The myosin binding protein is a novel mineralocorticoid receptor binding partner

The mineralocorticoid receptor (MR) plays a role in congestive heart failure; however, the molecular mechanism(s) remains undefined. We hypothesized that interaction of the MR with a cardiac protein modulates the transcriptional activation function of the MR within the heart. We used the yeast two-h...

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Veröffentlicht in:	Molecular and cellular endocrinology 2004-03, Vol.217 (1), p.221-227
Hauptverfasser:	Bratton, Melyssa R, Gomez-Sanchez, Elise P, Gomez-Sanchez, Celso E, Subauste, Jose S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone - pharmacology Carrier Proteins - genetics Carrier Proteins - metabolism Cloning, Molecular DNA, Complementary - genetics Gene Library Glucocorticoid receptor Humans Mineralocorticoid receptor Myocardium - metabolism Myosin binding protein-c (cardiac) Protein Binding - drug effects Protein Binding - genetics Protein Structure, Tertiary - drug effects Protein Structure, Tertiary - genetics Receptors, Mineralocorticoid - genetics Receptors, Mineralocorticoid - metabolism Two-Hybrid System Techniques Yeasts
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