A Polymorphism in the Cyclooxygenase 2 Gene as an Inherited Protective Factor Against Myocardial Infarction and Stroke

CONTEXT Myocardial infarction (MI) and ischemic stroke are thought to be caused by matrix digestion by metalloproteinases (MMPs) leading to rupture of atherosclerotic plaques. Production of macrophage MMP-2 and MMP-9 is induced by cyclooxygenase 2 (COX-2) and prostaglandin E2 synthesis. Although COX...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2004-05, Vol.291 (18), p.2221-2228
Hauptverfasser:	Cipollone, Francesco, Toniato, Elena, Martinotti, Stefano, Fazia, Maria, Iezzi, Annalisa, Cuccurullo, Chiara, Pini, Barbara, Ursi, Sebastiano, Vitullo, Gianfranco, Averna, Maurizio, Arca, Marcello, Montali, Anna, Campagna, Filomena, Ucchino, Sante, Spigonardo, Francesco, Taddei, Stefano, Virdis, Agostino, Ciabattoni, Giovanni, Notarbartolo, Alberto, Cuccurullo, Franco, Mezzetti, Andrea, for the Identification of New Elements of Plaque Stability (INES) Study Group
Format:	Artikel
Sprache:	eng
Schlagworte:	Arteriosclerosis - genetics Arteriosclerosis - metabolism Arteriosclerosis - physiopathology Biological and medical sciences Cardiology. Vascular system Carotid Stenosis - genetics Carotid Stenosis - metabolism Carotid Stenosis - physiopathology Circulatory system Cohort Studies Coronary heart disease Cyclooxygenase 2 Epoprostenol - metabolism Female General aspects Genes Genetics Genotype Health risk assessment Heart Heart attacks Humans Isoenzymes - genetics Isoenzymes - metabolism Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Medical sciences Membrane Proteins Middle Aged Myocardial Infarction - epidemiology Myocardial Infarction - genetics Myocarditis. Cardiomyopathies Neurology Phenotype Polymorphism Polymorphism, Genetic Prospective Studies Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - metabolism Risk Factors Stroke Stroke - epidemiology Stroke - genetics Vascular diseases and vascular malformations of the nervous system
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