Changes in Cerebral Blood Flow during Cerebrospinal Fluid Pressure Manipulation in Patients with Normal Pressure Hydrocephalus: A Methodological Study
The combination of cerebral blood flow measurement using 15O-water positron emission tomography with magnetic resonance coregistration and CSF infusion studies was used to study the global and regional changes in CBF with changes in CSF pressure in 15 patients with normal pressure hydrocephalus. Wit...
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| Veröffentlicht in: | Journal of cerebral blood flow and metabolism 2004-05, Vol.24 (5), p.579-587 |
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| container_title | Journal of cerebral blood flow and metabolism |
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| creator | Owler, Brian K. Pena, Alonso Momjian, Shahan Czosnyka, Zofia Czosnyka, Marek Harris, Neil G. Smielewski, Piotr Fryer, Tim Donvan, Tim Carpenter, Adrian Pickard, John D. |
| description | The combination of cerebral blood flow measurement using 15O-water positron emission tomography with magnetic resonance coregistration and CSF infusion studies was used to study the global and regional changes in CBF with changes in CSF pressure in 15 patients with normal pressure hydrocephalus. With increases in CSF pressure, there was a variable increase in arterial blood pressure between individuals and global CBF was reduced, including in the cerebellum. Regionally, mean CBF decreased in the thalamus and basal ganglia, as well as in white matter regions. These reductions in CBF were significantly correlated with changes in the CSF pressure and with proximity to the ventricles. A three-dimensional finite-element analysis was used to analyze the effects on ventricular size and the distribution of stress during infusion. To study regional cerebral autoregulation in patients with possible normal pressure hydrocephalus, a sensitive CBF technique is required that provides absolute, not relative normalized, values for regional CBF and an adequate change in cerebral perfusion pressure must be provoked. |
| doi_str_mv | 10.1097/00004647-200405000-00012 |
| format | Article |
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With increases in CSF pressure, there was a variable increase in arterial blood pressure between individuals and global CBF was reduced, including in the cerebellum. Regionally, mean CBF decreased in the thalamus and basal ganglia, as well as in white matter regions. These reductions in CBF were significantly correlated with changes in the CSF pressure and with proximity to the ventricles. A three-dimensional finite-element analysis was used to analyze the effects on ventricular size and the distribution of stress during infusion. To study regional cerebral autoregulation in patients with possible normal pressure hydrocephalus, a sensitive CBF technique is required that provides absolute, not relative normalized, values for regional CBF and an adequate change in cerebral perfusion pressure must be provoked.</description><identifier>ISSN: 0271-678X</identifier><identifier>EISSN: 1559-7016</identifier><identifier>DOI: 10.1097/00004647-200405000-00012</identifier><identifier>PMID: 15129190</identifier><identifier>CODEN: JCBMDN</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Biological and medical sciences ; Cerebrospinal Fluid Pressure ; Cerebrovascular Circulation - physiology ; Female ; Hemodynamics ; Humans ; Hydrocephalus, Normal Pressure - cerebrospinal fluid ; Hydrocephalus, Normal Pressure - metabolism ; Magnetic Resonance Imaging - instrumentation ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Middle Aged ; Neurology ; Regional Blood Flow ; Statistics as Topic ; Tomography, Emission-Computed - instrumentation ; Tomography, Emission-Computed - methods ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Journal of cerebral blood flow and metabolism, 2004-05, Vol.24 (5), p.579-587</ispartof><rights>2004 The International Society for Cerebral Blood Flow and Metabolism</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Nature Publishing Group May 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-2e402041ca39c2ea88d24c9cc6805836e91a1e1bf710d0374179ec6c7577f1ff3</citedby><cites>FETCH-LOGICAL-c464t-2e402041ca39c2ea88d24c9cc6805836e91a1e1bf710d0374179ec6c7577f1ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1097/00004647-200405000-00012$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1097/00004647-200405000-00012$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,777,781,21800,27905,27906,43602,43603</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15753526$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15129190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Owler, Brian K.</creatorcontrib><creatorcontrib>Pena, Alonso</creatorcontrib><creatorcontrib>Momjian, Shahan</creatorcontrib><creatorcontrib>Czosnyka, Zofia</creatorcontrib><creatorcontrib>Czosnyka, Marek</creatorcontrib><creatorcontrib>Harris, Neil G.</creatorcontrib><creatorcontrib>Smielewski, Piotr</creatorcontrib><creatorcontrib>Fryer, Tim</creatorcontrib><creatorcontrib>Donvan, Tim</creatorcontrib><creatorcontrib>Carpenter, Adrian</creatorcontrib><creatorcontrib>Pickard, John D.</creatorcontrib><title>Changes in Cerebral Blood Flow during Cerebrospinal Fluid Pressure Manipulation in Patients with Normal Pressure Hydrocephalus: A Methodological Study</title><title>Journal of cerebral blood flow and metabolism</title><addtitle>J Cereb Blood Flow Metab</addtitle><description>The combination of cerebral blood flow measurement using 15O-water positron emission tomography with magnetic resonance coregistration and CSF infusion studies was used to study the global and regional changes in CBF with changes in CSF pressure in 15 patients with normal pressure hydrocephalus. 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To study regional cerebral autoregulation in patients with possible normal pressure hydrocephalus, a sensitive CBF technique is required that provides absolute, not relative normalized, values for regional CBF and an adequate change in cerebral perfusion pressure must be provoked.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cerebrospinal Fluid Pressure</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Female</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Hydrocephalus, Normal Pressure - cerebrospinal fluid</subject><subject>Hydrocephalus, Normal Pressure - metabolism</subject><subject>Magnetic Resonance Imaging - instrumentation</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Regional Blood Flow</subject><subject>Statistics as Topic</subject><subject>Tomography, Emission-Computed - 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Academic</collection><jtitle>Journal of cerebral blood flow and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Owler, Brian K.</au><au>Pena, Alonso</au><au>Momjian, Shahan</au><au>Czosnyka, Zofia</au><au>Czosnyka, Marek</au><au>Harris, Neil G.</au><au>Smielewski, Piotr</au><au>Fryer, Tim</au><au>Donvan, Tim</au><au>Carpenter, Adrian</au><au>Pickard, John D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in Cerebral Blood Flow during Cerebrospinal Fluid Pressure Manipulation in Patients with Normal Pressure Hydrocephalus: A Methodological Study</atitle><jtitle>Journal of cerebral blood flow and metabolism</jtitle><addtitle>J Cereb Blood Flow Metab</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>24</volume><issue>5</issue><spage>579</spage><epage>587</epage><pages>579-587</pages><issn>0271-678X</issn><eissn>1559-7016</eissn><coden>JCBMDN</coden><abstract>The combination of cerebral blood flow measurement using 15O-water positron emission tomography with magnetic resonance coregistration and CSF infusion studies was used to study the global and regional changes in CBF with changes in CSF pressure in 15 patients with normal pressure hydrocephalus. With increases in CSF pressure, there was a variable increase in arterial blood pressure between individuals and global CBF was reduced, including in the cerebellum. Regionally, mean CBF decreased in the thalamus and basal ganglia, as well as in white matter regions. These reductions in CBF were significantly correlated with changes in the CSF pressure and with proximity to the ventricles. A three-dimensional finite-element analysis was used to analyze the effects on ventricular size and the distribution of stress during infusion. 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| identifier | ISSN: 0271-678X |
| ispartof | Journal of cerebral blood flow and metabolism, 2004-05, Vol.24 (5), p.579-587 |
| issn | 0271-678X 1559-7016 |
| language | eng |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Aged Biological and medical sciences Cerebrospinal Fluid Pressure Cerebrovascular Circulation - physiology Female Hemodynamics Humans Hydrocephalus, Normal Pressure - cerebrospinal fluid Hydrocephalus, Normal Pressure - metabolism Magnetic Resonance Imaging - instrumentation Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Neurology Regional Blood Flow Statistics as Topic Tomography, Emission-Computed - instrumentation Tomography, Emission-Computed - methods Vascular diseases and vascular malformations of the nervous system |
| title | Changes in Cerebral Blood Flow during Cerebrospinal Fluid Pressure Manipulation in Patients with Normal Pressure Hydrocephalus: A Methodological Study |
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