Two monoclonal antibodies to D-dimer-specific inhibitors of fibrin polymerization

D-dimer of human fibrin was used as antigen to obtain monoclonal antibodies (mAbs). We have obtained 16 hybridomas producing mAbs of different specificity. Only two of these mAbs inhibited fibrin polymerization. They are of the IgG-class. One mAb (II-4d) inhibited fibrin polymerization to 100% and a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Thrombosis research 2004, Vol.113 (3), p.251-259
Hauptverfasser:	Lugovskoy, E.V, Gritsenko, P.G, Kolesnikova, I.N, Zolotarova, E.N, Chernishov, V.I, Nieuwenhuizen, W, Komisarenko, S.V
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - metabolism Antibody Specificity Associated diseases and complications Biological and medical sciences Biopolymers Blood and lymphatic vessels Blood Coagulation - immunology Cardiology. Vascular system Diabetes. Impaired glucose tolerance Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme-Linked Immunosorbent Assay Epitopes Fibrin Fibrin - antagonists & inhibitors Fibrin - chemistry Fibrin - ultrastructure Fibrin Fibrinogen Degradation Products - immunology Fibrinogen - immunology Humans Hybridomas - immunology Immunoglobulin Fab Fragments - immunology Medical sciences Monoclonal antibodies Oligopeptides - chemistry Polymerization inhibitors Polymerization sites Protein Structure, Tertiary Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!