Effect of single oral administration of YM598, a novel selective endothelin ETA receptor antagonist, on blood pressure in normotensive and hypertensive rats

We investigated the effect of YM598, a selective endothelin ETA receptor antagonist, on blood pressure (BP) in normotensive rats (NTR), spontaneously hypertensive rats (SHR) and Dahl salt-sensitive hypertensive rats (Dahl-SS). We also examined the concomitant effect of YM598 with the L-type Ca2+ cha...

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Veröffentlicht in:	Vascular pharmacology 2004-02, Vol.41 (1), p.27-34
Hauptverfasser:	Yuyama, Hironori, Sonoda, Rie, Shibasaki, Kumiko, Fujimori, Akira, Sudoh, Katsumi, Sasamata, Masao, Miyata, Keiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Blood Pressure - drug effects Blood Pressure - physiology Drug Administration Schedule Endothelin A Receptor Antagonists Hypertension - drug therapy Hypertension - physiopathology Male Pyrimidines - administration & dosage Rats Rats, Inbred Dahl Rats, Inbred SHR Rats, Wistar Receptor, Endothelin A - physiology Sulfonamides - administration & dosage
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