DNA Aneuploidy and Integration of Human Papillomavirus Type 16 E6/E7 Oncogenes in Intraepithelial Neoplasia and Invasive Squamous Cell Carcinoma of the Cervix Uteri

Purpose: Increasingly deregulated expression of the E6-E7 oncogenes of high-risk human papillomaviruses (HR-HPVs) has been identified as the major transforming factor in the pathogenesis of cervical dysplasia and derived cancers. The expression of these genes in epithelial stem cells first results i...

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Veröffentlicht in:	Clinical cancer research 2004-05, Vol.10 (9), p.3059-3063
Hauptverfasser:	MELSHEIMER, Peter, VINOKUROVA, Svetlana, WENTZENSEN, Nicolas, BASTERT, Gunther, VON KNEBEL DOEBERITZ, Magnus
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aneuploidy Antineoplastic agents Biological and medical sciences Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - virology Cervical Intraepithelial Neoplasia - genetics Cervical Intraepithelial Neoplasia - pathology Cervical Intraepithelial Neoplasia - virology Chromosome Aberrations - statistics & numerical data DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Female Humans Medical sciences Neoplasm Invasiveness Oncogene Proteins, Viral - genetics Papillomaviridae - genetics Papillomavirus E7 Proteins Papillomavirus Infections - genetics Papillomavirus Infections - pathology Papillomavirus Infections - virology Pharmacology. Drug treatments Repressor Proteins - genetics RNA, Viral - genetics RNA, Viral - metabolism Transcription, Genetic Tumors Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - virology Virus Integration - genetics
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