Role of IL-10 in regulating proinflammatory cytokine release by Kupffer cells following trauma-hemorrhage

IL-6 and TNF-alpha production by Kupffer cells is markedly stimulated following trauma-hemorrhage (T-H). Because IL-10 is an anti-inflammatory cytokine, the aim of this study was to determine whether IL-10 regulates Kupffer cell proinflammatory cytokine release following T-H. To study this, we subje...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2004-06, Vol.286 (6), p.G942-G946
Hauptverfasser:	Yokoyama, Yukihiro, Kitchens, William C, Toth, Balazs, Schwacha, Martin G, Rue, 3rd, Loring W, Bland, Kirby I, Chaudry, Irshad H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Hemorrhage - etiology Hemorrhage - metabolism In Vitro Techniques Inflammation Mediators - metabolism Interleukin-10 - blood Interleukin-10 - immunology Interleukin-10 - metabolism Interleukin-6 - metabolism Interleukin-6 - pharmacology Kupffer Cells - metabolism Liver - metabolism Male Rats Rats, Sprague-Dawley Recombinant Proteins - pharmacology Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology Wounds, Penetrating - complications
Online-Zugang:	Volltext
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