Oral Hypoglycemic Sulfonylurea Glimepiride Preserves the Myoprotective Effects of Ischemic Preconditioning

Background. To investigate whether the sulfonylurea glimepiride affects the myoprotective effects of ischemic preconditioning (IPC), isolated rabbit hearts were perfused with Krebs-Henseleit solution. Methods. Eight hearts underwent IPC consisting of two cycles of 5 min global ischemia and reperfusi...

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Veröffentlicht in:	The Journal of surgical research 2002-06, Vol.105 (2), p.181-188
Hauptverfasser:	Horimoto, Hitoshi, Nakai, Yasunari, Mieno, Shigetoshi, Nomura, Yukiya, Nakahara, Kenichi, Sasaki, Shinjiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Biological and medical sciences Coronary Circulation - drug effects General and cellular metabolism. Vitamins Heart - drug effects Heart - physiopathology Hypoglycemic Agents - pharmacology In Vitro Techniques Ischemic Preconditioning, Myocardial Male Medical sciences Myocardial Infarction - pathology Pharmacology. Drug treatments Pressure Rabbits Reaction Time Sulfonylurea Compounds - pharmacology Ventricular Function, Left
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