Gastrin regulates the heparin-binding epidermal-like growth factor promoter via a PKC/EGFR-dependent mechanism

Gastrin is a known growth/differentiation factor for the gastric mucosa. Its effects are likely mediated by the induction of heparin-binding epidermal-like growth factor (HB-EGF), a member of the EGF family of growth factors that is expressed by gastric parietal cells. In this study, we investigated...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2004-06, Vol.286 (6), p.G992-G999
Hauptverfasser:	Sinclair, Natalie F, Ai, Wandong, Raychowdhury, Raktima, Bi, Meixia, Wang, Timothy C, Koh, Theodore J, McLaughlin, John T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cell Nucleus - metabolism Epidermal Growth Factor - genetics Epidermal Growth Factor - metabolism Gastrins - genetics Gastrins - pharmacology Gastrins - physiology Heparin-binding EGF-like Growth Factor Humans Intercellular Signaling Peptides and Proteins Mice Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - genetics Promoter Regions, Genetic - physiology Protein Kinase C - physiology Receptor, Epidermal Growth Factor - physiology Response Elements - genetics Response Elements - physiology Signal Transduction Sp1 Transcription Factor - physiology Stereoisomerism Transcription Factors - metabolism Ultraviolet Rays Zinc - metabolism
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