Prevalence of non-organ-specific autoantibodies in patients suffering from duodenal ulcer with and without Helicobacter pylori infection
Autoimmunity, a feature of chronic infection by Helicobacter pylori, is first directed against gastric cells but is also associated with extragastric diseases. The aim of the present work was to look for the influence of the infection on induction of non-organ-specific autoantibodies (NOSAs). We com...
Gespeichert in:
| Veröffentlicht in: | Digestive diseases and sciences 2004-03, Vol.49 (3), p.395-398 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 398 |
|---|---|
| container_issue | 3 |
| container_start_page | 395 |
| container_title | Digestive diseases and sciences |
| container_volume | 49 |
| creator | PELLICANO, Rinaldo TOUSCOZ, Giovanni Antonio SMEDILE, Antonina BERRUTTI, Mara SARACCO, Giorgio REPICI, Alessandro PONZETTO, Antonio RIZZETTO, Mario |
| description | Autoimmunity, a feature of chronic infection by Helicobacter pylori, is first directed against gastric cells but is also associated with extragastric diseases. The aim of the present work was to look for the influence of the infection on induction of non-organ-specific autoantibodies (NOSAs). We compared 49 patients (28 males and 21 females; age range, 36-72 years; mean, 61 +/- 4.6 years) suffering from duodenal ulcer and H. pylori infection (Group A) to 38 subjects (20 male, 18 female; age range, 40-78 years; mean, 63 +/- 3.8 years) affected by duodenal ulcer related to the assumption of nonsteroidal antiinflammatory drugs (Group B). H. pylori infection was diagnosed by histology, 13C-urea breath test, and serum IgG antibodies. Autoimmunitary pattern was demonstrated by the presence of NOSAs in serum. Antinuclear (ANA), anti-smooth muscle (SMA), and anti-liver/kidney microsomal-1 (LKM-1) antibodies were present in 5 of 49 (10.2%), 2 of 49 (4%), and 0 Group A patients, respectively. In Group B, ANA was present in 3 of 38 (7.9%), SMA in 3 of 38 (7.9%), and anti-LKM-1 in 0 patients. The difference was not statistically significant. In this population, H. pylori infection is not associated with an increased prevalence of NOSAs. |
| doi_str_mv | 10.1023/B:DDAS.0000020491.78450.82 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71919658</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>614133481</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-82ad35d621378a3a77339dcfe6af607aa6a92ba7473e70479d3ec61d593c65463</originalsourceid><addsrcrecordid>eNpdkd1qFTEQgIMo9lh9BQkFvdvjJtlNsr3rj1qhYKF6HeYkk5qyJ1mTrKVv4GN3T3ug4tzMwHwzw_ARcsTaNWu5-HR6fH5-cr1ud8HbbmBrpbu-XWv-gqxYr0TDe6lfklXL5FIzJg_Im1JuF3xQTL4mB6xnYui0XJG_Vxn_wIjRIk2exhSblG8gNmVCG3ywFOaaINawSS5goSHSCWrAWAsts_eYQ7yhPqctdXNyGGGk82gx07tQf1GI7rFIc6UXOAabNmDr0p3ux5TDss6jrSHFt-SVh7Hgu30-JD-_fP5xdtFcfv_67ezksrFC8dpoDk70TnImlAYBSgkxOOtRgpetApAw8A2oTglUbacGJ9BK5vpBWNl3UhySj097p5x-z1iq2YZicRwhYpqLUWxgg-z1Ah79B96mOS_vFcNZJ4SQPV-g4yfI5lRKRm-mHLaQ7w1rzU6WOTU7WeZZlnmUZfRu-P3-wrzZonse3dtZgA97AIqF0WeINpR_OKm0Vlo8ACYwn-s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>214333652</pqid></control><display><type>article</type><title>Prevalence of non-organ-specific autoantibodies in patients suffering from duodenal ulcer with and without Helicobacter pylori infection</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>PELLICANO, Rinaldo ; TOUSCOZ, Giovanni Antonio ; SMEDILE, Antonina ; BERRUTTI, Mara ; SARACCO, Giorgio ; REPICI, Alessandro ; PONZETTO, Antonio ; RIZZETTO, Mario</creator><creatorcontrib>PELLICANO, Rinaldo ; TOUSCOZ, Giovanni Antonio ; SMEDILE, Antonina ; BERRUTTI, Mara ; SARACCO, Giorgio ; REPICI, Alessandro ; PONZETTO, Antonio ; RIZZETTO, Mario</creatorcontrib><description>Autoimmunity, a feature of chronic infection by Helicobacter pylori, is first directed against gastric cells but is also associated with extragastric diseases. The aim of the present work was to look for the influence of the infection on induction of non-organ-specific autoantibodies (NOSAs). We compared 49 patients (28 males and 21 females; age range, 36-72 years; mean, 61 +/- 4.6 years) suffering from duodenal ulcer and H. pylori infection (Group A) to 38 subjects (20 male, 18 female; age range, 40-78 years; mean, 63 +/- 3.8 years) affected by duodenal ulcer related to the assumption of nonsteroidal antiinflammatory drugs (Group B). H. pylori infection was diagnosed by histology, 13C-urea breath test, and serum IgG antibodies. Autoimmunitary pattern was demonstrated by the presence of NOSAs in serum. Antinuclear (ANA), anti-smooth muscle (SMA), and anti-liver/kidney microsomal-1 (LKM-1) antibodies were present in 5 of 49 (10.2%), 2 of 49 (4%), and 0 Group A patients, respectively. In Group B, ANA was present in 3 of 38 (7.9%), SMA in 3 of 38 (7.9%), and anti-LKM-1 in 0 patients. The difference was not statistically significant. In this population, H. pylori infection is not associated with an increased prevalence of NOSAs.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1023/B:DDAS.0000020491.78450.82</identifier><identifier>PMID: 15139486</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Aged ; Antibodies, Antinuclear - analysis ; Autoantibodies - analysis ; Autoimmunity ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Duodenal Ulcer - immunology ; Duodenal Ulcer - microbiology ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology. Liver. Pancreas. Abdomen ; Helicobacter Infections - immunology ; Helicobacter pylori ; Human bacterial diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Muscle, Smooth - immunology ; Other diseases. Semiology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Digestive diseases and sciences, 2004-03, Vol.49 (3), p.395-398</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Kluwer Academic Publishers Mar 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-82ad35d621378a3a77339dcfe6af607aa6a92ba7473e70479d3ec61d593c65463</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15678878$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15139486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PELLICANO, Rinaldo</creatorcontrib><creatorcontrib>TOUSCOZ, Giovanni Antonio</creatorcontrib><creatorcontrib>SMEDILE, Antonina</creatorcontrib><creatorcontrib>BERRUTTI, Mara</creatorcontrib><creatorcontrib>SARACCO, Giorgio</creatorcontrib><creatorcontrib>REPICI, Alessandro</creatorcontrib><creatorcontrib>PONZETTO, Antonio</creatorcontrib><creatorcontrib>RIZZETTO, Mario</creatorcontrib><title>Prevalence of non-organ-specific autoantibodies in patients suffering from duodenal ulcer with and without Helicobacter pylori infection</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>Autoimmunity, a feature of chronic infection by Helicobacter pylori, is first directed against gastric cells but is also associated with extragastric diseases. The aim of the present work was to look for the influence of the infection on induction of non-organ-specific autoantibodies (NOSAs). We compared 49 patients (28 males and 21 females; age range, 36-72 years; mean, 61 +/- 4.6 years) suffering from duodenal ulcer and H. pylori infection (Group A) to 38 subjects (20 male, 18 female; age range, 40-78 years; mean, 63 +/- 3.8 years) affected by duodenal ulcer related to the assumption of nonsteroidal antiinflammatory drugs (Group B). H. pylori infection was diagnosed by histology, 13C-urea breath test, and serum IgG antibodies. Autoimmunitary pattern was demonstrated by the presence of NOSAs in serum. Antinuclear (ANA), anti-smooth muscle (SMA), and anti-liver/kidney microsomal-1 (LKM-1) antibodies were present in 5 of 49 (10.2%), 2 of 49 (4%), and 0 Group A patients, respectively. In Group B, ANA was present in 3 of 38 (7.9%), SMA in 3 of 38 (7.9%), and anti-LKM-1 in 0 patients. The difference was not statistically significant. In this population, H. pylori infection is not associated with an increased prevalence of NOSAs.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Antinuclear - analysis</subject><subject>Autoantibodies - analysis</subject><subject>Autoimmunity</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Duodenal Ulcer - immunology</subject><subject>Duodenal Ulcer - microbiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Helicobacter Infections - immunology</subject><subject>Helicobacter pylori</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Muscle, Smooth - immunology</subject><subject>Other diseases. Semiology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkd1qFTEQgIMo9lh9BQkFvdvjJtlNsr3rj1qhYKF6HeYkk5qyJ1mTrKVv4GN3T3ug4tzMwHwzw_ARcsTaNWu5-HR6fH5-cr1ud8HbbmBrpbu-XWv-gqxYr0TDe6lfklXL5FIzJg_Im1JuF3xQTL4mB6xnYui0XJG_Vxn_wIjRIk2exhSblG8gNmVCG3ywFOaaINawSS5goSHSCWrAWAsts_eYQ7yhPqctdXNyGGGk82gx07tQf1GI7rFIc6UXOAabNmDr0p3ux5TDss6jrSHFt-SVh7Hgu30-JD-_fP5xdtFcfv_67ezksrFC8dpoDk70TnImlAYBSgkxOOtRgpetApAw8A2oTglUbacGJ9BK5vpBWNl3UhySj097p5x-z1iq2YZicRwhYpqLUWxgg-z1Ah79B96mOS_vFcNZJ4SQPV-g4yfI5lRKRm-mHLaQ7w1rzU6WOTU7WeZZlnmUZfRu-P3-wrzZonse3dtZgA97AIqF0WeINpR_OKm0Vlo8ACYwn-s</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>PELLICANO, Rinaldo</creator><creator>TOUSCOZ, Giovanni Antonio</creator><creator>SMEDILE, Antonina</creator><creator>BERRUTTI, Mara</creator><creator>SARACCO, Giorgio</creator><creator>REPICI, Alessandro</creator><creator>PONZETTO, Antonio</creator><creator>RIZZETTO, Mario</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>Prevalence of non-organ-specific autoantibodies in patients suffering from duodenal ulcer with and without Helicobacter pylori infection</title><author>PELLICANO, Rinaldo ; TOUSCOZ, Giovanni Antonio ; SMEDILE, Antonina ; BERRUTTI, Mara ; SARACCO, Giorgio ; REPICI, Alessandro ; PONZETTO, Antonio ; RIZZETTO, Mario</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-82ad35d621378a3a77339dcfe6af607aa6a92ba7473e70479d3ec61d593c65463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Antinuclear - analysis</topic><topic>Autoantibodies - analysis</topic><topic>Autoimmunity</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Biological and medical sciences</topic><topic>Duodenal Ulcer - immunology</topic><topic>Duodenal Ulcer - microbiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Helicobacter Infections - immunology</topic><topic>Helicobacter pylori</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Muscle, Smooth - immunology</topic><topic>Other diseases. Semiology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PELLICANO, Rinaldo</creatorcontrib><creatorcontrib>TOUSCOZ, Giovanni Antonio</creatorcontrib><creatorcontrib>SMEDILE, Antonina</creatorcontrib><creatorcontrib>BERRUTTI, Mara</creatorcontrib><creatorcontrib>SARACCO, Giorgio</creatorcontrib><creatorcontrib>REPICI, Alessandro</creatorcontrib><creatorcontrib>PONZETTO, Antonio</creatorcontrib><creatorcontrib>RIZZETTO, Mario</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PELLICANO, Rinaldo</au><au>TOUSCOZ, Giovanni Antonio</au><au>SMEDILE, Antonina</au><au>BERRUTTI, Mara</au><au>SARACCO, Giorgio</au><au>REPICI, Alessandro</au><au>PONZETTO, Antonio</au><au>RIZZETTO, Mario</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of non-organ-specific autoantibodies in patients suffering from duodenal ulcer with and without Helicobacter pylori infection</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>49</volume><issue>3</issue><spage>395</spage><epage>398</epage><pages>395-398</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Autoimmunity, a feature of chronic infection by Helicobacter pylori, is first directed against gastric cells but is also associated with extragastric diseases. The aim of the present work was to look for the influence of the infection on induction of non-organ-specific autoantibodies (NOSAs). We compared 49 patients (28 males and 21 females; age range, 36-72 years; mean, 61 +/- 4.6 years) suffering from duodenal ulcer and H. pylori infection (Group A) to 38 subjects (20 male, 18 female; age range, 40-78 years; mean, 63 +/- 3.8 years) affected by duodenal ulcer related to the assumption of nonsteroidal antiinflammatory drugs (Group B). H. pylori infection was diagnosed by histology, 13C-urea breath test, and serum IgG antibodies. Autoimmunitary pattern was demonstrated by the presence of NOSAs in serum. Antinuclear (ANA), anti-smooth muscle (SMA), and anti-liver/kidney microsomal-1 (LKM-1) antibodies were present in 5 of 49 (10.2%), 2 of 49 (4%), and 0 Group A patients, respectively. In Group B, ANA was present in 3 of 38 (7.9%), SMA in 3 of 38 (7.9%), and anti-LKM-1 in 0 patients. The difference was not statistically significant. In this population, H. pylori infection is not associated with an increased prevalence of NOSAs.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>15139486</pmid><doi>10.1023/B:DDAS.0000020491.78450.82</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2004-03, Vol.49 (3), p.395-398 |
| issn | 0163-2116 1573-2568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71919658 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Antibodies, Antinuclear - analysis Autoantibodies - analysis Autoimmunity Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Duodenal Ulcer - immunology Duodenal Ulcer - microbiology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Helicobacter Infections - immunology Helicobacter pylori Human bacterial diseases Humans Infectious diseases Male Medical sciences Metabolic diseases Middle Aged Muscle, Smooth - immunology Other diseases. Semiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Prevalence of non-organ-specific autoantibodies in patients suffering from duodenal ulcer with and without Helicobacter pylori infection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T17%3A06%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20of%20non-organ-specific%20autoantibodies%20in%20patients%20suffering%20from%20duodenal%20ulcer%20with%20and%20without%20Helicobacter%20pylori%20infection&rft.jtitle=Digestive%20diseases%20and%20sciences&rft.au=PELLICANO,%20Rinaldo&rft.date=2004-03-01&rft.volume=49&rft.issue=3&rft.spage=395&rft.epage=398&rft.pages=395-398&rft.issn=0163-2116&rft.eissn=1573-2568&rft.coden=DDSCDJ&rft_id=info:doi/10.1023/B:DDAS.0000020491.78450.82&rft_dat=%3Cproquest_cross%3E614133481%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=214333652&rft_id=info:pmid/15139486&rfr_iscdi=true |