A pncA polymorphism to differentiate between Mycobacterium bovis and Mycobacterium tuberculosis

The pyrazinamidase gene coding for the enzyme that activates the bactericidal drug pyrazinamide contains a polymorphic site that is preserved in Mycobacterium bovis. We synthesized two sets of primers, one encompassing a 180 bp fragment, and the second spanning a 726 bp fragment including the full p...

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Veröffentlicht in:	Molecular and cellular probes 2004-06, Vol.18 (3), p.167-170
Hauptverfasser:	Barouni, A.S, Augusto, C.J, Lopes, M.T.P, Zanini, M.S, Salas, C.E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - genetics Base Sequence Diagnosis Humans Mycobacterium bovis Mycobacterium bovis - genetics Mycobacterium bovis - isolation & purification Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification PCR Polymorphism, Restriction Fragment Length Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - microbiology
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