Suppression of Macrophage Function by Substances with a Molecular Weight Lower than 3000 Da in B16 Melanoma-Conditioned Medium

In the present study, B16 melanoma cells were found to produce inhibitory and cytotoxic substances with a molecular weight lower than 3000 Da against macrophages in a conditioned medium. The B16 melanoma-conditioned medium suppressed nitric oxide (NO) production only by mouse peritoneal macrophages...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2002, Vol.25(7), pp.907-912
Hauptverfasser:	Inoue, Makoto, Ohno, Takamasa, Ogihara, Yukio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B16 melanoma Biological and medical sciences Cell Line Cell physiology Cell Survival - drug effects Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Culture Media, Conditioned - metabolism cytotoxicity Fundamental and applied biological sciences. Psychology Hepatocytes - cytology Humans macrophage Macrophages, Peritoneal - metabolism Melanoma, Experimental - metabolism Melanoma, Experimental - pathology metastasis Mice Mice, Inbred C57BL Molecular and cellular biology Molecular Weight nitric oxide Nitric Oxide - antagonists & inhibitors Rats Rats, Wistar
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