429fdd433d3c38e666befeeb66ed2de2f4cecf628b3731e31337cada3ac4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12135310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MIYAGI, Takako</creatorcontrib><creatorcontrib>MURATANI, Hiromi</creatorcontrib><creatorcontrib>KIMURA, Yorio</creatorcontrib><creatorcontrib>FUKIYAMA, Koshiro</creatorcontrib><creatorcontrib>KAWANO, Yuhei</creatorcontrib><creatorcontrib>FUJII, Jun</creatorcontrib><creatorcontrib>ABE, Keishi</creatorcontrib><creatorcontrib>KUWAJIMA, Iwao</creatorcontrib><creatorcontrib>ISHII, Masao</creatorcontrib><creatorcontrib>SHIOMI, Toshiaki</creatorcontrib><creatorcontrib>MIKAMI, Hiroshi</creatorcontrib><creatorcontrib>IBAYASHI, Setsuro</creatorcontrib><creatorcontrib>OMAE, Teruo</creatorcontrib><title>Increase in Pulse Pressure Relates to Diabetes Mellitus and Low HDL Cholesterol, but Not to Hyperlipidemia in Hypertensive Patients Aged 50 Years or Older</title><title>Hypertension Research</title><addtitle>Hypertension Research</addtitle><description>Higher pulse pressure is associated with higher cardiovascular risk. We investigated the relationship between pulse pressure and known metabolic risk factors in hypertensive patients who had not experienced stroke or myocardial infarction. In a multicenter cross-sectional survey made in 1995, we registered 939 hypertensive patients aged ≥50 years. Of these, 734 had never experienced stroke or myocardial infarction. We divided these 734 patients into two groups based on the value of their pulse pressures: 396 patients with a pulse pressure ≥60 mmHg, and 338 patients with a pulse pressure<60 mmHg. The average pulse pressure value was 72±12 mmHg in the former group, and 49±8 mmHg in the latter group. The former group exhibited advanced age, a higher women-to-men ratio, lower high-density lipoprotein (HDL) cholesterol, and higher systolic and lower diastolic blood pressure. Diabetes mellitus (DM) and left ventricular hypertrophy were more frequently noticed in the former group than in the latter group. The prevalence of hyperlipidemia, however, was similar in the two groups. The association of pulse pressure with DM and low HDL cholesterol was statistically significant by multiple logistic analysis adjusted for age, sex, and other known cardiovascular risk factors. In conclusion, pulse pressure increases with advancing age. DM made a substantially larger contribution to the increase in pulse pressure than hyperlipidemia. (Hypertens Res 2002; 25: 335-341)</description><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Aged</subject><subject>Blood Pressure - physiology</subject><subject>Cholesterol, HDL - blood</subject><subject>Cross-Sectional Studies</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Female</subject><subject>HDL-cholesterol</subject><subject>Humans</subject><subject>hyperlipidemia</subject><subject>Hyperlipidemias - physiopathology</subject><subject>Hypertension - blood</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>pulse pressure</subject><subject>Risk Factors</subject><subject>Smoking</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkU1vEzEQhi0EoqFw5Ip84sSG9cd642NJKakUaIXgwMny2rONK2e92F6q_BV-LQ4bFS6e0fjxO555EXpN6iWhkrzfHcYIaUmbJWPNE7QgjK8qTgl_iha1JKKSgokz9CKl-7qmq0aS5-iMUMIaRuoF-n09mAg6AXYDvp18SW6LXpoi4K_gdYaEc8CXTndwzD-D9y5PCevB4m14wJvLLV7vgoeUIQb_DndTxl9CPr7aHEaI3o3Owt7pY4e_lQxDcr9KI50dDDnhizuwuKnxD9Ax4RDxjbcQX6JnvS4fenWK5-j71cdv6021vfl0vb7YVoa3ba5MLzmVvbWcMcsMW4EQooMeoBMCLLVAe27A9IKuOtYyAoww1hptNdOGa3aO3s66Yww_pzKH2rtkypx6gDAl1RJJuRSygNUMmhhSitCrMbq9jgdFanU0Q81mKNqoYkbh35yEp24P9h992n4BPszAfcr6Dh4BHbMzHv6Xm4-i-nhpdjoqGNgfiKyhtQ</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>MIYAGI, Takako</creator><creator>MURATANI, Hiromi</creator><creator>KIMURA, Yorio</creator><creator>FUKIYAMA, Koshiro</creator><creator>KAWANO, Yuhei</creator><creator>FUJII, Jun</creator><creator>ABE, Keishi</creator><creator>KUWAJIMA, Iwao</creator><creator>ISHII, Masao</creator><creator>SHIOMI, Toshiaki</creator><creator>MIKAMI, Hiroshi</creator><creator>IBAYASHI, Setsuro</creator><creator>OMAE, Teruo</creator><general>The Japanese Society of Hypertension</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>Increase in Pulse Pressure Relates to Diabetes Mellitus and Low HDL Cholesterol, but Not to Hyperlipidemia in Hypertensive Patients Aged 50 Years or Older</title><author>MIYAGI, Takako ; MURATANI, Hiromi ; KIMURA, Yorio ; FUKIYAMA, Koshiro ; KAWANO, Yuhei ; FUJII, Jun ; ABE, Keishi ; KUWAJIMA, Iwao ; ISHII, Masao ; SHIOMI, Toshiaki ; MIKAMI, Hiroshi ; IBAYASHI, Setsuro ; OMAE, Teruo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-cf9429fdd433d3c38e666befeeb66ed2de2f4cecf628b3731e31337cada3ac4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Aged</topic><topic>Blood Pressure - physiology</topic><topic>Cholesterol, HDL - blood</topic><topic>Cross-Sectional Studies</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Female</topic><topic>HDL-cholesterol</topic><topic>Humans</topic><topic>hyperlipidemia</topic><topic>Hyperlipidemias - physiopathology</topic><topic>Hypertension - blood</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>pulse pressure</topic><topic>Risk Factors</topic><topic>Smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MIYAGI, Takako</creatorcontrib><creatorcontrib>MURATANI, Hiromi</creatorcontrib><creatorcontrib>KIMURA, Yorio</creatorcontrib><creatorcontrib>FUKIYAMA, Koshiro</creatorcontrib><creatorcontrib>KAWANO, Yuhei</creatorcontrib><creatorcontrib>FUJII, Jun</creatorcontrib><creatorcontrib>ABE, Keishi</creatorcontrib><creatorcontrib>KUWAJIMA, Iwao</creatorcontrib><creatorcontrib>ISHII, Masao</creatorcontrib><creatorcontrib>SHIOMI, Toshiaki</creatorcontrib><creatorcontrib>MIKAMI, Hiroshi</creatorcontrib><creatorcontrib>IBAYASHI, Setsuro</creatorcontrib><creatorcontrib>OMAE, Teruo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MIYAGI, Takako</au><au>MURATANI, Hiromi</au><au>KIMURA, Yorio</au><au>FUKIYAMA, Koshiro</au><au>KAWANO, Yuhei</au><au>FUJII, Jun</au><au>ABE, Keishi</au><au>KUWAJIMA, Iwao</au><au>ISHII, Masao</au><au>SHIOMI, Toshiaki</au><au>MIKAMI, Hiroshi</au><au>IBAYASHI, Setsuro</au><au>OMAE, Teruo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increase in Pulse Pressure Relates to Diabetes Mellitus and Low HDL Cholesterol, but Not to Hyperlipidemia in Hypertensive Patients Aged 50 Years or Older</atitle><jtitle>Hypertension Research</jtitle><addtitle>Hypertension Research</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>25</volume><issue>3</issue><spage>335</spage><epage>341</epage><pages>335-341</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract>Higher pulse pressure is associated with higher cardiovascular risk. We investigated the relationship between pulse pressure and known metabolic risk factors in hypertensive patients who had not experienced stroke or myocardial infarction. In a multicenter cross-sectional survey made in 1995, we registered 939 hypertensive patients aged ≥50 years. Of these, 734 had never experienced stroke or myocardial infarction. We divided these 734 patients into two groups based on the value of their pulse pressures: 396 patients with a pulse pressure ≥60 mmHg, and 338 patients with a pulse pressure<60 mmHg. The average pulse pressure value was 72±12 mmHg in the former group, and 49±8 mmHg in the latter group. The former group exhibited advanced age, a higher women-to-men ratio, lower high-density lipoprotein (HDL) cholesterol, and higher systolic and lower diastolic blood pressure. Diabetes mellitus (DM) and left ventricular hypertrophy were more frequently noticed in the former group than in the latter group. The prevalence of hyperlipidemia, however, was similar in the two groups. The association of pulse pressure with DM and low HDL cholesterol was statistically significant by multiple logistic analysis adjusted for age, sex, and other known cardiovascular risk factors. In conclusion, pulse pressure increases with advancing age. DM made a substantially larger contribution to the increase in pulse pressure than hyperlipidemia. (Hypertens Res 2002; 25: 335-341)</abstract><cop>England</cop><pub>The Japanese Society of Hypertension</pub><pmid>12135310</pmid><doi>10.1291/hypres.25.335</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenergic beta-Antagonists - pharmacology Aged Blood Pressure - physiology Cholesterol, HDL - blood Cross-Sectional Studies diabetes mellitus Diabetes Mellitus - physiopathology Female HDL-cholesterol Humans hyperlipidemia Hyperlipidemias - physiopathology Hypertension - blood Hypertension - physiopathology Male Middle Aged pulse pressure Risk Factors Smoking |
| title | Increase in Pulse Pressure Relates to Diabetes Mellitus and Low HDL Cholesterol, but Not to Hyperlipidemia in Hypertensive Patients Aged 50 Years or Older |
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