Direct Reaction between Shikonin and Thiols Induces Apoptosis in HL60 Cells

Shikonin (β-alkannin), a naphthoquinone compound, was found to induce apoptotic features such as chromatin condensation, DNA fragmentation, and activation of caspase 3 in HL60 cells. The mechanism was examined in terms of oxidative stress in the cells. Exposure of the cells to shikonin greatly reduc...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2002, Vol.25(7), pp.827-832
Hauptverfasser:	Gao, Dayuan, Hiromura, Makoto, Yasui, Hiroyuki, Sakurai, Hiromu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Antineoplastic agents Antineoplastic Agents, Phytogenic - pharmacology apoptosis Apoptosis - drug effects Biological and medical sciences Caspase 3 Caspases - metabolism Chemotherapy DNA fragmentation DNA Fragmentation - drug effects electron spin resonance (ESR) Enzyme Activation General pharmacology glutathione HL-60 Cells - drug effects HL-60 Cells - metabolism Humans Lipid Peroxides - metabolism Medical sciences Naphthoquinones - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments protein thiol shikonin Sulfhydryl Compounds - metabolism
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