Population pharmacokinetic modeling of a subcutaneous depot for GnRH antagonist degarelix

The objective of this study is to develop a population pharmacokinetic (PK) model that describes the subcutaneous (SC) depot formation of gonadotropin-releasing hormone (GnRH) antagonist degarelix, which is being developed for treatment of prostate cancer, exhibiting dose-volume and dose-concentrati...

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Veröffentlicht in:	Pharmaceutical research 2004-04, Vol.21 (4), p.574-584
Hauptverfasser:	Tornøe, Christoffer W, Agersø, Henrik, Nielsen, Henrik A, Madsen, Henrik, Jonsson, E Niclas
Format:	Artikel
Sprache:	eng
Schlagworte:	Delayed-Action Preparations Dose-Response Relationship, Drug Gonadotropin-Releasing Hormone - antagonists & inhibitors Gonadotropin-Releasing Hormone - metabolism Humans Injections, Subcutaneous Male Models, Biological Oligopeptides - administration & dosage Oligopeptides - pharmacokinetics
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