Single cell laser dissection with molecular beacon polymerase chain reaction identifies 2A as the predominant serotonin receptor subtype in hypoglossal motoneurons

We hypothesize that sleep state-dependent withdrawal of serotonin (5-hydroxytryptamine, 5-HT) at upper airway (UAW) dilator motoneurons contributes significantly to sleep-related suppression of dilator muscle activity in obstructive sleep apnea. Identification of 5-HT receptor subtypes involved in p...

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Veröffentlicht in:	Neuroscience 2002-01, Vol.113 (1), p.145-154
Hauptverfasser:	Zhan, G, Shaheen, F, Mackiewicz, M, Fenik, P, Veasey, S.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences digoxigenin-labeled and in situ hybridization DNA Primers Fundamental and applied biological sciences. Psychology Hypoglossal Nerve - chemistry In Situ Hybridization laser capture microdissection Lasers Male Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration motor neurons Motor Neurons - chemistry Polymerase Chain Reaction Rats Rats, Sprague-Dawley real-time PCR Receptor, Serotonin, 5-HT2A Receptor, Serotonin, 5-HT2C Receptors, Serotonin - analysis Receptors, Serotonin - genetics Respiration RNA, Messenger - analysis single cell Sleep sleep apnea Sleep Apnea Syndromes taqman upper airway Vertebrates: nervous system and sense organs
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