Effects of copper-aspirin complex on platelet-neutrophil interactions
To investigate the effects of copper-aspirin complex on rat thrombosis and the interaction between piatelet sand neutrophils. METHODS: The model of electrically stimulated carotid artery thrombosis in Sprague Dawley rats was used; the effects of copper-aspirin complex on rat platelet-neutrophil adhe...
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| Veröffentlicht in: | Acta pharmacologica Sinica 2004-05, Vol.25 (5), p.576-580 |
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| creator | Shen, Zhi-qiang Chen, Peng Li, Ling Liu, Wei-ping |
| description | To investigate the effects of copper-aspirin complex on rat thrombosis and the interaction between piatelet sand neutrophils. METHODS: The model of electrically stimulated carotid artery thrombosis in Sprague Dawley rats was used; the effects of copper-aspirin complex on rat platelet-neutrophil adhesion and platelet aggregation stimulated by activated neutrophils were observed by rosette assay and Born's method, respectively. RESULTS:Intragastric copper-aspirin complex (5, 7, and 10 mg/kg) doseMependently prolonged the occlusion time; it significantly decreased the rosette number formed between thrombin-activated platelets and neutrophils; the 50 % of inhibitory concentration (ICs0) was (54.6~4.3)/amol/L. Copper-aspirin complex markedly inhibited rat platelet aggregation induced by either cell free supernatant of activated neutrophils or by activated neutrophil suspension.The values of ICs0 were (224.5+16.2) lamol/L and (820.5~21.4) lamol/L, whereas aspirin had no influence.CONCLUSION: Copper-aspirin complex inhibited platelet-neutrophil interactions through a different property from aspirin and resulted in a more potent antithrombotic actvity |
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METHODS: The model of electrically stimulated carotid artery thrombosis in Sprague Dawley rats was used; the effects of copper-aspirin complex on rat platelet-neutrophil adhesion and platelet aggregation stimulated by activated neutrophils were observed by rosette assay and Born's method, respectively. RESULTS:Intragastric copper-aspirin complex (5, 7, and 10 mg/kg) doseMependently prolonged the occlusion time; it significantly decreased the rosette number formed between thrombin-activated platelets and neutrophils; the 50 % of inhibitory concentration (ICs0) was (54.6~4.3)/amol/L. Copper-aspirin complex markedly inhibited rat platelet aggregation induced by either cell free supernatant of activated neutrophils or by activated neutrophil suspension.The values of ICs0 were (224.5+16.2) lamol/L and (820.5~21.4) lamol/L, whereas aspirin had no influence.CONCLUSION: Copper-aspirin complex inhibited platelet-neutrophil interactions through a different property from aspirin and resulted in a more potent antithrombotic actvity</description><identifier>ISSN: 1671-4083</identifier><identifier>EISSN: 1745-7254</identifier><identifier>PMID: 15132821</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Aspirin - pharmacology ; Blood Platelets - physiology ; Carotid Artery Thrombosis - blood ; Cell Adhesion - drug effects ; Copper - pharmacology ; Drug Combinations ; Male ; Neutrophils - physiology ; Platelet Adhesiveness - drug effects ; Platelet Aggregation - drug effects ; Rats ; Rats, Sprague-Dawley ; 嗜中性粒细胞 ; 细胞粘附作用 ; 血小板 ; 血栓症 ; 阿斯匹林</subject><ispartof>Acta pharmacologica Sinica, 2004-05, Vol.25 (5), p.576-580</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/95561A/95561A.jpg</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15132821$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Zhi-qiang</creatorcontrib><creatorcontrib>Chen, Peng</creatorcontrib><creatorcontrib>Li, Ling</creatorcontrib><creatorcontrib>Liu, Wei-ping</creatorcontrib><title>Effects of copper-aspirin complex on platelet-neutrophil interactions</title><title>Acta pharmacologica Sinica</title><addtitle>Acta Pharmacologica Sinica</addtitle><description>To investigate the effects of copper-aspirin complex on rat thrombosis and the interaction between piatelet sand neutrophils. METHODS: The model of electrically stimulated carotid artery thrombosis in Sprague Dawley rats was used; the effects of copper-aspirin complex on rat platelet-neutrophil adhesion and platelet aggregation stimulated by activated neutrophils were observed by rosette assay and Born's method, respectively. RESULTS:Intragastric copper-aspirin complex (5, 7, and 10 mg/kg) doseMependently prolonged the occlusion time; it significantly decreased the rosette number formed between thrombin-activated platelets and neutrophils; the 50 % of inhibitory concentration (ICs0) was (54.6~4.3)/amol/L. Copper-aspirin complex markedly inhibited rat platelet aggregation induced by either cell free supernatant of activated neutrophils or by activated neutrophil suspension.The values of ICs0 were (224.5+16.2) lamol/L and (820.5~21.4) lamol/L, whereas aspirin had no influence.CONCLUSION: Copper-aspirin complex inhibited platelet-neutrophil interactions through a different property from aspirin and resulted in a more potent antithrombotic actvity</description><subject>Animals</subject><subject>Aspirin - pharmacology</subject><subject>Blood Platelets - physiology</subject><subject>Carotid Artery Thrombosis - blood</subject><subject>Cell Adhesion - drug effects</subject><subject>Copper - pharmacology</subject><subject>Drug Combinations</subject><subject>Male</subject><subject>Neutrophils - physiology</subject><subject>Platelet Adhesiveness - drug effects</subject><subject>Platelet Aggregation - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>嗜中性粒细胞</subject><subject>细胞粘附作用</subject><subject>血小板</subject><subject>血栓症</subject><subject>阿斯匹林</subject><issn>1671-4083</issn><issn>1745-7254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1z01LxDAQBuAiiruu_gWpF2-FJmma5ihL_YAFL3ou6XSyG02TbJOC_nsLu55mXniYl7nI1kRUvBCUV5fLXgtSVGXDVtlNjF9lySgj8jpbEU4YbShZZ22rNUKKudc5-BBwKlQMZjJuiWOw-JN7lwerElpMhcM5TT4cjM2NSzgpSMa7eJtdaWUj3p3nJvt8bj-2r8Xu_eVt-7QrgDKWCuwBuapLpFRozkFWkmgAUI0A3rOB1YyAHBhIUWkl-UCIoLUUUAq9SMU22ePpbpj8ccaYutFEQGuVQz_HThBJiSzZAu_PcO5HHLowmVFNv93_4wt4OAE4eLc_GrfvegXf2ljslnZaNRX7A1BQYXc</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Shen, Zhi-qiang</creator><creator>Chen, Peng</creator><creator>Li, Ling</creator><creator>Liu, Wei-ping</creator><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>Effects of copper-aspirin complex on platelet-neutrophil interactions</title><author>Shen, Zhi-qiang ; Chen, Peng ; Li, Ling ; Liu, Wei-ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c233t-ebce5a60e227f55c9491fccca87c5b3d3631c9d3c974fa95d1172697c07f91fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Aspirin - pharmacology</topic><topic>Blood Platelets - physiology</topic><topic>Carotid Artery Thrombosis - blood</topic><topic>Cell Adhesion - drug effects</topic><topic>Copper - pharmacology</topic><topic>Drug Combinations</topic><topic>Male</topic><topic>Neutrophils - physiology</topic><topic>Platelet Adhesiveness - drug effects</topic><topic>Platelet Aggregation - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>嗜中性粒细胞</topic><topic>细胞粘附作用</topic><topic>血小板</topic><topic>血栓症</topic><topic>阿斯匹林</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Zhi-qiang</creatorcontrib><creatorcontrib>Chen, Peng</creatorcontrib><creatorcontrib>Li, Ling</creatorcontrib><creatorcontrib>Liu, Wei-ping</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta pharmacologica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Zhi-qiang</au><au>Chen, Peng</au><au>Li, Ling</au><au>Liu, Wei-ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of copper-aspirin complex on platelet-neutrophil interactions</atitle><jtitle>Acta pharmacologica Sinica</jtitle><addtitle>Acta Pharmacologica Sinica</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>25</volume><issue>5</issue><spage>576</spage><epage>580</epage><pages>576-580</pages><issn>1671-4083</issn><eissn>1745-7254</eissn><abstract>To investigate the effects of copper-aspirin complex on rat thrombosis and the interaction between piatelet sand neutrophils. METHODS: The model of electrically stimulated carotid artery thrombosis in Sprague Dawley rats was used; the effects of copper-aspirin complex on rat platelet-neutrophil adhesion and platelet aggregation stimulated by activated neutrophils were observed by rosette assay and Born's method, respectively. RESULTS:Intragastric copper-aspirin complex (5, 7, and 10 mg/kg) doseMependently prolonged the occlusion time; it significantly decreased the rosette number formed between thrombin-activated platelets and neutrophils; the 50 % of inhibitory concentration (ICs0) was (54.6~4.3)/amol/L. Copper-aspirin complex markedly inhibited rat platelet aggregation induced by either cell free supernatant of activated neutrophils or by activated neutrophil suspension.The values of ICs0 were (224.5+16.2) lamol/L and (820.5~21.4) lamol/L, whereas aspirin had no influence.CONCLUSION: Copper-aspirin complex inhibited platelet-neutrophil interactions through a different property from aspirin and resulted in a more potent antithrombotic actvity</abstract><cop>United States</cop><pmid>15132821</pmid><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Aspirin - pharmacology Blood Platelets - physiology Carotid Artery Thrombosis - blood Cell Adhesion - drug effects Copper - pharmacology Drug Combinations Male Neutrophils - physiology Platelet Adhesiveness - drug effects Platelet Aggregation - drug effects Rats Rats, Sprague-Dawley 嗜中性粒细胞 细胞粘附作用 血小板 血栓症 阿斯匹林 |
| title | Effects of copper-aspirin complex on platelet-neutrophil interactions |
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