Histone deacetylase inhibitor, FK228, induces apoptosis and suppresses cell proliferation of human glioblastoma cells in vitro and in vivo

We investigated the effects of FK228 on cell proliferation and apoptosis against human glioblastoma (GM) T98G, U251MG, and U87MG cells. Upon exposure to FK228, cell proliferation was inhibited, and apoptosis detected by the cleavage of CPP32 was induced. FK228 increased the expression levels of p21...

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Veröffentlicht in:	Acta neuropathologica 2004-06, Vol.107 (6), p.523-531
Hauptverfasser:	Sawa, Hiroki, Murakami, Hiromi, Kumagai, Masaoki, Nakasato, Matsuyoshi, Yamauchi, Shigeru, Matsuyama, Nozomu, Tamura, Yasuo, Satone, Akira, Ide, Wataru, Hashimoto, Ikuo, Kamada, Hajime
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Apoptosis Apoptosis - physiology Bad protein Bcl-2 protein bcl-2-Associated X Protein bcl-Associated Death Protein Bcl-x protein Brain cancer Bromodeoxyuridine Carrier Proteins - metabolism Caspase 3 Caspases - metabolism Cell Division - drug effects Cell growth Cell Line, Tumor Cell proliferation Cell Transplantation - methods Chromatin Cyclin-Dependent Kinase Inhibitor p21 Cyclins - metabolism Depsipeptides Dose-Response Relationship, Drug Exons - physiology Gelatinase A Glioblastoma Glioblastoma - pathology Glioblastoma cells GTP-binding protein Histone deacetylase Histone Deacetylase Inhibitors Histone H4 Humans Immunoprecipitation In Situ Nick-End Labeling - methods Invasiveness Matrix Metalloproteinase 2 - metabolism Mice Mice, Nude - physiology Peptides, Cyclic - pharmacology Promoter Regions, Genetic - physiology Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 Time Factors
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