Effects of selenium on altered mechanical and electrical cardiac activities of diabetic rat
Since selenium compounds can restore some metabolic parameters and structural alterations of diabetic rat heart, we were tempted to investigate whether these beneficial effects extend to the diabetic rat cardiac dysfunctions. Diabetes was induced by streptozotocin (50 mg/kg body weight) and rats wer...
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| Veröffentlicht in: | Archives of biochemistry and biophysics 2004-06, Vol.426 (1), p.83-90 |
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| creator | Ayaz, Murat Ozdemir, Semir Ugur, Mehmet Vassort, Guy Turan, Belma |
| description | Since selenium compounds can restore some metabolic parameters and structural alterations of diabetic rat heart, we were tempted to investigate whether these beneficial effects extend to the diabetic rat cardiac dysfunctions. Diabetes was induced by streptozotocin (50
mg/kg body weight) and rats were then treated with sodium selenite (5
μmol/kg body weight/day) for four weeks. Electrically stimulated isometric contraction and intracellular action potential in isolated papillary muscle strips and transient (
I
to) and steady state (
I
ss) outward K
+ currents in isolated cardiomyocytes were recorded. Sodium selenite treatment could reverse the prolongation in both action potential duration and twitch duration of the diabetic rats, and also cause significant increases in the diminished amplitudes of the two K
+ currents. Treatment of rats with sodium selenite also markedly increased the depressed acid-soluble sulfhydryl levels of the hearts. Our data suggest that the beneficial effects of sodium selenite treatment on the mechanical and electrical activities of the diabetic rat heart appear to be due to the restoration of the diminished K
+ currents, partially, related to the restoration of the cell glutathione redox cycle. |
| doi_str_mv | 10.1016/j.abb.2004.03.030 |
| format | Article |
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mg/kg body weight) and rats were then treated with sodium selenite (5
μmol/kg body weight/day) for four weeks. Electrically stimulated isometric contraction and intracellular action potential in isolated papillary muscle strips and transient (
I
to) and steady state (
I
ss) outward K
+ currents in isolated cardiomyocytes were recorded. Sodium selenite treatment could reverse the prolongation in both action potential duration and twitch duration of the diabetic rats, and also cause significant increases in the diminished amplitudes of the two K
+ currents. Treatment of rats with sodium selenite also markedly increased the depressed acid-soluble sulfhydryl levels of the hearts. Our data suggest that the beneficial effects of sodium selenite treatment on the mechanical and electrical activities of the diabetic rat heart appear to be due to the restoration of the diminished K
+ currents, partially, related to the restoration of the cell glutathione redox cycle.</description><identifier>ISSN: 0003-9861</identifier><identifier>EISSN: 1096-0384</identifier><identifier>DOI: 10.1016/j.abb.2004.03.030</identifier><identifier>PMID: 15130786</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Action potential ; Action Potentials - drug effects ; Action Potentials - physiology ; Animals ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; Body Weight ; Contraction ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Experimental - physiopathology ; Electric Capacitance ; Electric Stimulation ; Electrophysiology ; Female ; Glutathione metabolism ; Heart - drug effects ; Heart - physiopathology ; Insulin - blood ; K + currents ; Male ; Myocardial Contraction - drug effects ; Myocardial Contraction - physiology ; Myocardium - metabolism ; Myocytes, Cardiac - drug effects ; Myocytes, Cardiac - physiology ; Papillary Muscles - drug effects ; Papillary Muscles - physiology ; Potassium Channels - drug effects ; Potassium Channels - physiology ; Rats ; Rats, Wistar ; Sodium selenite ; Sodium Selenite - pharmacology</subject><ispartof>Archives of biochemistry and biophysics, 2004-06, Vol.426 (1), p.83-90</ispartof><rights>2004 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-1edd9f1aa245ed7d72ec57bb24ab83d87dcd0d6f487a1f268881aa85f917475e3</citedby><cites>FETCH-LOGICAL-c415t-1edd9f1aa245ed7d72ec57bb24ab83d87dcd0d6f487a1f268881aa85f917475e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.abb.2004.03.030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15130786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ayaz, Murat</creatorcontrib><creatorcontrib>Ozdemir, Semir</creatorcontrib><creatorcontrib>Ugur, Mehmet</creatorcontrib><creatorcontrib>Vassort, Guy</creatorcontrib><creatorcontrib>Turan, Belma</creatorcontrib><title>Effects of selenium on altered mechanical and electrical cardiac activities of diabetic rat</title><title>Archives of biochemistry and biophysics</title><addtitle>Arch Biochem Biophys</addtitle><description>Since selenium compounds can restore some metabolic parameters and structural alterations of diabetic rat heart, we were tempted to investigate whether these beneficial effects extend to the diabetic rat cardiac dysfunctions. Diabetes was induced by streptozotocin (50
mg/kg body weight) and rats were then treated with sodium selenite (5
μmol/kg body weight/day) for four weeks. Electrically stimulated isometric contraction and intracellular action potential in isolated papillary muscle strips and transient (
I
to) and steady state (
I
ss) outward K
+ currents in isolated cardiomyocytes were recorded. Sodium selenite treatment could reverse the prolongation in both action potential duration and twitch duration of the diabetic rats, and also cause significant increases in the diminished amplitudes of the two K
+ currents. Treatment of rats with sodium selenite also markedly increased the depressed acid-soluble sulfhydryl levels of the hearts. Our data suggest that the beneficial effects of sodium selenite treatment on the mechanical and electrical activities of the diabetic rat heart appear to be due to the restoration of the diminished K
+ currents, partially, related to the restoration of the cell glutathione redox cycle.</description><subject>Action potential</subject><subject>Action Potentials - drug effects</subject><subject>Action Potentials - physiology</subject><subject>Animals</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Glucose - metabolism</subject><subject>Body Weight</subject><subject>Contraction</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Electric Capacitance</subject><subject>Electric Stimulation</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Glutathione metabolism</subject><subject>Heart - drug effects</subject><subject>Heart - physiopathology</subject><subject>Insulin - blood</subject><subject>K + currents</subject><subject>Male</subject><subject>Myocardial Contraction - drug effects</subject><subject>Myocardial Contraction - physiology</subject><subject>Myocardium - metabolism</subject><subject>Myocytes, Cardiac - drug effects</subject><subject>Myocytes, Cardiac - physiology</subject><subject>Papillary Muscles - drug effects</subject><subject>Papillary Muscles - physiology</subject><subject>Potassium Channels - drug effects</subject><subject>Potassium Channels - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sodium selenite</subject><subject>Sodium Selenite - pharmacology</subject><issn>0003-9861</issn><issn>1096-0384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlKBDEQhoMoOi4P4EVy8tZjVW9J40nEDQQvevIQ0kkFM_SiSUbw7Y3OgDehoKjiqx_qY-wUYYmA7cVqqft-WQLUS6hywQ5bIHRtAZWsd9kCAKqiky0esMMYVwCIdVvuswNssAIh2wV7vXGOTIp8djzSQJNfj3yeuB4SBbJ8JPOmJ2_0wPVkeSZMCr-j0cF6bbg2yX_65Ok3I696St7woNMx23N6iHSy7Ufs5fbm-fq-eHy6e7i-eixMjU0qkKztHGpd1g1ZYUVJphF9X9a6l5WVwhoLtnW1FBpd2UopMywb16GoRUPVETvf5L6H-WNNManRR0PDoCea11EJ7LCBrskgbkAT5hgDOfUe_KjDl0JQP0bVSmWj6seogioX5Juzbfi6H8n-XWwVZuByA1B-8dNTUNF4mgxZH7IsZWf_T_w3cG2HEw</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>Ayaz, Murat</creator><creator>Ozdemir, Semir</creator><creator>Ugur, Mehmet</creator><creator>Vassort, Guy</creator><creator>Turan, Belma</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040601</creationdate><title>Effects of selenium on altered mechanical and electrical cardiac activities of diabetic rat</title><author>Ayaz, Murat ; Ozdemir, Semir ; Ugur, Mehmet ; Vassort, Guy ; Turan, Belma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-1edd9f1aa245ed7d72ec57bb24ab83d87dcd0d6f487a1f268881aa85f917475e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Action potential</topic><topic>Action Potentials - drug effects</topic><topic>Action Potentials - physiology</topic><topic>Animals</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Glucose - metabolism</topic><topic>Body Weight</topic><topic>Contraction</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Electric Capacitance</topic><topic>Electric Stimulation</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Glutathione metabolism</topic><topic>Heart - drug effects</topic><topic>Heart - physiopathology</topic><topic>Insulin - blood</topic><topic>K + currents</topic><topic>Male</topic><topic>Myocardial Contraction - drug effects</topic><topic>Myocardial Contraction - physiology</topic><topic>Myocardium - metabolism</topic><topic>Myocytes, Cardiac - drug effects</topic><topic>Myocytes, Cardiac - physiology</topic><topic>Papillary Muscles - drug effects</topic><topic>Papillary Muscles - physiology</topic><topic>Potassium Channels - drug effects</topic><topic>Potassium Channels - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sodium selenite</topic><topic>Sodium Selenite - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ayaz, Murat</creatorcontrib><creatorcontrib>Ozdemir, Semir</creatorcontrib><creatorcontrib>Ugur, Mehmet</creatorcontrib><creatorcontrib>Vassort, Guy</creatorcontrib><creatorcontrib>Turan, Belma</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ayaz, Murat</au><au>Ozdemir, Semir</au><au>Ugur, Mehmet</au><au>Vassort, Guy</au><au>Turan, Belma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of selenium on altered mechanical and electrical cardiac activities of diabetic rat</atitle><jtitle>Archives of biochemistry and biophysics</jtitle><addtitle>Arch Biochem Biophys</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>426</volume><issue>1</issue><spage>83</spage><epage>90</epage><pages>83-90</pages><issn>0003-9861</issn><eissn>1096-0384</eissn><abstract>Since selenium compounds can restore some metabolic parameters and structural alterations of diabetic rat heart, we were tempted to investigate whether these beneficial effects extend to the diabetic rat cardiac dysfunctions. Diabetes was induced by streptozotocin (50
mg/kg body weight) and rats were then treated with sodium selenite (5
μmol/kg body weight/day) for four weeks. Electrically stimulated isometric contraction and intracellular action potential in isolated papillary muscle strips and transient (
I
to) and steady state (
I
ss) outward K
+ currents in isolated cardiomyocytes were recorded. Sodium selenite treatment could reverse the prolongation in both action potential duration and twitch duration of the diabetic rats, and also cause significant increases in the diminished amplitudes of the two K
+ currents. Treatment of rats with sodium selenite also markedly increased the depressed acid-soluble sulfhydryl levels of the hearts. Our data suggest that the beneficial effects of sodium selenite treatment on the mechanical and electrical activities of the diabetic rat heart appear to be due to the restoration of the diminished K
+ currents, partially, related to the restoration of the cell glutathione redox cycle.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15130786</pmid><doi>10.1016/j.abb.2004.03.030</doi><tpages>8</tpages></addata></record> |
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| subjects | Action potential Action Potentials - drug effects Action Potentials - physiology Animals Blood Glucose - drug effects Blood Glucose - metabolism Body Weight Contraction Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Electric Capacitance Electric Stimulation Electrophysiology Female Glutathione metabolism Heart - drug effects Heart - physiopathology Insulin - blood K + currents Male Myocardial Contraction - drug effects Myocardial Contraction - physiology Myocardium - metabolism Myocytes, Cardiac - drug effects Myocytes, Cardiac - physiology Papillary Muscles - drug effects Papillary Muscles - physiology Potassium Channels - drug effects Potassium Channels - physiology Rats Rats, Wistar Sodium selenite Sodium Selenite - pharmacology |
| title | Effects of selenium on altered mechanical and electrical cardiac activities of diabetic rat |
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