Determination of some local anesthetics in human serum by gas chromatography with solid-phase extraction
A method of analysis based on solid-phase extraction coupled with capillary gas chromatographic system for determination of mepivacaine, bupivacaine and lidocaine from human serum was developed. As extraction sorbents were used Chromosorb 103, Tenax-GC and Chromosorb T. The best extraction sorbent p...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2004-05, Vol.35 (3), p.593-598 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Baniceru, M Croitoru, O Popescu, S.M |
| description | A method of analysis based on solid-phase extraction coupled with capillary gas chromatographic system for determination of mepivacaine, bupivacaine and lidocaine from human serum was developed. As extraction sorbents were used Chromosorb 103, Tenax-GC and Chromosorb T. The best extraction sorbent proved to be Chromosorb 103. Their recoveries ranged from 91 to 94% at the target concentrations of approx. 1.5
μg
ml
−1 in serum. Relative standard deviation of the recoveries ranged from 3.11 to 5.30 at these concentrations. As internal standard was used lidocaine. The chromatographic analysis was performed on a gas chromatograph equipped with a capillary column, HP-Innowax, and flame ionisation detector. Samples were injected in splitless mode. This method was applied in a stomatological clinic to healthy volunteers to whom superior–posterior alveolar nerve block anesthesia with mepivacaine was administered. |
| doi_str_mv | 10.1016/j.jpba.2004.02.012 |
| format | Article |
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μg
ml
−1 in serum. Relative standard deviation of the recoveries ranged from 3.11 to 5.30 at these concentrations. As internal standard was used lidocaine. The chromatographic analysis was performed on a gas chromatograph equipped with a capillary column, HP-Innowax, and flame ionisation detector. Samples were injected in splitless mode. This method was applied in a stomatological clinic to healthy volunteers to whom superior–posterior alveolar nerve block anesthesia with mepivacaine was administered.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/j.jpba.2004.02.012</identifier><identifier>PMID: 15137984</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Aged ; Analysis ; Analytical, structural and metabolic biochemistry ; Anesthetics, Local - blood ; Biological and medical sciences ; Bupivacaine ; Chromatography, Gas - methods ; Female ; Fundamental and applied biological sciences. Psychology ; Gas chromatography ; General pharmacology ; Human serum ; Humans ; Lidocaine ; Medical sciences ; Mepivacaine ; Middle Aged ; Pharmacology. Drug treatments ; Ropivacaine ; Sensitivity and Specificity ; Solid-phase extraction ; Technology, Pharmaceutical - methods</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2004-05, Vol.35 (3), p.593-598</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-4b82bd2a8883c029300ccc6cb987bc9f78b9b53958bb2f70c7697a3cea63c3283</citedby><cites>FETCH-LOGICAL-c382t-4b82bd2a8883c029300ccc6cb987bc9f78b9b53958bb2f70c7697a3cea63c3283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpba.2004.02.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15744240$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15137984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baniceru, M</creatorcontrib><creatorcontrib>Croitoru, O</creatorcontrib><creatorcontrib>Popescu, S.M</creatorcontrib><title>Determination of some local anesthetics in human serum by gas chromatography with solid-phase extraction</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>A method of analysis based on solid-phase extraction coupled with capillary gas chromatographic system for determination of mepivacaine, bupivacaine and lidocaine from human serum was developed. As extraction sorbents were used Chromosorb 103, Tenax-GC and Chromosorb T. The best extraction sorbent proved to be Chromosorb 103. Their recoveries ranged from 91 to 94% at the target concentrations of approx. 1.5
μg
ml
−1 in serum. Relative standard deviation of the recoveries ranged from 3.11 to 5.30 at these concentrations. As internal standard was used lidocaine. The chromatographic analysis was performed on a gas chromatograph equipped with a capillary column, HP-Innowax, and flame ionisation detector. Samples were injected in splitless mode. This method was applied in a stomatological clinic to healthy volunteers to whom superior–posterior alveolar nerve block anesthesia with mepivacaine was administered.</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Anesthetics, Local - blood</subject><subject>Biological and medical sciences</subject><subject>Bupivacaine</subject><subject>Chromatography, Gas - methods</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gas chromatography</subject><subject>General pharmacology</subject><subject>Human serum</subject><subject>Humans</subject><subject>Lidocaine</subject><subject>Medical sciences</subject><subject>Mepivacaine</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Ropivacaine</subject><subject>Sensitivity and Specificity</subject><subject>Solid-phase extraction</subject><subject>Technology, Pharmaceutical - methods</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAURS0EokPhD7BA3sAuwR9JbEtsUIFSqRKbIrGz7Ben8SiJg-1Q5t_XoxmJrli9zblX9x2E3lJSU0K7j_t6v1pTM0KamrCaUPYM7agUvGJd8-s52hHBaSWIbC_Qq5T2hJCWquYluqAt5ULJZofGLy67OPvFZB8WHAacwuzwFMBM2Cwu5dFlDwn7BY_bbBacXNxmbA_43iQMYwyzyeE-mnU84Aefx1Iw-b5aR5Mcdn9zNHCsfo1eDGZK7s35XqKf377eXX2vbn9c31x9vq2AS5arxkpme2aklBwIU5wQAOjAKiksqEFIq2zLVSutZYMgIDolDAdnOg6cSX6JPpx61xh-b2W_nn0CN03lmbAlLaiiqqNtAdkJhBhSim7Qa_SziQdNiT761Xt99KuPfjVhuvgtoXfn9s3Orv8XOQstwPszYFJROESzgE9PONE0rCGF-3TiXHHxx7uoE3i3gOt9dJB1H_z_djwCzuyarA</recordid><startdate>20040528</startdate><enddate>20040528</enddate><creator>Baniceru, M</creator><creator>Croitoru, O</creator><creator>Popescu, S.M</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040528</creationdate><title>Determination of some local anesthetics in human serum by gas chromatography with solid-phase extraction</title><author>Baniceru, M ; Croitoru, O ; Popescu, S.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-4b82bd2a8883c029300ccc6cb987bc9f78b9b53958bb2f70c7697a3cea63c3283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Anesthetics, Local - blood</topic><topic>Biological and medical sciences</topic><topic>Bupivacaine</topic><topic>Chromatography, Gas - methods</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gas chromatography</topic><topic>General pharmacology</topic><topic>Human serum</topic><topic>Humans</topic><topic>Lidocaine</topic><topic>Medical sciences</topic><topic>Mepivacaine</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Ropivacaine</topic><topic>Sensitivity and Specificity</topic><topic>Solid-phase extraction</topic><topic>Technology, Pharmaceutical - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baniceru, M</creatorcontrib><creatorcontrib>Croitoru, O</creatorcontrib><creatorcontrib>Popescu, S.M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baniceru, M</au><au>Croitoru, O</au><au>Popescu, S.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of some local anesthetics in human serum by gas chromatography with solid-phase extraction</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2004-05-28</date><risdate>2004</risdate><volume>35</volume><issue>3</issue><spage>593</spage><epage>598</epage><pages>593-598</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>A method of analysis based on solid-phase extraction coupled with capillary gas chromatographic system for determination of mepivacaine, bupivacaine and lidocaine from human serum was developed. As extraction sorbents were used Chromosorb 103, Tenax-GC and Chromosorb T. The best extraction sorbent proved to be Chromosorb 103. Their recoveries ranged from 91 to 94% at the target concentrations of approx. 1.5
μg
ml
−1 in serum. Relative standard deviation of the recoveries ranged from 3.11 to 5.30 at these concentrations. As internal standard was used lidocaine. The chromatographic analysis was performed on a gas chromatograph equipped with a capillary column, HP-Innowax, and flame ionisation detector. Samples were injected in splitless mode. This method was applied in a stomatological clinic to healthy volunteers to whom superior–posterior alveolar nerve block anesthesia with mepivacaine was administered.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15137984</pmid><doi>10.1016/j.jpba.2004.02.012</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Analysis Analytical, structural and metabolic biochemistry Anesthetics, Local - blood Biological and medical sciences Bupivacaine Chromatography, Gas - methods Female Fundamental and applied biological sciences. Psychology Gas chromatography General pharmacology Human serum Humans Lidocaine Medical sciences Mepivacaine Middle Aged Pharmacology. Drug treatments Ropivacaine Sensitivity and Specificity Solid-phase extraction Technology, Pharmaceutical - methods |
| title | Determination of some local anesthetics in human serum by gas chromatography with solid-phase extraction |
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