Angiotensin II Type-1 Receptor Blocker Valsartan Enhances Insulin Sensitivity in Skeletal Muscles of Diabetic Mice

ABSTRACT—Angiotensin II has been shown to contribute to the pathogenesis of insulin resistance; however, the mechanism is not well understood. The present study was undertaken to investigate the potential effect of an angiotensin II type-1 (AT1) receptor blocker, valsartan, to improve insulin resist...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2004-05, Vol.43 (5), p.1003-1010
Hauptverfasser:	Shiuchi, Tetsuya, Iwai, Masaru, Li, Huan-Sheng, Wu, Lan, Min, Li-Juan, Li, Jian-Mei, Okumura, Midori, Cui, Tai-Xing, Horiuchi, Masatsugu
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Type 1 Receptor Blockers Animals Antihypertensive agents Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Glucose - analysis Cardiology. Vascular system Cardiovascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Crosses, Genetic Deoxyglucose - pharmacokinetics Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Disease Models, Animal Energy Intake - drug effects Gene Expression Regulation - drug effects Glucose Transporter Type 4 Imidazoles - pharmacology Insulin - blood Insulin Receptor Substrate Proteins Insulin Resistance Male Medical sciences Mice Mice, Inbred C57BL Mice, Mutant Strains Mice, Obese Monosaccharide Transport Proteins - metabolism Muscle Proteins - metabolism Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Pharmacology. Drug treatments Phosphoproteins - metabolism Phosphorylation - drug effects Protein Processing, Post-Translational - drug effects Protein Transport - drug effects Pyridines - pharmacology Signal Transduction - drug effects Superoxides - metabolism Tetrazoles - pharmacology Tetrazoles - therapeutic use Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics Valine - analogs & derivatives Valine - pharmacology Valine - therapeutic use Valsartan
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