Translational up-regulation of antifolate drug targets in the human malaria parasite Plasmodium falciparum upon challenge with inhibitors

The thymidylate cycle in Plasmodium falciparum is essential for cell growth and replication, and dihydrofolate reductase (DHFR), a key enzyme in this cycle, is the target of important antimalarial drugs such as pyrimethamine and cycloguanil. Following previous work, where we found no evidence of upr...

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Veröffentlicht in:	Molecular and biochemical parasitology 2004-07, Vol.136 (1), p.63-70
Hauptverfasser:	Nirmalan, Niroshini, Sims, Paul F G, Hyde, John E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Enzyme Inhibitors - pharmacology Fluorouracil - pharmacology Folic Acid Antagonists - pharmacology Plasmodium falciparum - drug effects Plasmodium falciparum - enzymology Protein Biosynthesis Pyrimethamine - pharmacology Tetrahydrofolate Dehydrogenase - metabolism Thymidylate Synthase - antagonists & inhibitors Thymidylate Synthase - metabolism Triazines - pharmacology Up-Regulation
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