Simultaneous determination of Z-SU5416 and its interconvertible geometric E-isomer in rat plasma by LC/MS/MS
SU5416 is a selective inhibitor of vascular endothelial growth factor (VEGF) receptor, which plays a major role in vascular angiogenesis. SU5416 exists as the thermodynamically stable and pharmacologically active cis isomer (Z-isomer) in the solid state. In light-exposed solutions the unstable trans...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2004-05, Vol.35 (3), p.513-522 |
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| creator | Zhao, Yeping Sukbuntherng, Juthamas Antonian, Lida |
| description | SU5416 is a selective inhibitor of vascular endothelial growth factor (VEGF) receptor, which plays a major role in vascular angiogenesis. SU5416 exists as the thermodynamically stable and pharmacologically active
cis isomer (Z-isomer) in the solid state. In light-exposed solutions the unstable
trans isomer (E-isomer) is formed. The E-isomer is unstable for synthesis and isolation and the analytical standard of the E-isomer is unavailable. A new, simple, fast and reliable LC/MS/MS method was developed to quantify both isomers simultaneously in rat plasma samples in order to support the study of disposition kinetics of Z- and E-SU5416. This method is sensitive (LOQ=0.5
ng/ml), reproducible, and has a wide linear range (0.5–2500
ng/ml). |
| doi_str_mv | 10.1016/j.jpba.2003.08.017 |
| format | Article |
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cis isomer (Z-isomer) in the solid state. In light-exposed solutions the unstable
trans isomer (E-isomer) is formed. The E-isomer is unstable for synthesis and isolation and the analytical standard of the E-isomer is unavailable. A new, simple, fast and reliable LC/MS/MS method was developed to quantify both isomers simultaneously in rat plasma samples in order to support the study of disposition kinetics of Z- and E-SU5416. This method is sensitive (LOQ=0.5
ng/ml), reproducible, and has a wide linear range (0.5–2500
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cis isomer (Z-isomer) in the solid state. In light-exposed solutions the unstable
trans isomer (E-isomer) is formed. The E-isomer is unstable for synthesis and isolation and the analytical standard of the E-isomer is unavailable. A new, simple, fast and reliable LC/MS/MS method was developed to quantify both isomers simultaneously in rat plasma samples in order to support the study of disposition kinetics of Z- and E-SU5416. This method is sensitive (LOQ=0.5
ng/ml), reproducible, and has a wide linear range (0.5–2500
ng/ml).</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>E- and Z-isomers</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gas Chromatography-Mass Spectrometry - methods</subject><subject>General pharmacology</subject><subject>Indoles - blood</subject><subject>LC/MS/MS</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrroles - blood</subject><subject>Rats</subject><subject>Stereoisomerism</subject><subject>Technology, Pharmaceutical - methods</subject><subject>Z-SU5416</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpaTZJ_0APRZf2ZmdkyZYFvZQlTQpbetgESi9iLI-LFn9sJW0g_75adqE9BQmkw_O-zDyMvRdQChDNza7c7TssKwBZQluC0K_YSrRaFlWjfr5mK9BSFBra-oJdxrgDgFoY9ZZdiFpIbXSzYuPWT4cx4UzLIfKeEoXJz5j8MvNl4L-K7WOtRMNx7rlPkfs5E26Znygk343Ef9MyUQre8dvCx_wPmeEBE9-PGCfk3TPfrG--b_O9Zm8GHCO9O79X7PHr7cP6vtj8uPu2_rIpnGyrVKBA5ZTOx7hatY0yNIDRndFU9bo3CC2oioCaujF6EIiy164bWgNSdjXKK_bp1LsPy58DxWQnHx2N42lNq4WpZA5nsDqBLiwxBhrsPvgJw7MVYI-O7c4eHdujYwutzY5z6MO5_dBN1P-LnKVm4OMZwOhwHALOzsf_OK1UJavMfT5xlF08eQo2Ok-zo94Hcsn2i39pjr_iwJl4</recordid><startdate>20040528</startdate><enddate>20040528</enddate><creator>Zhao, Yeping</creator><creator>Sukbuntherng, Juthamas</creator><creator>Antonian, Lida</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040528</creationdate><title>Simultaneous determination of Z-SU5416 and its interconvertible geometric E-isomer in rat plasma by LC/MS/MS</title><author>Zhao, Yeping ; Sukbuntherng, Juthamas ; Antonian, Lida</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-a1a4c474749c548649ef097b97e2d7d9a08042e0e65697f1aa3d7cbf89033b5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>E- and Z-isomers</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gas Chromatography-Mass Spectrometry - methods</topic><topic>General pharmacology</topic><topic>Indoles - blood</topic><topic>LC/MS/MS</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrroles - blood</topic><topic>Rats</topic><topic>Stereoisomerism</topic><topic>Technology, Pharmaceutical - methods</topic><topic>Z-SU5416</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Yeping</creatorcontrib><creatorcontrib>Sukbuntherng, Juthamas</creatorcontrib><creatorcontrib>Antonian, Lida</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Yeping</au><au>Sukbuntherng, Juthamas</au><au>Antonian, Lida</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous determination of Z-SU5416 and its interconvertible geometric E-isomer in rat plasma by LC/MS/MS</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2004-05-28</date><risdate>2004</risdate><volume>35</volume><issue>3</issue><spage>513</spage><epage>522</epage><pages>513-522</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>SU5416 is a selective inhibitor of vascular endothelial growth factor (VEGF) receptor, which plays a major role in vascular angiogenesis. SU5416 exists as the thermodynamically stable and pharmacologically active
cis isomer (Z-isomer) in the solid state. In light-exposed solutions the unstable
trans isomer (E-isomer) is formed. The E-isomer is unstable for synthesis and isolation and the analytical standard of the E-isomer is unavailable. A new, simple, fast and reliable LC/MS/MS method was developed to quantify both isomers simultaneously in rat plasma samples in order to support the study of disposition kinetics of Z- and E-SU5416. This method is sensitive (LOQ=0.5
ng/ml), reproducible, and has a wide linear range (0.5–2500
ng/ml).</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15137976</pmid><doi>10.1016/j.jpba.2003.08.017</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of pharmaceutical and biomedical analysis, 2004-05, Vol.35 (3), p.513-522 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences E- and Z-isomers Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry - methods General pharmacology Indoles - blood LC/MS/MS Medical sciences Pharmacology. Drug treatments Pyrroles - blood Rats Stereoisomerism Technology, Pharmaceutical - methods Z-SU5416 |
| title | Simultaneous determination of Z-SU5416 and its interconvertible geometric E-isomer in rat plasma by LC/MS/MS |
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