Dissecting the loci of low‐level quinine resistance in malaria parasites

Summary Quinine (QN) remains effective against Plasmodium falciparum, but its decreasing efficacy is documented from different continents. Multiple genes are likely to contribute to the evolution of QN resistance. To locate genes contributing to QN response variation, we have searched a P. falciparu...

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Veröffentlicht in:	Molecular microbiology 2004-05, Vol.52 (4), p.985-997
Hauptverfasser:	Ferdig, Michael T., Cooper, Roland A., Mu, Jianbing, Deng, Bingbing, Joy, Deirdre A., Su, Xin‐zhuan, Wellems, Thomas E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antimalarials - pharmacology ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - physiology Biological and medical sciences Chloroquine - pharmacology Chromosome Mapping Drug Resistance - genetics Fundamental and applied biological sciences. Psychology Genes, Protozoan Human protozoal diseases Infectious diseases Malaria Medical sciences Membrane Proteins - genetics Membrane Proteins - physiology Membrane Transport Proteins Microbiology Molecular Sequence Data Multifactorial Inheritance Parasitic diseases Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Polymorphism, Genetic Protozoal diseases Protozoan Proteins - genetics Protozoan Proteins - physiology Quantitative Trait Loci Quantitative Trait, Heritable Quinine - pharmacology Repetitive Sequences, Nucleic Acid Sodium-Hydrogen Exchangers - genetics Sodium-Hydrogen Exchangers - physiology
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